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486-66-8

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Daidzein
Cas No: 486-66-8
No Data No Data Metric Ton/Day shanghai Tauto Biotech Co., Ltd Contact Supplier
Soya Isoflavones
Cas No: 486-66-8
USD $ 40.0-40.0 / Kilogram 1 Kilogram 300 Kilogram/Month Greenutra Resource Inc Contact Supplier
Daidzein
Cas No: 486-66-8
USD $ 3.0-3.0 / Kilogram 1 Kilogram 1-100 Metric Ton/Month Dayang Chem (Hangzhou) Co.,Ltd. Contact Supplier
High purity Various Specifications Daidzein CAS:486-66-8
Cas No: 486-66-8
USD $ 100.0-500.0 / Gram 1 Gram 99999 Gram/Year Hangzhou Dingyan Chem Co., Ltd Contact Supplier
High quality Daidzein supplier in China
Cas No: 486-66-8
No Data 1 Metric Ton 30 Metric Ton/Month Simagchem Corporation Contact Supplier
Daidzein
Cas No: 486-66-8
USD $ 800.0-1000.0 / Kilogram 1 Kilogram 5000 Kilogram/Day Kono Chem Co.,Ltd Contact Supplier
Daidzein CAS NO.486-66-8
Cas No: 486-66-8
USD $ 2.0-2.0 / Gram 100 Gram 100 Metric Ton/Month Hebei yanxi chemical co.,LTD. Contact Supplier
Health Supplement Daidzein Powder 99% HPLC
Cas No: 486-66-8
USD $ 1.8-2.3 / Gram 500 Gram 100000 Kilogram/Year Xi'an Quanao Biotech Co., Ltd. Contact Supplier
Daidzein
Cas No: 486-66-8
No Data No Data No Data Chemwill Asia Co., Ltd. Contact Supplier
High Quality 99% Daidzein 486-66-8 GMP manufacturer
Cas No: 486-66-8
USD $ 0.1-0.1 / Gram 1 Gram 100 Metric Ton/Year Xi'an Xszo Chem Co., Ltd. Contact Supplier

486-66-8 Usage

Uses

phytoestrogen

Biological Activity

Analog of the phytoestrogen genistein (5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one ). Blocks G 1 phase cell cycle progression and is an agonist at estrogen receptors.

Uses

Inactive analog of Genistein (Cat. #G350000). Blocks the G1 phase of the cell cycle in Swiss 3T3 cells by inhibiting casein kinase II activity1. Daidzein has also been shown to inhibit the action of GABA on recombinant GABAA receptors2. uv max:250 nm (log e 4.44)

Definition

ChEBI: A member of the class of 7-hydroxyisoflavones that is 7-hydroxyisoflavone substituted by an additional hydroxy group at position 4'.

Uses

Daidzein belongs to the group of isoflavones. Daidzein and other isoflavone compounds, such as genistein, are present in a number of plants and herbs. Soy isoflavones are a group of compounds found in and isolated from the soybean. Besides functioning as

Chemical Properties

Off-White Crystalline Solid
InChI:InChI=1/C15H10O4/c16-10-6-4-9(5-7-10)11-8-19-13-3-1-2-12(17)14(13)15(11)18/h1-8,16-17H

486-66-8 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
TCI America (D2668)  Daidzein  >98.0%(HPLC)(T) 486-66-8 1g 253.00CNY Detail
Alfa Aesar (B22877)  4',7-Dihydroxyisoflavone, 97%    486-66-8 1g 719.0CNY Detail
Alfa Aesar (B22877)  4',7-Dihydroxyisoflavone, 97%    486-66-8 5g 1593.0CNY Detail
Alfa Aesar (B22877)  4',7-Dihydroxyisoflavone, 97%    486-66-8 25g 5927.0CNY Detail
USP (1162421)  Daidzein  United States Pharmacopeia (USP) Reference Standard 486-66-8 1162421-25MG 4,662.45CNY Detail
Sigma-Aldrich (16587)  Daidzein  analytical standard 486-66-8 16587-10MG 2,046.33CNY Detail
Sigma-Aldrich (05340590)  Daidzein  primary pharmaceutical reference standard 486-66-8 05340590-50MG 5,933.07CNY Detail

