19064-69-8Relevant articles and documents
PHTHALAZINE DERIVATIVES
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, (2015/01/16)
Compounds of the formula (I), in which R1, X and n have the meanings indicated in Claim 1, are inhibitors of Tankyrase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous syst
Synthesis of new tetracyclic azaheteroaromatic cores via auto-tandem Pd-catalyzed and one-pot Pd- and Cu-catalyzed double C-N bond formation
Rauws, Tom R.M.,Biancalani, Claudio,De Schutter, Joris W.,Maes, Bert U.W.
experimental part, p. 6958 - 6964 (2010/10/01)
Inter- and intramolecular transition metal-catalyzed amination of 2-chloro-3-iodopyridine and 2,3-dibromopyridine, respectively, with benzodiazinamines yielded six hitherto unknown tetracyclic azaheteroaromatic cores. C-N bond formation was achieved via auto-tandem (Pd-catalyst) as well as one-pot (sequential use of a Pd- and Cu-catalyst) catalysis.
Hydrazination of Pyridazines and Phthalazines
Counotte-Potman, A.,Plas, H. C. van der
, p. 1259 - 1261 (2007/10/02)
It is shown by 15N-labelling techniques that hydrazination of pyridazines partly occurs according to a reaction pathway, involving addition of the nucleophile (hydrazine), ring opening and ring closure (SN(ANRORC)-mechanism).It is also proved that phthalazines undergo hydrazination without ring opening (SN(AE)-mechanism).
