307542-03-6Relevant articles and documents
Synthesis and in vitro evaluation of novel liver X receptor agonists based on naphthoquinone derivatives
Nishioka, Tatsuma,Endo-Umeda, Kaori,Ito, Yuki,Shimoda, Akane,Takeuchi, Atsuko,Tode, Chisato,Hirota, Yoshihisa,Osakabe, Naomi,Makishima, Makoto,Suhara, Yoshitomo
, (2019/12/04)
We aimed to synthesize novel liver X receptor (LXR) agonists with potent agonist activity and subtype selectivity. Our synthetic scheme started with naphthoquinone derivatives, such as menadione and 2,3-dichloro-1,4-naphthoquinone. We introduced different
INHIBITORS OF THE MITF MOLECULAR PATHWAY
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Paragraph 00273, (2015/01/09)
Provided herein are compounds of the formula (IV) as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful as MITF inhibitors, MITF pathway inhibitors and for the treatment of cancer.