30186-49-3Relevant academic research and scientific papers
Benzonorbornadiene Derivatives and Reactions Thereof
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Paragraph 0297-0298, (2019/10/17)
A bioorthogonal molecule can include a molecule having a structure according the above wherein R1-R8 are independently selected from H, a substituted or unsubstituted C1-C4 alkyl or alkylene group, COOH, COORsu
Rapid and efficient tetrazine-induced drug release from highly stable benzonorbornadiene derivatives
Xu, Minghao,Tu, Julian,Franzini, Raphael M.
supporting information, p. 6271 - 6274 (2017/07/10)
A novel class of bioorthogonal release reactions based on benzonorbornadiene derivatives was developed. These carrier molecules are highly stable at physiological conditions, but react rapidly with 1,2,4,5-tetrazines, and near-quantitatively release cargo
4-Aryliden-2-methyloxazol-5(4H)-one as a new scaffold for selective reversible MAGL inhibitors
Granchi, Carlotta,Rizzolio, Flavio,Bordoni, Vittorio,Caligiuri, Isabella,Manera, Clementina,Macchia, Marco,Minutolo, Filippo,Martinelli, Adriano,Giordano, Antonio,Tuccinardi, Tiziano
, p. 137 - 146 (2016/01/12)
This study reports on a preliminary structure-activity relationship exploration of 4-aryliden-2-methyloxazol-5(4H)-one-based compounds as MAGL/FAAH inhibitors. Our results highlight that this scaffold may serve for the development of selective MAGL inhibi
Synthesis and properties of ring-deactivated deuterated (hydroxymethyl)pyrroles
Abell, Andrew D.,Nabbs, Brent K.,Battersby, Alan R.
, p. 1741 - 1746 (2007/10/03)
A sequence, based on a Mitsunobu displacement at the hydroxymethyl position of deuterium-labeled, N-substituted 2-(hydroxymethyl)pyrroles, is reported as a general procedure to determine the ability of the N-substituent to deactivate the heterocycle. An S
Synthesis and Amino Acid Chain Extension of 1-Acylated Hydroxymethylpyrroles
Abell, Andrew D.,Litten, J. Christopher
, p. 1473 - 1484 (2007/10/02)
Acylation of pyrrole-2-carbaldehyde (3) with an N-phthaloyl amino acid chloride, N,N-diisopropylethylamine and 4-dimethylaminopyridine (dmap) gave the 1-acylpyrrole-2-carbaldehydes (4a-c).The 1-acylated pyrroles (4d-i), (8) and (9) were similarly prepared
N-Acetylierung substituierter Pyrrole
Nickisch, Klaus,Klose, Walter,Bohlmann, Ferdinand
, p. 2036 - 2037 (2007/10/02)
Using dimethylaminopyridine a method is presented which allows to transform substituted pyrroles into the N-acetates in high yields.
