305822-55-3Relevant articles and documents
GLUCOCORTICOID RECEPTOR MODULATORS
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, (2018/03/25)
The present invention provides non-steroidal compounds of formula I which are selective modulators (i.e., agonists and antagonists) of a steroid receptor, specifically, the glucocorticoid receptor. The present invention also provides pharmaceutical compos
Glucocorticoid receptor modulators
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Page 26, (2010/01/31)
The present invention provides non-steroidal compounds of Formula I, and prodrugs and pharmaceutically acceptable salts thereof, which are selective modulators (e.g., agonists, partial agonists and antagonists) of a steroid receptor, specifically, the glucocorticoid receptor. The present invention also provides pharmaceutical compositions containing these compounds and methods for using these compounds to treat animals requiring glucocorticoid receptor agonist or antagonist therapy. Glucocorticoid receptor modulators are useful to treat diseases, such as obesity, diabetes, inflammation and others as described below. The present invention also provides processes for preparing these compounds.
Glucocorticoid receptor modulators
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Example 3, (2010/11/29)
The present invention provides non-steroidal compounds of Formula I, including prodrugs and pharmaceutically acceptable salts thereof, which are selective modulators (e.g., agonists, partial agonists and antagonists) of a steroid receptor, specifically, the glucocorticoid receptor. The present invention also provides pharmaceutical compositions containing these compounds and methods for using these compounds to treat animals requiring glucocorticoid receptor agonist or antagonist therapy. Glucocorticoid receptor modulators are useful to treat diseases, such as obesity, diabetes, inflammation and others as described below. The present invention also provides processes for preparing these compounds.
Discovery of potent, nonsteroidal, and highly selective glucocorticoid receptor antagonists
Morgan, Bradley P.,Swick, Andrew G.,Hargrove, Diane M.,LaFlamme, Janet A.,Moynihan, Melinda S.,Carroll, Richard S.,Martin, Kelly A.,Lee, Eunsun,Decosta, Debra,Bordner, Jon
, p. 2417 - 2424 (2007/10/03)
An approach to the computer-assisted, pharmacophore design of nonsteroidal templates for the glucocorticoid receptor (GR) that contained an element of pseudo-C2 symmetry was developed. The enatiomer of the initial design, 1Ra, and not the designed molecul