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7-O-(3-BROMOPROPYL)-3-(4-HYDROXYPHENYL)-4H-1-BENZOPYRAN-4-ONE is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 309252-38-8 Structure
  • Basic information

    1. Product Name: 7-O-(3-BROMOPROPYL)-3-(4-HYDROXYPHENYL)-4H-1-BENZOPYRAN-4-ONE
    2. Synonyms: 7-O-W-BROMOPROPYLDAIDZEIN;7-O-(3-BROMOPROPYL)-3-(4-HYDROXYPHENYL)-4H-1-BENZOPYRAN-4-ONE;7-(3-bromopropoxy)-3-(4-hydroxyphenyl)-4H-chromen-4-one
    3. CAS NO:309252-38-8
    4. Molecular Formula: C18H15BrO4
    5. Molecular Weight: 375.21
    6. EINECS: N/A
    7. Product Categories: All Inhibitors;Inhibitors
    8. Mol File: 309252-38-8.mol
  • Chemical Properties

    1. Melting Point: 178-179°C
    2. Boiling Point: 556.5°C at 760 mmHg
    3. Flash Point: 290.3°C
    4. Appearance: /
    5. Density: 1.513g/cm3
    6. Vapor Pressure: 5.44E-13mmHg at 25°C
    7. Refractive Index: 1.644
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. CAS DataBase Reference: 7-O-(3-BROMOPROPYL)-3-(4-HYDROXYPHENYL)-4H-1-BENZOPYRAN-4-ONE(CAS DataBase Reference)
    11. NIST Chemistry Reference: 7-O-(3-BROMOPROPYL)-3-(4-HYDROXYPHENYL)-4H-1-BENZOPYRAN-4-ONE(309252-38-8)
    12. EPA Substance Registry System: 7-O-(3-BROMOPROPYL)-3-(4-HYDROXYPHENYL)-4H-1-BENZOPYRAN-4-ONE(309252-38-8)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 309252-38-8(Hazardous Substances Data)

309252-38-8 Usage

Chemical Properties

Crystalline Solid

Check Digit Verification of cas no

The CAS Registry Mumber 309252-38-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,0,9,2,5 and 2 respectively; the second part has 2 digits, 3 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 309252-38:
(8*3)+(7*0)+(6*9)+(5*2)+(4*5)+(3*2)+(2*3)+(1*8)=128
128 % 10 = 8
So 309252-38-8 is a valid CAS Registry Number.
InChI:InChI=1/C18H15BrO4/c19-8-1-9-22-14-6-7-15-17(10-14)23-11-16(18(15)21)12-2-4-13(20)5-3-12/h2-7,10-11,20H,1,8-9H2

309252-38-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name 7-(3-bromopropoxy)-3-(4-hydroxyphenyl)chromen-4-one

1.2 Other means of identification

Product number -
Other names 7-O-w-Bromopropyldaidzein

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:309252-38-8 SDS

309252-38-8Downstream Products

309252-38-8Relevant articles and documents

Isoflavoues aglycone derivative and preparation method and application of isoflavoues aglycone derivative

-

Paragraph 0057; 0058; 0059; 0060; 0061, (2018/07/30)

The invention provides an isoflavoues aglycone derivative shown as in the formula (I) (as described in the description), wherein R is a nitrogen-containing heterocyclic ring group or a substituted nitrogen-containing heterocyclic ring group; a substituent group in the substituted nitrogen-containing heterocyclic ring group is chosen from C1-C10 alkyl groups, and n is an integer more than or equalto 1. Compared with the prior art, the provided isoflavoues aglycone derivative has an excellent effect on inhibiting the growth of multiple tumor cells, and particularly when n is equal to 3, the isoflavoues aglycone derivative has a higher activity on inhibiting the growth of three tumor cells of a cell A549, a cell Hela and HepG2.

The mitochondrial monoamine oxidase - Aldehyde dehydrogenase pathway: A potential site of action of daidzin

Rooke,Li,Li,Keung

, p. 4169 - 4179 (2007/10/03)

Recent studies showed that daidzin suppresses ethanol intake in ethanol-preferring laboratory animals. In vitro, it potently and selectively inhibits the mitochondrial aldehyde dehydrogenase (ALDH-2). Further, it inhibits the conversion of monoamines such as serotonin (5-HT) and dopamine (DA) into their respective acid metabolites, 5-hydroxyindole-3-acetic acid (5-HIAA) and 3,4-dihydroxyphenylacetic acid (DOPAC) in isolated hamster or rat liver mitochondria. Studies on the suppression of ethanol intake and inhibition of 5-HIAA (or DOPAC) formation by six structural analogues of daidzin suggested a potential link between these two activities. This, together with the finding that daidzin does not affect the rates of mitochondria-catalyzed oxidative deamination of these monoamines, raised the possibility that the ethanol intake-suppressive (antidipsotropic) action of daidzin is not mediated by the monoamines but rather by their reactive biogenic aldehyde intermediates such as 5-hydroxyindole-3-acetaldehyde (5-HIAL) and/or 3,4-dihydroxyphenylacetaldehyde (DOPAL) which accumulate in the presence of daidzin. To further evaluate this possibility, we synthesized more structural analogues of daidzin and tested and compared their antidipsotropic activities in Syrian golden hamsters with their effects on monoamine metabolism in isolated hamster liver mitochondria using 5-HT as the substrate. Effects of daidzin and its structural analogues on the activities of monoamine oxidase (MAO) and ALDH-2, the key enzymes involved in 5-HT metabolism in the mitochondria, were also examined. Results from these studies reveal a positive correlation between the antidipsotropic activities of these analogues and their abilities to increase 5-HIAL accumulation during 5-HT metabolism in isolated hamster liver mitochondria. Daidzin analogues that potently inhibit ALDH-2 but have no or little effect on MAO are most antidipsotropic, whereas those that also potently inhibit MAO exhibit little, if any, antidipsotropic activity. These results, although inconclusive, are consistent with the hypothesis that daidzin may act via the mitochondrial MAO/ALDH pathway and that a biogenic aldehyde such as 5-HIAL may be important in mediating its antidipsotropic action.

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