- Benzofuran derivatives
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The present invention provides a compound represented by the following formula (I): wherein: Ring A represents an optionally substituted piperazine ring, an optionally substituted morpholine ring, or an optionally substituted homopiperazine ring;R1 and R2 are the same or different from each other, and represent a hydrogen atom or optionally substituted lower alkyl;R3 and R4 are the same or different from each other, and represent a hydrogen atom or halogenated or non-halogenated lower alkyl;R5 to R7 are the same or different from each other, and represent a hydrogen atom, hydroxy, optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkoxy, optionally substituted cycloalkyl, optionally substituted aryl, an optionally substituted aromatic heterocyclic ring, optionally substituted amino, or acyl; and represents a single bond or double bond, or a salt thereof.
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Page/Page column 78
(2010/09/18)
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- FUROISOQUINOLINE DERIVATIVES, PROCESS FOR PRODUCING THE SAME AND USE THEREOF
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A compound having a partial structure represented by Formula: or a salt thereof has an excellent phosphodiesterase (PDE) IV-inhibiting effect, and is useful as a prophylactic or therapeutic agent against inflammatory diseases, for example, bronchial asthma, chronic obstructive pulmonary disease (COPD), rheumatoid arthritis, autoimmune disease, diabetes and the like.
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- Mo(CO)6 catalyzed one-pot conversion of allyl aryl ethers to dihydrobenzofurans
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Molybdenum hexacarbonyl effectively catalyses a tandem Claisen rearrangement-cyclization reaction of allyl aryl ethers to give good yields of dihydrobenzofurans.
- Bernard, Angela M.,Cocco, Maria T.,Onnis, Valentina,Piras, Pier P.
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- UNEXPECTED IODINE CATALYZED CYCLIZATION FOR SYNTHESIS OF 2,2-DIALKYL-2,3-DIHYDROBENZOFURANS
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2-(β-Methylallyl)phenol and 2-isobutenylphenol derivatives were easily cyclized to 2,2-dimethyl-2,3-dihydrobenzofurans in the presence of a catalytic amount of iodine without any formation of iodinated products.
- Kim, Kyoung Mahn,Ryu, Eung K.
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p. 219 - 224
(2007/10/02)
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- ONE-POT SYNTHESES OF 2,3-DIHYDRO-2,2-DIMETHYLBENZOFURAN DERIVATIVES
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A tandem Claisen rearrangement-cyclization reaction of aryl methallyl ethers afforded the corresponding 2,3-dihydro-2,2-dimethylbenzofuran derivatives at -70 deg C with aluminium chloride.
- Kim, Kyoung Mahn,Kim, Hyoung Rae,Ryu, Eung K.
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p. 497 - 505
(2007/10/02)
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