306776-28-3

Basic information

• Product Name: 2-Oxazolidinone, 5-acetyl-4-(1-methylethyl)-, (4R,5S)- (9CI)
• Synonyms: 2-Oxazolidinone, 5-acetyl-4-(1-methylethyl)-, (4R,5S)- (9CI)
• CAS NO: 306776-28-3
• Molecular Formula: C8H13NO3
• Molecular Weight: 171.19372
• Product Categories: ACETYLGROUP;ISOPROPYL
• Mol File: 306776-28-3.mol

Chemical Properties

• Boiling Point: 362.4±31.0 °C(Predicted)
• Appearance: /
• Density: 1.099±0.06 g/cm3(Predicted)
• PKA: 11.50±0.60(Predicted)
• CAS DataBase Reference: 2-Oxazolidinone, 5-acetyl-4-(1-methylethyl)-, (4R,5S)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Oxazolidinone, 5-acetyl-4-(1-methylethyl)-, (4R,5S)- (9CI)(306776-28-3)
• EPA Substance Registry System: 2-Oxazolidinone, 5-acetyl-4-(1-methylethyl)-, (4R,5S)- (9CI)(306776-28-3)

Safety Data

• Hazardous Substances Data: 306776-28-3(Hazardous Substances Data)

Upstream product

• 32315-10-9 bis(trichloromethyl) carbonate 
• 1669-43-8 (E)-4-isopropylbut-3-en-2-one 
• 105838-14-0 tert-butyl N-tosyloxycarbamate 
• 306776-20-5 (3S,4R)-3-hydroxy-4-(4-methoxyphenylamino)-5-methylhexan-2-one 
• 306776-21-6 (4R,5S)-5-acetyl-4-isopropyl-3-(4-methoxyphenyl)oxazolidin-2-one 

Downstream Products

• 1381884-80-5 (4R,5S)-3-(4-chlorobenzoyl)-4-isopropyl-5-(2,5,5-trimethyl-[1,3]-dioxan-2-yl)oxazolidin-2-one 
• 643022-64-4 Acetic acid (4R,5S)-4-isopropyl-2-oxo-oxazolidin-5-yl ester 

Relevant articles and documents

Formal asymmetric enone aminohydroxylation: Organocatalytic one-pot synthesis of 4,5-disubstituted oxazolidinones

A formal asymmetric organocatalytic aminohydroxylation reaction of enones has been achieved via an aziridination-double SN2 sequence. As a part of the reaction design, the generated amino alcohol products are isolated as the corresponding oxazolidinones in good yields and excellent stereoselectivities.

Highly Enantioselective Synthesis of 1,2-Amino Alcohol Derivatives via Proline-Catalyzed Mannich Reaction

Here we report a new catalytic asymmetric synthesis of oxazolidin-2-ones 4 and Cbz-protected 1,2-amino alcohols 5. Our sequence is based on the chemistry of previously unknown 5-acyloxy-oxazolidin-2-ones, which are obtained via proline-catalyzed direct asymmetric three-component Mannich reaction and Baeyer-Villiger oxidation.