- Synthesis and characterization of various alkyl, aryl and hetero aryl substituted hydrazines and study of their biological activity
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Due to the presence of N-N linkage hydrazines are well-known for their diverse biological activity.N-N linkage has been used as a key structural motif in various bioactive agents. A series of aryl, alkyl and hetero aryl substituted hydrazine derivatives has been synthesized, for this diazotization of alkyl, aryl amines has been done, followed by reduction with stannous chloride or sodium sulfite. All synthesized compounds were characterized by elemental analysis, IR, 1H-NMR, Mass spectra and their biological activity has been studied.
- Gupta, Anil,Goklani, Poonam
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- Access to phthalazinones via palladium-catalyzed three-component cycloamino-carbonylation of 2-formylaryl tosylates, hydrazines and CO
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The palladium-catalyzed three-component cycloaminocarbonylation of 2-formylaryl tosylates with hydrazines and carbon monoxide has been established, which provides an efficient method for synthesis of substituted phthalazinones. In addition, by applying this protocol as the key step, Hydralazine can easily be synthesized in 65% yield.
- Liu, Bin,Zhang, Chunlei,Zhou, Xigeng
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p. 8282 - 8286
(2016/12/02)
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- Manufacture of pure hydralazine salts
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The present invention provides an improved process of preparing hydralazine hydrochloride, which involves the preparation of 1-chlorophthalazine salt and further reacting with hydrazine followed by purification of hydralazine hydrochloride, which is free of phosphate, does not contain any individual impurities more than 0.05%, total impurities less than 0.5%, and a hydrazine content of not more than 0.001%, and preferably less than 0.0003%. One benefit of improved purity is enhanced storage stability.
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Page/Page column 4; 6
(2008/06/13)
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- Synthesis of hydrazine derivatives of pyridazine
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The present invention relates to both a novel method of preparing hydralazine hydrochloride and to a novel method of preparing hydrazine derivatives of compounds containing a pyridazine ring, including, for example, pyridazines, phthalazines and other compounds containing the pyridazine ring.
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Page/Page column 7
(2008/06/13)
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- Stable hydrazalazine pharmaceutical compositions
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The present invention relates to stable and highly purified stable hydralazine hydrochloride compositions and stable hydralazine-containing pharmaceutical compositions. A sterile aqueous injectable pharmaceutical composition suitable for parenteral administration is described comprising a therapeutically effective dose of hydralazine hydrochloride in a pharmaceutically acceptable carrier or diluent wherein said hydralazine hydrochloride is essentially free of phthalazines, hydrazine and metal ions. In addition, a stable sterile aqueous pharmaceutical composition comprising hydralazine hydrochloride in a pharmaceutically acceptable salt or diluent is described that is colorless and has no visible particulate matter.
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Page/Page column 6-7
(2008/06/13)
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- Naphthalenone phthalazinylhydrazones
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Naphthalenone phthalazinylhydrazones of the formula: STR1 are disclosed. In the above formula R1 is hydrogen or alkyl, R2 is alkyl, preferably branched alkyl, or N, R1 and R2 taken together forming a heterocyclic ring. These compounds are useful as antihypertensive agents.
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