486-66-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name Daidzein

1.2 Other means of identification

Product number -
Other names 4H-1-Benzopyran-4-one, 7-hydroxy-3-(4-hydroxyphenyl)-

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:486-66-8 SDS

486-66-8Synthetic route

daidzin
552-66-9

daidzin

daidzein
486-66-8

daidzein

Conditions
ConditionsYield
β-glucosidase, derived from Aspergillus niger In methanol at 55℃; for 6h; pH=4; Enzyme kinetics; Aqueous acetate buffer;100%
diglycosidase, produced by Penicillium multicolor IAM7153 In methanol at 55℃; for 6h; pH=4; Enzyme kinetics; Aqueous acetate buffer;88.5%
With sulfonated graphene oxide nanosheets In water; ethylene glycol at 105℃; for 8h; Reagent/catalyst; Sealed tube;55.7%
2,4,4'-trihydroxy deoxybenzoin
17720-60-4

2,4,4'-trihydroxy deoxybenzoin

daidzein
486-66-8

daidzein

Conditions
ConditionsYield
With methanesulfonyl chloride In N,N-dimethyl-formamide at 60 - 70℃; for 1.5h;98%
Multi-step reaction with 2 steps
1: pyridine / Behandeln des Reaktionsprodukts mit wss. Natronlauge
2: 300 °C
View Scheme
daidzein 7-O-phosphate

daidzein 7-O-phosphate

daidzein
486-66-8

daidzein

Conditions
ConditionsYield
With sulfatase VIII In water at 37℃; for 0.5h; pH=5.2;98%
6''-O-Acetyldaidzin

6''-O-Acetyldaidzin

daidzein
486-66-8

daidzein

Conditions
ConditionsYield
diglycosidase, produced by Penicillium multicolor IAM7153 In methanol at 55℃; for 6h; pH=4; Enzyme kinetics; Aqueous acetate buffer;96.2%
diglycosidase, produced by Aspergillus fumigatus IAM2046 In methanol at 55℃; for 6h; pH=4; Enzyme kinetics; Aqueous acetate buffer;66.5%
β-glucosidase, derived from Aspergillus niger In methanol at 55℃; for 6h; pH=4; Enzyme kinetics; Aqueous acetate buffer;9%
β-xylosidase, derived from pectinase G In methanol at 55℃; for 1h; pH=4; Enzyme kinetics; Aqueous acetate buffer;9.7%
β-glucosidase, derived from almond In methanol at 55℃; for 6h; pH=4; Enzyme kinetics; Aqueous acetate buffer;0.6%
7-methoxy-3-(4-methoxyphenyl)-4H-chromen-4-one
1157-39-7

7-methoxy-3-(4-methoxyphenyl)-4H-chromen-4-one

daidzein
486-66-8

daidzein

Conditions
ConditionsYield
With hydrogen iodide for 4h; Reflux;94%
With aluminum (III) chloride In toluene at 100℃; for 12h; Sealed tube; Inert atmosphere;92%
With boron tribromide84%
With pyridine hydrochloride at 180℃; for 12h; Inert atmosphere;63%
With hydrogen iodide
7-benzyloxy-3-(4-methoxyphenyl)-1-benzopyran-4-one
1621-59-6

7-benzyloxy-3-(4-methoxyphenyl)-1-benzopyran-4-one

daidzein
486-66-8

daidzein

Conditions
ConditionsYield
With aluminum (III) chloride; ethanethiol In dichloromethane at 0℃; for 0.5h; Inert atmosphere;92%
With aluminum (III) chloride; ethanethiol In dichloromethane at 0℃; for 0.5h; Inert atmosphere;92%
7-Hydroxy-3-(4-methoxy-phenyl)-chromen-4-on
485-72-3

