3-Arylimino-2-indolones are potent and selective galanin GAL3 receptor antagonists
A series of 3-imino-2-indolones are the first published, high-affinity antagonists of the galanin GAL3 receptor. One example, 1,3-dihydro-1-phenyl-3-[[3-(trifluoromethyl)phenyl]imino]-2H-indol-2-one (9), was shown to have high affinity for the
Konkel, Michael J.,Lagu, Bharat,Boteju, Lakmal W.,Jimenez, Hermogenes,Noble, Stewart,Walker, Mary W.,Chandrasena, Gamini,Blackburn, Thomas P.,Nikam, Sham S.,Wright, Jon L.,Kornberg, Brian E.,Gregory, Tracy,Pugsley, Thomas A.,Akunne, Hyacinth,Zoski, Kim,Wise, Lawrence D.
PROCESSES AND POLYMORPHS OF DIARYL-INDOLONE GALR3 ANTAGONISTS
This invention relates to crystalline forms, as well as an amorphous form of Compound I [1-phenyl-3-[[3--(trifluoromethyl)phenyl]imino]-1H-indol-2-one], the processes for their preparation, compositions containing the same and the therapeutic use of such
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(2008/06/13)
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