6963-32-2

Basic information

• Product Name: 2,3-dibromopropylammonium bromide
• Synonyms: 2,3-dibromopropylammonium bromide;2,3-Dibromopropane-1-amine·hydrobrominate;2,3-Dibromopropylamine·hydrobrominate;2,3-DibroMopropylaMine HydrobroMide;2,3-Dibromopropan-1-amine hydrobromide
• CAS NO: 6963-32-2
• Molecular Formula: BrH*C₃H₇Br₂N
• Molecular Weight: 297.81432
• EINECS: 230-159-3
• Mol File: 6963-32-2.mol
• Article Data: 10

Chemical Properties

• Melting Point: 164 °C
• Boiling Point: 224.2 °C at 760 mmHg
• Flash Point: 89.4 °C
• Appearance: /
• Density: 1.999g/cm³
• Vapor Pressure: 0.0924mmHg at 25°C
• Refractive Index: 1.556
• CAS DataBase Reference: 2,3-dibromopropylammonium bromide(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-dibromopropylammonium bromide(6963-32-2)
• EPA Substance Registry System: 2,3-dibromopropylammonium bromide(6963-32-2)

Safety Data

• Hazardous Substances Data: 6963-32-2(Hazardous Substances Data)

Usage

Uses

In tandem with Turbo Grignard (Aldrich product 656984) and an electrophilic trap, 2,3-Dibromo-propylamine hydrobromide generates a "spring loaded" electrophile, which is a convenient reagent for the installation of azetidine to secondary amines. This product is one of several synthetic useful reagents reported by Baran and coworkers on Strain-release amination.

InChI:InChI=1/C3H7Br2N/c4-1-3(5)2-6/h3H,1-2,6H2

Upstream product

• 107-11-9 1-amino-2-propene 
• 78888-18-3 N-tert-butoxycarbonylprop-2-en-1-amine 
• 106-98-9 1-butylene 

Downstream Products

• 160676-82-4 C₁₆H₁₆BrN 
• 302355-79-9 4-(azetidin-3-yl)morpholine 
• 244088-62-8 2-(bromomethyl)-1-(4-methylbenzenesulfonyl)aziridine 
• 5120-12-7 1-Benzenesulfonyl-2-(bromomethyl)ethylenimine 
• 188818-01-1 N-benzylidene-2,3-dibromopropylamine 
• 19540-05-7 1-azabicyclo<1.1.0>butane 
• 50487-77-9 N-(2,3-dibromopropyl)benzamide 
• 156697-66-4 N-benzylidene-2,3-dibromopropan-1-amine 
• 156697-72-2 2,3-dibromo-N-(4-chlorobenzylidene)propan-1-amine 
• 156697-67-5 (2,3-Dibromo-propyl)-[1-p-tolyl-meth-(E)-ylidene]-amine 

Relevant articles and documents

SOLID FORMS OF 3-((1R,3R)-1-(2,6-DIFLUORO-4-((1-(3-FLUOROPROPYL)AZETIDIN-3-YL)AMINO)PHENYL)-3-METHYL-1,3,4,9-TETRAHYDRO-2H-PYRIDO[3,4-B]INDOL-2-YL)-2,2-DIFLUOROPROPAN-1-OL AND PROCESSES FOR PREPARING FUSED TRICYCLIC COMPOUNDS COMPRISING A SUBSTITUTED PHENYL OR PYRIDINYL MOIETY, INCLUDING METHODS OF THEIR USE

Provided herein are solid forms, salts such as compound B, and formulations of 3-((lR,3R)-l-(2,6-difluoro-4-((l-(3-fluoropropyl) azetidin-3-yl)amino)phenyl)-3-methyl-l,3,4,9-tetrahydro-2H- pyrido[3,4-b]indol-2-yl)-2,2-difluoropropan-l-ol, processes and synthesis thereof, and methods of their use in the treatment of cancer.

An improved, gram-scale synthesis of protected 3-haloazetidines: Rapid diversified synthesis of azetidine-3-carboxylic acids

Azetidines are increasingly important heterocycles found in a variety of natural products and pharmaceutical compounds. Protected 3-haloazetidines, widely used and versatile building blocks in medicinal chemistry, have been prepared in a one-pot, gram-scale strain-release reaction of 1-azabicyclo[1.1.0]butane from commercially available starting materials. These intermediates were subsequently used to prepare a series of high value azetidine-3-carboxylic acid derivatives including the first reported synthesis of 1-(tert-butoxy-carbonyl)-3-((trifluoromethyl)thio)azetidine-3-carboxylic acid. (Figure pressented)

Carbonic anhydrase II as host protein for the creation of a biocompatible artificial metathesase

An artificial metathesase results from incorporation of an Hoveyda-Grubbs catalyst bearing an arylsulfonamide anchor within human carbonic anhydrase II. The optimization of the catalytic performance is achieved upon combining both chemical and genetic means. Up to 28 TONs were obtained within four hours under aerobic physiological conditions.