- The robustness of a thermoset of a main-chain type polybenzoxazine precursor prepared through a strategy of A-A and B-B polycondensation
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A polybenzoxazine precursor, P(BF-bapp)-1, was prepared through a strategy of A-A and B-B polycondensation. The A-A monomer is 5,5′-methylenebis(2-hydroxybenzaldehyde), and the B-B monomer is 2,2-bis[4-(4-aminophenoxy)phenyl] propane (BAPP). The inherent
- Wang, Meng Wei,Jeng, Ru Jong,Lin, Ching Hsuan
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- Microwave assisted synthesis of novel methylenebis{2-[(1-benzyl/cyclohexyl-1H-1,2,3-triazol-4-yl)methoxy]chalcones} and their antibacterial activity
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A series of novel methylenebis{2-[(1-benzyl/cyclohexyl-1H-1,2,3-triazol-4-yl)methoxy]chalcones} (IVa-IVn) have been synthesized by the Click reaction and Claisen-Schmidt condensation of 5,5'-methylenebis[2-(prop-2-yn-1-yloxy)benzaldehyde] under microwave irradiation with high yields. All products have been characterized by spectral data including FT-IR, 1H, and 13C NMR, mass spectrometry, and tested for their antibacterial activity.
- Ramesh, S.,Ashok, D.,Linga Goud, G.,Prabhakar Reddy, V.
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- Synthesis, antimicrobial evaluation, and docking studies of some novel benzofuran based analogues of chalcone and 1,4-benzodiazepine
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A series of novel {5-[4-hydroxy-3-(4-phenyl-2,3-dihydro-1H-benzo[b][1,4]diazepin-2-yl)benzyl]- benzofuran-2-yl}(phenyl)methanones (5a–5g) were prepared by the condensation of (E)-3-{5-[(2- benzoylbenzofuran-5-yl)methyl]-2-hydroxyphenyl}-1-phenylprop-2-en-
- Shankar,Jalapathi,Ramesh,Kumar, A. Kishore,Ragavender,Bharath
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- Schiff bases-titanium (III) & (IV) complex compounds: Novel photocatalysts in Buchwald-Hartwig C–N cross-coupling reaction
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Nine novel Schiff bases were derived from salicylic aldehyde and oxalic aldehyde, isolated, and their molecular and spatial structure were explored by a set of experiments (IR, CNMR, HNMR, CHN, SEM, XRD) and theoretical simulation (DFT def2-TZVP). A high potential was predicted in metal cations chelating. The isolated organic species were applied as the ligands in the reaction of complex formation with titanium (III) chloride and (IV) bromide and 12 novel complexes were synthesized and studied experimentally and theoretically. Using the UV–vis spectroscopic titration, the solution stability of the complexes was indicated. Depending on the nature of the Schiff base ligand, their formation constants were calculated in the range of 6.84–17.32. Using the DFT def2-TZVP theoretical method together with the experimental spectroscopic data, the coordination types of the ligands were investigated, and the structure of the complexes was proposed. The photocatalytic ability of the isolated complexes was tested in the C-N cross-coupling reaction under sunlight. Complexes exhibited high visible-light photocatalytic activity for a wide range of aromatic and benzylic amines including electron-withdrawing and electron-donating groups from moderate to good yields ranging in 50–85 %. The use of an inexpensive, clean, and renewable energy source (visible light) is the superiority of the developed photocatalytic systems.
- Absalan, Yahya,Ghandi, Khashayar,Gholizadeh, Mostafa,Kovalchukova, Olga,Mahmoudi, Ghodrat,Sarvestani, Hossein Sabet,Shad, Nazanin Noroozi,Strashnov, Pavel
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- Biology-based flame-retardant epoxy resin precursor on basis of natural phenol monomers, method for preparing biology-based flame-retardant epoxy resin precursor and application thereof
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The invention discloses a biology-based flame-retardant epoxy resin precursor on the basis of natural phenol monomers. The biology-based flame-retardant epoxy resin precursor is of a structure shown as a following formula (I). A method for preparing the b
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Paragraph 0032; 0033; 0039; 0040; 0044; 0045
(2019/05/22)
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- Structural Identification of Products from the Chloromethylation of Salicylaldehyde
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In the functionalization of salicylaldehyde to give 5-(chloromethyl)salicylaldehyde, two byproducts [5-(hydroxymethyl)salicylaldehyde and 5,5′-methylenebis(salicylaldehyde)] were also isolated. Detailed characterizations and structural analyses of all three products by single-crystal X-ray diffraction, multinuclear NMR spectroscopy, high-resolution mass spectrometry, and IR spectroscopic techniques are presented and discussed. A strategy is presented for the preferential isolation of the two byproducts through column chromatography.
