- Facile preparation of aromatic ketones from aromatic bromides and arenes with aldehydes
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Aromatic ketones were efficiently prepared in good yields by the reactions of aryl bromides with n-BuLi, followed by the reactions with aromatic aldehydes or aliphatic aldehydes and the subsequent treatment with molecular iodine and K2CO3, in a one-pot method. The same treatment of arenes, instead of aromatic bromides, also provided the corresponding aromatic ketones in good yields. Using these methods, various diaryl ketones and alkyl aryl ketones bearing electron-rich aromatics and electron-deficient aromatics could be prepared efficiently by a simple, transition-metal-free, and therefore environmentally benign experimental procedure.
- Ushijima, Sousuke,Dohi, Souya,Moriyama, Katsuhiko,Togo, Hideo
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scheme or table
p. 1436 - 1442
(2012/03/09)
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- Synthesis of 2-keto-imidazoles utilizing N -arylamino-substituted N-heterocyclic carbenes
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A new method for the synthesis of 2-aroyl-, 2-heteroaroyl-, and 2-cinnamoyl-substituted imidazoles in very good yields has been developed. The reaction employs novel nitrogen heterocyclic carbenes (NHCs), namely, N-arylamino-substituted NHCs, formed in situ from the corresponding imidazolium salts, and subsequent reaction with aromatic, heteroaromatic, and cinnamic aldehydes without utilizing transition metals or expensive specialized catalysts.(Figure Presented)
- Zarganes-Tzitzikas, Tryfon,Neochoritis, Constantinos G.,Stephanidou-Stephanatou, Julia,Tsoleridis, Constantinos A.
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supporting information; experimental part
p. 1468 - 1471
(2011/04/26)
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