- TETRAHYDROQUINOLINE COMPOSITIONS AS BET BROMODOMAIN INHIBITORS
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The present invention relates to inhibitors of bromo and extra terminal (BET) bromodomains that are useful for the treatment of cancer, inflammatory diseases, diabetes, and obesity, having Formula (I): wherein W, X, Y, Z, R1, R2, R5, and R8 are as described herein.
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Paragraph 0627
(2015/06/03)
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- Selective reductive cleavage of 2,3-epoxybromides by the InCl 3-NaBH4 reagent system
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A combination of sodium borohydride and a catalytic amount of indium(III) chloride in acetonitrile reduces 2,3-epoxybromides to the corresponding allylic alcohols in good yields involving reduction of the bromo moiety followed by selective C-O bond cleavage through a radical process. Several aromatic, cyclic and open-chain bromoepoxides successfully participated in this reaction.
- Ranu, Brindaban C.,Banerjee, Subhash,Das, Arijit
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p. 8579 - 8581
(2007/10/03)
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- Fragmentation of Cyclic Carboxonium Ions, IV. - Synthesis of β-Oxa-γ, δ-enones
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The proton-catalyzed fragmentation of 4-methylene-1,3-dioxolanes 2 by weak acids (pK > 4.3) or weak acidic ion exchangers leads in good yields to β-oxa-γ, δ-enones 5 which are thus easily and generally available for the first time.
- Mattay, Jochen,Thuenker, Walter,Scharf, Hans-Dieter
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p. 1105 - 1117
(2007/10/02)
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