- Kadwa, Ebrahim,Friedrich, Holger B.,Bala, Muhammad D.
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- Design and synthesis of bis-pyrimidines linked with thiazolidin-4-one as new antibacterial agents
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A series of novel 3-4-[2-hydroxy-5-(4-hydroxy-3-2-[2-(aryl)-4-oxo-1,3-thiazolan-3-yl]-6-phenyl-4-pyrimidinylbenzyl)phenyl]-6-phenyl-2-pyrimidinyl-2-(aryl)-1,3-thiazolan-4-ones 5(a-j) have been synthesized and assayed for their antibacterial activity again
- Sanjeeva Reddy,Nagaraj,Yakub,Kalyani
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p. 1913 - 1918
(2019/08/08)
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- Preparation method of novel dispiropyran chromophore
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The invention discloses a preparation method of novel dispiropyran chromophore. Salicylaldehyde and trioxymethylene are used as raw materials, glacial acetic acid is used as a solvent, thick sulfuricacid is used as a catalyst to synthesize a salicylaldehy
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Paragraph 0044; 0045
(2018/12/14)
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- Metal-free synthesis of calixsalen-type cavitands for the recognition of fluoride ion
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Novel calixsalen-type cavitands have been synthesized using metal-free synthesis from simple and inexpensive materials, such as ethylenediamine and 5,5′-methylene-bis-salicylaldehyde derivatives. The cavitand 1 containing salen functionality recognizes fl
- Desai, Arpita,Rana, Dharti
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supporting information
p. 291 - 301
(2018/02/09)
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- Synthesis and antimicrobial activity of novel substituted 4-[3-(1H-benzimidazol-2-yl)-4-hydroxybenzyl]-2-(1H-benzimidazol-2-yl)phenol derivatives
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A series of novel substituted bis-benzimidazole derivatives were synthesized by reaction of 5,5′-methylenebis(2-hydroxybenzaldehyde) with various substituted o-phenylenediamines in glacial acetic acid. The structure of the newly synthesized compounds was elucidated by 1H and 13C NMR, FT-IR, and MS spectra, and their antimicrobial activity against gram positive and gram negative bacteria and antifungal activity were evaluated. The thienyl-substituted derivative showed significant activity against Bacillus licheniformis. Bacillus subtilis, Staphylococcus aureus, Klebsiella pneumonia (bacteria), and Fusarium solani (fungi). The activities of the fluoro-substituted substituted derivative against some bacterial strains and of the thienyl-substituted derivative against fungi were found to be similar to those of standard drugs.
- Anil,Shankar,Bharath,Jalapathi
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p. 2648 - 2653
(2017/12/26)
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- Synthesis and Antimicrobial Activity of Novel Substituted 4-[3-(1H-Benzimidazol-2-yl)-4-hydroxybenzyl]-2-(1H-benzimidazol-2-yl)phenol Derivatives
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A series of novel substituted bis-benzimidazole derivatives were synthesized by reaction of 5,5′-methylenebis(2-hydroxybenzaldehyde) with various substituted o-phenylenediamines in glacial acetic acid. The structure of the newly synthesized compounds was elucidated by 1H and 13C NMR, FT-IR, and MS spectra, and their antimicrobial activity against gram positive and gram negative bacteria and antifungal activity were evaluated. The thienyl-substituted derivative showed significant activity against Bacillus licheniformis, Bacillus subtilis, Staphylococcus aureus, Klebsiella pneumonia (bacteria), and Fusarium solani (fungi). The activities of the fluoro-substituted substituted derivative against some bacterial strains and of the thienyl-substituted derivative against fungi were found to be similar to those of standard drugs.
- Anil,Shankar,Bharath,Jalapathi
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p. 3017 - 3022
(2018/02/21)
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- Crystallization-induced light-emission enhancement of diphenylmethane derivatives
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A family of diphenylmethane derivatives has been synthesized and their luminescence properties characterized. While in solution the compounds are weakly emissive, showing no aggregation-induced emission enhancement, the crystals of three dialkyl 5,5′-methylenebis(2-hydroxybenzoate) samples exhibit intense emission. This emission enhancement upon crystallization is ascribed to particular molecular packing, which stiffens the structure of the compounds via hydrogen bonds, preventing consecutive π-π interactions.
