Benzonorbornadiene Derivatives and Reactions Thereof
A bioorthogonal molecule can include a molecule having a structure according the above wherein R1-R8 are independently selected from H, a substituted or unsubstituted C1-C4 alkyl or alkylene group, COOH, COORsu
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Paragraph 0297-0298
(2019/10/17)
Rapid and efficient tetrazine-induced drug release from highly stable benzonorbornadiene derivatives
A novel class of bioorthogonal release reactions based on benzonorbornadiene derivatives was developed. These carrier molecules are highly stable at physiological conditions, but react rapidly with 1,2,4,5-tetrazines, and near-quantitatively release cargo
Xu, Minghao,Tu, Julian,Franzini, Raphael M.
supporting information
p. 6271 - 6274
(2017/07/10)
4-Aryliden-2-methyloxazol-5(4H)-one as a new scaffold for selective reversible MAGL inhibitors
This study reports on a preliminary structure-activity relationship exploration of 4-aryliden-2-methyloxazol-5(4H)-one-based compounds as MAGL/FAAH inhibitors. Our results highlight that this scaffold may serve for the development of selective MAGL inhibi
Synthesis and properties of ring-deactivated deuterated (hydroxymethyl)pyrroles
A sequence, based on a Mitsunobu displacement at the hydroxymethyl position of deuterium-labeled, N-substituted 2-(hydroxymethyl)pyrroles, is reported as a general procedure to determine the ability of the N-substituent to deactivate the heterocycle. An S
Abell, Andrew D.,Nabbs, Brent K.,Battersby, Alan R.
p. 1741 - 1746
(2007/10/03)
Synthesis and Amino Acid Chain Extension of 1-Acylated Hydroxymethylpyrroles
Acylation of pyrrole-2-carbaldehyde (3) with an N-phthaloyl amino acid chloride, N,N-diisopropylethylamine and 4-dimethylaminopyridine (dmap) gave the 1-acylpyrrole-2-carbaldehydes (4a-c).The 1-acylated pyrroles (4d-i), (8) and (9) were similarly prepared
Abell, Andrew D.,Litten, J. Christopher
p. 1473 - 1484
(2007/10/02)
N-Acetylierung substituierter Pyrrole
Using dimethylaminopyridine a method is presented which allows to transform substituted pyrroles into the N-acetates in high yields.
Nickisch, Klaus,Klose, Walter,Bohlmann, Ferdinand
p. 2036 - 2037
(2007/10/02)
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