- Covalent Functionalization of Carbon Nitride Frameworks through Cross-Coupling Reactions
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A new and simple synthetic route is introduced to covalently functionalize the carbon nitride (CN) framework by the implementation of halogenated phenyl groups (Cl, Br and I), which serve as a chemically reactive center, within the CN framework. The coval
- Sun, Jingwen,Phatake, Ravindra,Azoulay, Adi,Peng, Guiming,Han, Chenhui,Barrio, Jesús,Xu, Jingsan,Wang, Xin,Shalom, Menny
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- 2,4,6-trisubstituted-1,3,5-s-triazine compound and preparation and application thereof
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The invention provides a 2,4,6-trisubstituted-1,3,5-s-triazine compound as well as preparation and application thereof, and biguanide or dimethyl biguanide hydrochloride is used as an initial raw material to react with a cyano compound under an alkaline condition to prepare the 2,4,6-trisubstituted-1,3,5-s-triazine compound. The invention provides a simple and convenient synthetic method of a 2,4,6-trisubstituted-1,3,5-s-triazine compound, and the compound provided by the invention can be applied to preparation of an anti-myelogenous leukemia medicine, namely an enasidenib medicine. Compared with the prior art, the method for preparing the enasidenib has the advantages that two-step reaction is reduced, the use of a halogenating reagent is avoided, and the method is a green and environment-friendly chemical process. The structural formula I is shown in the specification.
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Paragraph 0028-0029; 0061-0062
(2021/10/05)
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- Synthesis, molecular docking studies, and in vitro evaluation of 1,3,5-triazine derivatives as promising antimicrobial agents
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The six-membered ring heterocycle 1,3,5-triazine and its derivatives have attracted considerable attention as they have proven to be excellent bioactive herbicides, cancer agents, etc. A series of 1,3,5-triazine derivatives (3a-o) were synthesized by a single step reaction and characterized by 1H NMR, 13C NMR, and mass spectrometry analysis. Antimicrobial screening of title compounds (3a-o) was examined against five bacterial and two fungal strains. In vitro study revealed that the freshly synthesized 6-(thiazol-4-yl)-1,3,5-triazine-2,4-diamine (3o) showed good antibacterial growth inhibition against E. coli, K. pneumoniae, and A. baumannii bacterial strains, and even the fungi C. neoformans. Molecular docking studies were performed on the X-ray crystal structure of E. coli 24 kDa domain in complex with clorobiocin (PDB code: 1KZN; resolution 2.30 ?) using Surflex-Dock program of Sybyl-X software. The results obtained are very encouraging.
- Bugarin, Alejandro,Joshi, Shrinivas D.,Lewis, Abby M.,Noonikara-Poyil, Anurag,Patil, Shivaputra A.,Patil, Siddappa A.,Patil, Vikrant
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- Design of bis(acylamino)triazine containing ruthenium-acetylides as self-complementary supramolecular units
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A series of systematically varied 'rigid-rod' octahedral ruthenium-acetylide complexes, bearing conjugated bis(acylamino)triazine (DAT) substituents capable of ADAD-DADA pairing, of general formula trans-[(dppe) 2Ru(Cl)(CC-C6H4
- Ouerfelli, Ins,Gatri, Rafik,Lotfi Efrit, Mohamed,Dua, Neerja,Perruchon, Johann,Golhen, Stéphane,Toupet, Lo?c,Fillaut, Jean-Luc
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scheme or table
p. 670 - 675
(2011/03/18)
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