303225-22-1

Basic information

• Product Name: 4-(CHLOROMETHYL)-3-(2,6-DICHLOROPHENYL)-5-METHYLISOXAZOLE
• Synonyms: BUTTPARK 91\12-45;4-(CHLOROMETHYL)-3-(2,6-DICHLOROPHENYL)-5-METHYLISOXAZOLE;4-(Chloromethyl)-3-(2,6-dichlorophenyl)-5-methyl-1,2-oxazole, 2-[4-(Chloromethyl)-5-methyl-1,2-oxazol-3-yl)]-1,3-dichlorobenzene
• CAS NO: 303225-22-1
• Molecular Formula: C₁₁H₈Cl₃NO
• Molecular Weight: 276.55
• Product Categories: Oxazole&Isoxazole
• Mol File: 303225-22-1.mol

Chemical Properties

• Melting Point: 61 °C
• Boiling Point: 379.6 °C at 760 mmHg
• Flash Point: 183.4 °C
• Appearance: /
• Density: 1.392 g/cm³
• Vapor Pressure: 1.26E-05mmHg at 25°C
• Refractive Index: 1.574
• CAS DataBase Reference: 4-(CHLOROMETHYL)-3-(2,6-DICHLOROPHENYL)-5-METHYLISOXAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(CHLOROMETHYL)-3-(2,6-DICHLOROPHENYL)-5-METHYLISOXAZOLE(303225-22-1)
• EPA Substance Registry System: 4-(CHLOROMETHYL)-3-(2,6-DICHLOROPHENYL)-5-METHYLISOXAZOLE(303225-22-1)

Safety Data

• Hazard Codes: C
• Statements: R34:Causes burns.
• Safety Statements: S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.; S36/37/39:Wear suitabl
• Hazardous Substances Data: 303225-22-1(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
4-(Chloromethyl)-3-(2,6-dichlorophenyl)-5-Methylisoxazole is used as a chemical intermediate for the synthesis of more complex organic compounds. Its unique structure, including the chloromethyl and dichlorophenyl groups, allows for various chemical reactions and modifications, making it a valuable component in the development of new molecules with specific properties.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 4-(Chloromethyl)-3-(2,6-dichlorophenyl)-5-Methylisoxazole may be used as a building block for the creation of new drug candidates. Its structural features could potentially contribute to the development of novel therapeutic agents, particularly in the areas of medicinal chemistry and drug design, where its reactivity and functional groups can be exploited to produce molecules with desired pharmacological properties.
Used in Chemical Research:
4-(Chloromethyl)-3-(2,6-dichlorophenyl)-5-Methylisoxazole is also used in chemical research as a subject of study for understanding its properties, reactivity, and potential applications. Researchers may investigate its behavior in various chemical reactions, its stability under different conditions, and its interactions with other molecules, which could lead to the discovery of new applications and uses in various fields.

InChI:InChI=1/C11H8Cl3NO/c1-6-7(5-12)11(15-16-6)10-8(13)3-2-4-9(10)14/h2-4H,5H2,1H3

Upstream product

• 3919-76-4 3-(2,6-dichloro-phenyl)-5-methyl-isoxazole-4-carboxylic acid 
• 175204-38-3 [3-(2,6-dichlorophenyl)-5-methyl-4-isoxazolyl]methanol 

Downstream Products

• 919285-21-5 (4-{2-[3-(2,6-dichloro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-ethoxy}-2-methyl-phenoxy)-acetic acid methyl ester 
• 870194-46-0 2-[3-(2,6-dichloro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-ethanol 

Relevant articles and documents

3,4,5-Trisubstituted isoxazoles as novel PPARδ agonists: Part 1

We report the identification of a novel series of trisubstituted isoxazoles as PPAR activators from a high-throughput screen. A series of structural optimizations led to improved efficacy and excellent functional receptor selectivity for PPARδ. The isoxazoles represent a series of agonists which display a scaffold that lies outside the typical PPAR agonist motif.

COMPOUNDS AND COMPOSITIONS AS PPAR MODULATORS

The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of the Peroxisome Proliferator-Activated Receptor (PPAR) families, particularly the activity of PPAR .