303091-98-7Relevant articles and documents
Synthesis and biological evaluation of novel ligustrazine-chalcone derivatives as potential anti-triple negative breast cancer agents
Chen, Shaobin,Huang, Jianan,Huang, Qinghui,Li, Yuanzhi,Luo, Yingqi,Wang, Chengxu,Wu, Wenhao,Yu, Lihong,Zha, Dailong,Zhang, Chao,Zhang, Jianye,Zhou, Wenmin
, (2021/07/21)
A series of novel ligustrazine-chalcone hybrids were synthesized and evaluated for their in vitro and in vivo antitumor activities. The results showed that most of these compounds exhibited significant in vitro cytotoxicity against MDA-MB-231, MCF-7, A549
E-N-(2-acetyl-phenyl)-3-phenyl-acrylamide targets abrin and ricin toxicity: Hitting two toxins with one stone
Chauhan, Vinita,Dhaked, Ram Kumar,Pathak, Uma,Phatak, Pooja,Saxena, Nandita
, (2021/09/04)
The efficacy of small molecule inhibitors (SMIs) against the enzymatic activity of Shiga toxin prompted the evaluation of their efficacy on related toxins viz. ricin and abrin. Ricin, like Shiga toxin, is listed as a category B bioweapon and belongs to th