305851-84-7

Basic information

• Product Name: 6-phenyl-5,6-dihydrobenzo[4,5]imidazo[1,2-c]quinazoline
• Synonyms: 6-phenyl-5,6-dihydrobenzo[4,5]imidazo[1,2-c]quinazoline
• CAS NO: 305851-84-7
• Molecular Formula: C₂₀H₁₅N₃
• Molecular Weight: 297.3532
• Mol File: 305851-84-7.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6-phenyl-5,6-dihydrobenzo[4,5]imidazo[1,2-c]quinazoline(CAS DataBase Reference)
• NIST Chemistry Reference: 6-phenyl-5,6-dihydrobenzo[4,5]imidazo[1,2-c]quinazoline(305851-84-7)
• EPA Substance Registry System: 6-phenyl-5,6-dihydrobenzo[4,5]imidazo[1,2-c]quinazoline(305851-84-7)

Safety Data

• Hazardous Substances Data: 305851-84-7(Hazardous Substances Data)

Upstream product

• 13275-42-8 2-(2-bromophenyl)-benzimidazole 
• 5805-39-0 2-(aminophenyl)benzimidazole 
• 100-52-7 benzaldehyde 

Relevant articles and documents

A microwave-assisted copper-mediated tandem approach for fused quinazoline derivatives

A method for the microwave-assisted copper-mediated oxidative coupling reaction of different aldehydes and quinazolines/benzimidazoles has been developed for the synthesis of fused-polycyclic systemsvianew C-N bond formation. The current methodology involves the use of environmentally benign NH4OAc as the amine source in the presence of 2-propanol as the solvent. This novel tandem reaction approach offers a rapid and straightforward access to complex fused quinazoline derivatives in an efficient manner.

Synthesis, characterization, computational studies and DPPH scavenging activity of some triazatetracyclic derivatives

Some dihydrobenzo[4,5]imidazo[1,2-c]quinazolines have been synthesized from aldehydes and ketones, using the ketones as both reagents and solvents and tetrahydrofuran (THF) as the solvent for the aldehydes, to yield the triazatetracyclics. The compounds h

Synthesis, characterization and biological activity studies on 6-p-dimethylaminophenyl-5,6-dihydrobenzoimidazo [1,2-c]quinazoline: Crystal structure of the title compound and comparative study with related derivatives

Reaction of o-aminophenylbenzimidazole with p-dimethylaminobenzaldehyde yielded 6-p-dimethylamin-ophenyl-5,6-dihydrobenzoimidazo[ 1,2-c]quinazoline, which was characterized by elemental analysis, IR, UV-Vis, 1H NMR, 13C NMR, mass spectral studies and X-ray crystal structure analysis. Studies on the antimicrobial activity of the compound revealed that it is active against fungus Yeast but not Bacillus subtilis. The compound crystallized in the space group P21/n with the unit cell parameters a = 10.652(2) A, b = 11.002(2) A, c = 15.753(2) A, β = 109.29(2)° and the structure was refined to an R-factor of 0.0479. The hydropyrimidine ring in the quinazoline moiety is in skew-boat conformation. The dimethylamino group attached to phenyl ring is in conjugation with it. The structure was stabilized by intermolecular C-H-N interactions. A few of the related quinazolines (6-p-hydroxyphenyl-5,6-dihydrobenzoimidazo [1,2-c]quinazoline; 6-phenyl-5,6-dihydrobenzoimidazo[1,2-c]quinazoline; 6-pyridyl-5,6- dihydrobenzoimidazo[1,2-c]quinazoline; 6-furyl-5,6-dihydrobenzoimidazo[1,2-c] quinazoline) were also examined for their biological activity, in addition to their characterization by IR, UV-Vis, JH and 13C NMR spectral studies along with structural comparison. Springer Science+Business Media, LLC 2011.