302355-79-9

Basic information

• Product Name: Morpholine, 4-(3-azetidinyl)- (9CI)
• Synonyms: Morpholine, 4-(3-azetidinyl)- (9CI);4-(3-azetidinyl)morpholine(SALTDATA: 2HCl 0.3H2O);4-(Azetidin-3-yl)morpholine
• CAS NO: 302355-79-9
• Molecular Formula: C₇H₁₄N₂O
• Molecular Weight: 142.19886
• Product Categories: AMINETERTIARY
• Mol File: 302355-79-9.mol

Chemical Properties

• Boiling Point: 227℃
• Flash Point: 91℃
• Appearance: /
• Density: 1.100
• Vapor Pressure: 0.079mmHg at 25°C
• Refractive Index: 1.513
• CAS DataBase Reference: Morpholine, 4-(3-azetidinyl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Morpholine, 4-(3-azetidinyl)- (9CI)(302355-79-9)
• EPA Substance Registry System: Morpholine, 4-(3-azetidinyl)- (9CI)(302355-79-9)

Safety Data

• Hazardous Substances Data: 302355-79-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Morpholine, 4-(3-azetidinyl)(9CI) is used as an intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of new drugs with specific therapeutic properties.
Used in Agricultural Chemicals Industry:
In the agricultural sector, Morpholine, 4-(3-azetidinyl)(9CI) is utilized as a component in the formulation of agricultural chemicals, enhancing the effectiveness of these products in crop protection and management.
Used as a Solvent in Polymer and Resin Manufacturing:
Morpholine, 4-(3-azetidinyl)(9CI) serves as a solvent in the production of polymers and resins, facilitating the manufacturing process and improving the end product's characteristics.
Used as a Corrosion Inhibitor in Oil and Gas Industry:
Morpholine, 4-(3-azetidinyl)(9CI) is employed as a corrosion inhibitor in the oil and gas industry, protecting equipment and infrastructure from the damaging effects of corrosive substances.
Used as a Stabilizer in Rubber and Plastics Production:
Morpholine, 4-(3-azetidinyl)(9CI) is used as a stabilizer in the production of rubber and plastics, ensuring the stability and longevity of these materials under various conditions.
Used in Organic Synthesis:
Morpholine, 4-(3-azetidinyl)(9CI) has potential applications in organic synthesis, acting as a building block for the synthesis of other complex organic compounds, contributing to the advancement of chemical research and development.
It is crucial to handle and utilize Morpholine, 4-(3-azetidinyl)(9CI) with caution due to its potential hazards if not properly managed.

InChI:InChI=1/C7H14N2O/c1-3-10-4-2-9(1)7-5-8-6-7/h7-8H,1-6H2

Upstream product

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Relevant articles and documents

7-(MORPHOLIN-4-YL)PYRAZOLE[1,5-A]PYRIMIDINE DERIVATIVES WHICH ARE USEFUL FOR THE TREATMENT OF IMMUNE OR INFLAMMATORY DISEASES OR CANCER

A compound of the general formula (I) wherein Y represents -CH2- or >C=0; R1 is selected from the group consisting of A1, A2 and A3; R2 represents dioxothiomorpholino moiety B1, piperazinyl moiety B2, azetidinyl moiety B3, or piperidinyl moiety B4; R3 is selected from the group consisting of H, halogen, and C1 -C4 alkyl; R4 is selected from the group consisting of C1 -C4 alkyl, C3-C4- cycloalkyl, C1 -C4 alkyl substituted with C1 -C4 alkoxy, and CHF2, and their pharmaceutically acceptable salts. Pharmaceutical compositions comprising said compounds and their use in the treatment of diseases of immune system, inflammatory diseases and cancer.

PYRIDO[3,2-d]PYRIMIDINE PI3K DELTA INHIBITOR COMPOUNDS AND METHODS OF USE

Formula I compounds, including stereoisomers, geometric isomers, tautomers, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting the delta isoform of PI3K, and for treating disorders mediated by lipid kinases such as inflammation, immunological disorders, and cancer. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.

Treatment of excessive osteolysis with indolinone compounds

Compounds of Formula I and Formula II, as described herein, are useful for treating excessive osteolysis, by inhibiting M-CSF mediated osteoclast development. The compounds also are useful for inhibiting phosphorylation of CSF1R, and for treating cancers that express CSF1R.

3-[4-Substituted heterocyclyl)-pyrrol-2-ylmethylidene]-2- indolinone derivatives as kinase inhibitors

The present invention relates to certain 3-[4-(substituted heterocyclyl)-pyrrol-2-ylmethylidene]-2-indolinone derivatives that inhibit kinases, in particular VEGFR and/or PDGFR kinases. Pharmaceutical compositions comprising these compounds, methods of treating diseases mediated by kinases utilizing pharmaceutical compositions comprising these compounds, and methods of preparing them are also disclosed.

Treatment of acute myeloid leukemia with indolinone compounds

A method of treating acute myeloid leukemia in patient positive for FLT-3-ITD is described. The treatment is accomplished by administration of a compound of Formula I or II as defined herein.