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302799-86-6

TCS 46B is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 5-[3-(4-benzylpiperidin-1-yl)prop-1-yn-1-yl]-1,3-dihydro-1,3-benzodiazol-2-one

    Cas No: 302799-86-6

  • USD $ 1.9-2.9 / Gram

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  • 302799-86-6 Structure

  • Basic information

    1. Product Name: TCS 46B
    2. Synonyms: TCS 46B;1,3-Dihydro-5-[3-[4-(phenylmethyl)-1-2H-benzimidazol-2-one
    3. CAS NO:302799-86-6
    4. Molecular Formula: C22H23N3O
    5. Molecular Weight: 345.444
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 302799-86-6.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 440.4±38.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.24±0.1 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: Store at RT
    8. Solubility: N/A
    9. PKA: 11.51±0.30(Predicted)
    10. CAS DataBase Reference: TCS 46B(CAS DataBase Reference)
    11. NIST Chemistry Reference: TCS 46B(302799-86-6)
    12. EPA Substance Registry System: TCS 46B(302799-86-6)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 302799-86-6(Hazardous Substances Data)

302799-86-6 Usage

Uses

TCS 46b is a subtype-selective NR1A/NR2B NMDA receptor antagonist.

Biological Activity

Orally active, subtype-selective NR1A/NR2B NMDA receptor antagonist (IC 50 values are 5.3, 35000 and > 100000 nM for NR1A/2B, NR1A/2A and NR1A/2C receptor subtypes respectively). Potentiates the effect of L-DOPA in 6-OHDA-lesioned rats following oral administration.

Check Digit Verification of cas no

The CAS Registry Mumber 302799-86-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,0,2,7,9 and 9 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 302799-86:
(8*3)+(7*0)+(6*2)+(5*7)+(4*9)+(3*9)+(2*8)+(1*6)=156
156 % 10 = 6
So 302799-86-6 is a valid CAS Registry Number.

302799-86-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-[3-(4-benzylpiperidin-1-yl)prop-1-ynyl]-1,3-dihydrobenzimidazol-2-one

1.2 Other means of identification

Product number -
Other names TCS 46B

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:302799-86-6 SDS

302799-86-6Downstream Products

302799-86-6Relevant articles and documents

Synthesis, radiosynthesis and in vivo evaluation of 5-[3-(4- benzylpiperidin-1-yl)prop-1-ynyl]-1,3-dihydrobenzoimidazol-2-[ 11C]one, as a potent NR1A/2B subtype selective NMDA PET radiotracer

Roger, Gaelle,Lagnel, Beatrice,Besret, Laurent,Bramoulle, Yann,Coulon, Christine,Ottaviani, Michelle,Kassiou, Michael,Bottlaender, Michel,Valette, Heric,Dolle, Frederic

, p. 5401 - 5408 (2007/10/03)

Recently, a new series of potent and highly subtype-selective 1-(heteroarylalkynyl)-4-benzylpiperidine antagonists of the NMDA receptors has been described by Pfizer Laboratories. In this series, 5-[3-(4-benzylpiperidin- 1-yl)prop-1-ynyl]-1,3-dihydrobenzo

Subtype-selective N-methyl-D-aspartate receptor antagonists: Synthesis and biological evaluation of 1-(heteroarylalkynyl)-4-benzylpiperidines

Wright,Gregory,Kesten,Boxer,Serpa,Meltzer,Wise,Espitia,Konkoy,Whittemore,Woodward

, p. 3408 - 3419 (2007/10/03)

4-[4-(4-Benzylpiperidin-1-yl)but-1-ynyl]phenol (8) and 4-[3-(4-benzylpiperidin-1-yl)prop-1-ynyl]-phenol (9) are potent NR1A/2B receptor antagonists (IC50 values 0.17 and 0.10 μM, respectively). Administered intraperitoneally, they both potentia

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