306960-29-2

Basic information

• Product Name: 3-Pyridinecarbonitrile,2-amino-1,4-dihydro-4-oxo-(9CI)
• Synonyms: 3-Pyridinecarbonitrile,2-amino-1,4-dihydro-4-oxo-(9CI);2-amino-3-cyano-1H-pyrid-4-one;2-amino-1,4-dihydro-4-oxo-3-Pyridinecarbonitrile
• CAS NO: 306960-29-2
• Molecular Formula: C6H5N3O
• Molecular Weight: 135.1234
• Product Categories: PYRIDINE
• Mol File: 306960-29-2.mol

Chemical Properties

• Boiling Point: 352.0±42.0 °C(Predicted)
• Appearance: /
• Density: 1.37±0.1 g/cm3(Predicted)
• PKA: 10.12±0.69(Predicted)
• CAS DataBase Reference: 3-Pyridinecarbonitrile,2-amino-1,4-dihydro-4-oxo-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Pyridinecarbonitrile,2-amino-1,4-dihydro-4-oxo-(9CI)(306960-29-2)
• EPA Substance Registry System: 3-Pyridinecarbonitrile,2-amino-1,4-dihydro-4-oxo-(9CI)(306960-29-2)

Safety Data

• Hazardous Substances Data: 306960-29-2(Hazardous Substances Data)

Upstream product

• 16029-98-4 trimethylsilyl iodide 
• 98651-70-8 2-amino-4-methoxypyridine-3-carbonitrile 
• 5417-82-3 (1-ethoxyethylidene)malononitrile 
• 98645-48-8 2-Amino-4-ethoxypyridin-3-carbonitril 

Downstream Products

• 852222-48-1 4-amino-8-(4-amino-phenyl)-8H-pyrido[2,3-d]pyrimidin-5-one 
• 306960-30-5 4-aminopyrido[2,3-d]pyrimidin-5(8H)-one 
• 306960-37-2 8-{3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-oxo-tetrahydro-furan-2-yl}-4-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-8H-pyrido[2,3-d]pyrimidin-5-one 
• 1053475-66-3 8-{3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl}-4-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-8H-pyrido[2,3-d]pyrimidin-5-one 
• 385435-85-8 C₄₁H₃₂N₄O₁₀ 
• 1053698-55-7 C₃₅H₂₆N₄O₈ 
• 1053257-01-4 C₃₆H₃₀N₄O₈ 
• 1054613-29-4 C₃₅H₃₀N₄O₈ 
• 1053255-08-5 C₃₅H₂₈N₄O₈ 

Relevant articles and documents

SULFONAMIDES

The invention relates to compounds of formula (I) in which R6, R7, R8, R9 and X have the meanings cited in Claim 1. These compounds are inhibitors of tyrosinkinases, particularly TIE-2, and Raf kinases and can, among other things, be used for treating tumors.

PYRIDOPYRIMIDINONES

The invention relates to compounds of formula (I) wherein R1, R2 , R3 , R4 , R5, R6 , R7 , R8, R9, X and X' have the designations cited in patent claim 1. Said compounds are inhibitors of tyrosine kinases, especially TIE-2, and Raf kinases, and can, inter alia, be used for the treatment of tumours.

Synthesis and cytotoxicity of 4-amino-5-oxopyrido[2,3-d]pyrimidine nucleosides

A number of nucleoside analogues have been either used clinically as anticancer drugs or evaluated in clinical studies, while new nucleoside analogues continue to show promise. In this article, we report synthesis and cytotoxicity of a series of new pyrid