- PHTHALAZINE DERIVATIVES
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Compounds of the formula (I), in which R1, X and n have the meanings indicated in Claim 1, are inhibitors of Tankyrase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous syst
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- Synthesis of new tetracyclic azaheteroaromatic cores via auto-tandem Pd-catalyzed and one-pot Pd- and Cu-catalyzed double C-N bond formation
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Inter- and intramolecular transition metal-catalyzed amination of 2-chloro-3-iodopyridine and 2,3-dibromopyridine, respectively, with benzodiazinamines yielded six hitherto unknown tetracyclic azaheteroaromatic cores. C-N bond formation was achieved via auto-tandem (Pd-catalyst) as well as one-pot (sequential use of a Pd- and Cu-catalyst) catalysis.
- Rauws, Tom R.M.,Biancalani, Claudio,De Schutter, Joris W.,Maes, Bert U.W.
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experimental part
p. 6958 - 6964
(2010/10/01)
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- Hydrazination of Pyridazines and Phthalazines
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It is shown by 15N-labelling techniques that hydrazination of pyridazines partly occurs according to a reaction pathway, involving addition of the nucleophile (hydrazine), ring opening and ring closure (SN(ANRORC)-mechanism).It is also proved that phthalazines undergo hydrazination without ring opening (SN(AE)-mechanism).
- Counotte-Potman, A.,Plas, H. C. van der
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p. 1259 - 1261
(2007/10/02)
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