105838-14-0

Basic information

• Product Name: N-Boc-O-tosyl hydroxylamine
• Synonyms: N-Boc-O-tosyl hydroxylamine;Carbamic acid, [[(4-methylphenyl)sulfonyl]oxy]-, 1,1-dimethylethyl ester
• CAS NO: 105838-14-0
• Molecular Formula: C₁₂H₁₇NO₅S
• Molecular Weight: 287.34
• Mol File: 105838-14-0.mol
• Article Data: 15

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: N-Boc-O-tosyl hydroxylamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-Boc-O-tosyl hydroxylamine(105838-14-0)
• EPA Substance Registry System: N-Boc-O-tosyl hydroxylamine(105838-14-0)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36/37/38-43
• Safety Statements: 26-36/37
• WGK Germany: 3
• Hazardous Substances Data: 105838-14-0(Hazardous Substances Data)

Usage

Uses

Electrophilic N-amination of aryl and alkyl amines.

Upstream product

• 24608-52-4 tert-butyl chloroformate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 870-46-2 t-butoxycarbonylhydrazine 
• 1070-19-5 N-(tert-butyloxycarbonyl) azide 
• 36016-38-3 tert-Butyl N-hydroxycarbamate 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 1254591-73-5 tert-butyl pivaloyl(N-tosyloxy)carbamate 
• 208245-82-3 tert-butyl pyrrolidin-1-ylcarbamate 
• 150884-54-1 N-(tert-butoxycarbonylamino)morpholine 
• 928053-39-8 tert-butyl 2-(2-fluorophenyl)hydrazine-1-carboxylate 
• 1341203-32-4 tert-butyl 2-[4-(propan-2-yl)phenyl]hydrazinecarboxylate 
• 1341203-34-6 tert-butyl 2-[3-(trifluoromethyl)phenyl]hydrazinecarboxylate 
• 848153-27-5 N'-(4-methoxyphenyl)hydrazinecarboxylic acid tert-butyl ester 
• 476362-41-1 N'-ethylhydrazinecarboxylic acid tert-butyl ester 
• 92491-67-3 tert-butyl 2-(4-nitrophenyl)hydrazine-1-carboxylate 
• 16689-35-3 tert-butyl 2-(isopropyl)hydrazinecarboxylate 
• 60295-52-5 tert-butyl 2-(tert-butyl)hydrazinecarboxylate 
• 192725-90-9 tert-butyl 2-(prop-2-en-1-yl)hydrazinecarboxylate 
• 69353-16-8 tert-butyl 2-(1-phenylethyl)hydrazine-1-carboxylate 
• 1341203-29-9 tert-butyl 2-(2,6-dimethylphenyl)hydrazinecarboxylate 

Relevant articles and documents

α-Nitrosostyrenes as Three-Atom Units for the (3+1) Cyclization Reaction: Facile Access to 2,3-Dihydrodiazete N-Oxides and Their Diversified Synthetic Conversions

An unprecedented (3+1) cyclization of α-nitrosostyrenes, generated in situ from α-bromooximes, and N-tosyloxycarbamates was developed, which enables the synthesis of a range of structurally unique and hitherto unexplored 2,3-dihydrodiazete N-oxides in mod

Novel quinoline derivative inhibitor

The invention provides a novel quinoline derivative inhibitor, which has a structure represented by the following general formula (I). According to the invention, the compound provided by the invention can selectively inhibit tyrosine kinase TAM family/an

FMOC PROTECTED (2S)-2-AMINO-8-[(1,1-DIMETHYLETHOXY)AMINO]-8-OXO-OCTANOIC ACID, (S)-2-AMINO-8-OXONONANOIC ACID AND (S)-2-AMINO-8-OXODECANOIC ACID FOR PEPTIDE SYNTHESIS

The invention discloses Fmoc protected (2S)-2-amino-8-[(1,1- dimethylethoxy)amino]-8-oxo-octanoic acid, (S)-2-amino-8- oxononanoic acid and (S)-2-amino-8-oxodecanoic acid for use in peptide synthesis, such as solid phase synthesis, as well as the peptide H3K27 (Ac-Lys-Ala-Ala-Arg-Aox-Ser-Ala-NH2) prepared from Fmoc protected (2S)-2-amino-8-[(1,1-dimethylethoxy)amino]-8-oxo-octanoic acid (Aox). These three exemplary compounds as well as their unprotected forms are claimed in the form of four generic formulae. The first of these four formulae is (formula (I)) where -NPro is a protected amino group, such as an amino group protected with a base-labile protecting group, -L- is alkylene, heteroalkylene, arylene or aralkylene, -X- is a covalent bond, -N(H) - or -N(RN)-, where -RN is alkyl, -R2 is hydrogen or alkyl, -R3 is alkyl, such as C2-10 alkyl, or heterocyclyl, and -LAA- and -R1 are as defined in the claims.