- Guieu, Samuel,Rocha, Jo?o,Silva, Artur M.S.
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p. 9329 - 9334
(2013/10/01)
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- Synthesis of a benzoxazine with precisely two phenolic OH linkages and the properties of its high-performance copolymers
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A phenolic OH-containing benzoxazine (F-ap), which cannot be directly synthesized from the condensation of bisphenol F, aminophenol, and formaldehyde by traditional procedures, has been successfully prepared in our alternative synthetic approach. F-ap was
- Hsuan Lin, Ching,Feng, Yu Ren,Dai, Kang Hong,Chang, Hou Chien,Juang, Tzong Yuan
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p. 2686 - 2694
(2013/07/05)
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- Steric hindrance control synthesis of primary amine-containing benzoxazines and properties of the resulting poly(benzoxazine imide) thermosetting films
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Primary amine-containing benzoxazines 3 and 6 were prepared from an unsymmetrical diamine 1, in which the amine group ortho to diethyl substituents, the hindered amine, is not reactive toward aldehyde at room temperature. Based on 6, three poly(benzoxazine imide) (PBzI) thermosets were prepared by low-temperature polymerization, followed by thermal treatment. Experimental data show that incorporating thermosetting benzoxazine into a polyimide increased the Tg, tensile modulus, dimensional stability, flame retardancy, and contact angle without sacrificing too much in thermal stability.
- Wang, Meng Wei,Lin, Ching Hsuan,Juang, Tzong Yuan
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p. 8853 - 8863
(2014/01/06)
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- Transition metal coordination polymers: Synthesis and catalytic study for hydroxylation of phenol and benzene
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New coordination polymers of Ni(II) and Cu(II) of the polymeric salen-type Schiff base ligand derived from the condensation of 5,5′-methylene bis-(salicyaldehyde) with 1,2-diaminopropane yielded N,N′-1,2- propylenebis(5-methylenesalicylidenamine) abbrevia
- Abbo, Hanna S.,Titinchi, Salam J.J.
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scheme or table
p. 148 - 155
(2012/09/22)
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- Efficient microwave-assisted synthesis and antitumor activity of novel 4,4′-methylenebis[2-(3-aryl-4,5-dihydro-1H-pyrazol-5-yl)phenols]
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Two new series of 4,4′-methylenebis[2-(3-aryl-4,5-dihydro-1H-pyrazol- 5-yl)phenols] 4 and methylenebis-2-(3-aryl-4,5-dihydro-1H-pyrazol-5-yl)-4,1- phenylene diacetates 5 have been efficiently prepared starting from the commercially available salicylaldehy
- Insuasty, Braulio,García, Angélica,Quiroga, Jairo,Abonia, Rodrigo,Ortiz, Alejandro,Nogueras, Manuel,Cobo, Justo
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scheme or table
p. 2436 - 2440
(2011/06/21)
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- Synthesis and biological evaluation of a novel series of bis-salicylaldehydes as mushroom tyrosinase inhibitors
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A series of novel bis-salicylaldehydes were synthesised and evaluated as tyrosinase inhibitors using a tyrosinase-dependent l-DOPA oxidation assay. The bis-salicylaldehydes exhibited greater inhibitory activity than salicylaldehyde. Our data suggests that
- Delogu, Giovanna,Podda, Gianni,Corda, Marcella,Fadda, Maria Benedetta,Fais, Antonella,Era, Benedetta
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body text
p. 6138 - 6140
(2010/11/18)
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- Synthesis and in vitro study of methylene-bis-tetrahydro[1,3]thiazolo[4,5-c]isoxazoles as potential nematicidal agents
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A series of methylene-bis-tetrahydro[1,3]thiazolo[4,5-c]isoxazoles 6 were synthesized by the reaction of chalcone derivative of methylene-bis-thiazolidinone 5 with hydroxylamine hydrochloride. The chemical structures of newly synthesized compounds were el
- Srinivas, Avula,Nagaraj, Adki,Reddy, Cherkupally Sanjeeva
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scheme or table
p. 2353 - 2358
(2010/07/05)
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- Design and synthesis of novel methylene-bis-fused pyrazoles as biologically active molecules
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A series of novel methylene-bis-fused pyrazoles 12a-e and methylene-bis-2-(4-methylsulfonyl)-phenyl substituted fused pyrazoles 15a-d have been synthesized by the reaction of methylene-bis-aryl-6-hydroxymethylene-2- cyclohexenones 10 with hydrazine hydrat
- Reddy, Ch. Sanjeeva,Srinivas,Sunitha,Nagaraj
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scheme or table
p. 1303 - 1309
(2011/02/16)
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- Synthesis, nematicidal and antimicrobial properties of bis-[4-methoxy-3-[3- (4-fluorophenyl)-6-(4-methylphenyl)-2(aryl)-tetrahydro-2H-pyrazolo[ 3,4-d]thiazol-5-yl]phenyl]methanes
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A new series of bis-[4-methoxy-3-[3-(4-fluorophenyl)-6-(4-methylphenyl)-2- (aryl)-3,3a,5,6-tetrahydro-2H-pyrazolo[3,4-d][1,3]thiazol-5-yl]phenyl]methanes 6a-r was synthesized by the reaction of arylidine derivative of methylene-bis-thiazolidinones 5a-c wi
- Sanjeeva Reddy, Cherkupally,Srinivas, Avula,Nagaraj, Adki
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scheme or table
p. 685 - 693
(2010/02/28)
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- Synthesis and in vitro study of a new class of methylenebis-4,6- diarylbenzo[d]isoxazoles as potential antifungal agents
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(Chemical Equation Presented) A new class of methylene-bis-4,6- diarylbenzo[d]isoxazoles 8a-i was synthesized by the reaction of methylene-bis-aryl-6-hydroxymethylene-2-cyclohexenone 6 with hydroxylamine hydrochloride, followed by aromatization with DDQ. Chemical structures of the newly synthesized compounds were elucidated by their IR, 1H NMR, 13C NMR, MS, and elemental analyses. Furthermore, all the compounds were screened for their antifungal activity against various fungi and compared with their monomeric compounds. Among the synthesized compounds, 8b, 8g, and 8i were found to be the most active against Candida albicans (ATCC 10231), Aspergillus fumigatus (HIC 6094), Trichophyton rubrum (IFO 9185), and Trichophyton mentagrophytes (IFO 40996). It is interesting to note that the compounds 8a, 8g, and 8i showed fungicidal activity toward C. albicans at the concentration of 3.12 lg/mL, which is less than the concentration of standard Amphotericin B.
- Srinivas,Nagaraj,Sanjeeva Reddy
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scheme or table
p. 497 - 502
(2009/08/17)
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- Synthesis and biological evaluation of novel methylene-bis-thiazolidinone derivatives as potential nematicidal agents
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(Chemical Equation Presented) In a one pot procedure, a series of novel methylene-bis-thiazolidinone derivatives 5 and 6 was prepared by condensation of 5-(3-formyl-4-methoxybenzyl)-2-methoxybenzaldehyde 3 with mercapto acids and primary aromatic amines 4
- Srinivas,Nagaraj,Sanjeeva Reddy
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p. 999 - 1003
(2008/09/21)
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- Synthesis of novel methylene-bis-isoxazoles as potential fungicidal agents
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A series of novel methylene-bis-chalcones 3 was prepared by the Claisen-Schmidt condensation of 5,5'-methylene-bis-salicylaldehye 2 with various acetophenones, subsequent condensation of compound 3 with hydroxylamine hydrochloride gave the corresponding n
- Sanjeeva Reddy,Nagaraj
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body text
p. 289 - 294
(2009/04/11)
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- Synthesis and biological study of novel methylene-bis-chalcones and substituted methylene-bis-pyrimidines/pyrimidinones
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(Chemical Equation Presented) A series of novel methylene-bis-chalcones was prepared by the reaction of 5,5′-methylene-bis-salicylaldehyde with different acetophenones, subsequent treatment of methylene-bis-chalcones with urea/thiourea gave the correspond
- Nagaraj, Adki,Reddy, Cherkupally Sanjeeva
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p. 1181 - 1185
(2008/04/12)
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- Synthesis and characterization of 'calixsalens': A new class of macrocyclic chiral ligands
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Template directed reaction of dialdehydes and (R,R)- or (S,S)-1,2-diaminocyclohexane affords a practical route to chiral, metal-free macrocyclic salen dimers which have a novel calixarene-like structure and show catalytic activity for enantioselective epo
- Li, Zengmin,Jablonski, Chet
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p. 1531 - 1532
(2007/10/03)
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