7-Hydroxy-3-(4-methoxy-phenyl)-chromen-4-on

daidzein
486-66-8

daidzein

Conditions
ConditionsYield
Stage #1: 7-Hydroxy-3-(4-methoxy-phenyl)-chromen-4-on With boron tribromide In dichloromethane at 0 - 20℃; for 4h;
Stage #2: With water In dichloromethane at 0℃;
65%
With boron tribromide In dichloromethane at 0 - 20℃;65%
6''-O-malonyldaidzin
124590-31-4

6''-O-malonyldaidzin

daidzein
486-66-8

daidzein

Conditions
ConditionsYield
diglycosidase, produced by Penicillium multicolor IAM7153 In methanol at 55℃; for 6h; pH=4; Enzyme kinetics; Aqueous acetate buffer;61.5%
diglycosidase, produced by Aspergillus fumigatus IAM2046 In methanol at 55℃; for 6h; pH=4; Enzyme kinetics; Aqueous acetate buffer;32.3%
β-glucosidase, derived from Aspergillus niger In methanol at 55℃; for 6h; pH=4; Enzyme kinetics; Aqueous acetate buffer;16%
β-xylosidase, derived from pectinase G In methanol at 55℃; for 6h; pH=4; Enzyme kinetics; Aqueous acetate buffer;3.3%
4-hydroxyphenylacetate
156-38-7

4-hydroxyphenylacetate

recorcinol
108-46-3

recorcinol

daidzein
486-66-8

daidzein

Conditions
ConditionsYield
Stage #1: 4-hydroxyphenylacetate; recorcinol With zinc(II) chloride at 140℃; under 600.06 Torr; for 0.333333h;
Stage #2: With moroxydine; acetic acid; orthoformic acid triethyl ester In N,N-dimethyl-formamide at 140℃; for 5h; Temperature;
60%
methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

recorcinol
108-46-3

recorcinol

2-Hydroxyphenylacetic acid
614-75-5

2-Hydroxyphenylacetic acid

daidzein
486-66-8

daidzein

Conditions
ConditionsYield
In ethanol; water; trifluoroborane diethyl ether; N,N-dimethyl-formamide44%
7-hydroxy-3-(4-aminophenyl)-4H-benzopyran-4-one
77316-78-0

7-hydroxy-3-(4-aminophenyl)-4H-benzopyran-4-one

daidzein
486-66-8

daidzein

Conditions
ConditionsYield
With sulfuric acid; sodium nitrite ueber das Diazoniumsalz;
pratol
487-24-1

pratol

daidzein
486-66-8

daidzein

Conditions
ConditionsYield
With hydrogen iodide
2-Carboxy-7,4'-dihydroxyisoflavone
57023-42-4

2-Carboxy-7,4'-dihydroxyisoflavone

daidzein
486-66-8

daidzein

Conditions
ConditionsYield
at 300℃;
7,4'-dihydroxy-dihydroflavone
69097-97-8

7,4'-dihydroxy-dihydroflavone

A

daidzein
486-66-8

daidzein

B

(2R,3S)-2,7,4'-trihydroxyisoflavanone
131887-80-4

(2R,3S)-2,7,4'-trihydroxyisoflavanone

Conditions
ConditionsYield
With NADPH at 30℃; for 0.75h; Mechanism; cytochrome P-450; other substrates, effect of detergents;
1-(2,4-Dihydroxy-phenyl)-2-(4-hydroxy-phenyl)-3,3-dimethoxy-propan-1-one

1-(2,4-Dihydroxy-phenyl)-2-(4-hydroxy-phenyl)-3,3-dimethoxy-propan-1-one

daidzein
486-66-8

daidzein

Conditions
ConditionsYield
With hydrogenchloride In methanol for 2h; Heating; Yield given;
Formic acid 3-(4-hydroxy-phenyl)-4-oxo-4H-chromen-7-yl ester

Formic acid 3-(4-hydroxy-phenyl)-4-oxo-4H-chromen-7-yl ester

daidzein
486-66-8

daidzein

Conditions
ConditionsYield
With triethylamine; formyl acetic anhydride at 80 - 100℃; for 0.25h; Yield given;
daidzin
552-66-9

daidzin

A

D-Glucose
2280-44-6

D-Glucose

B

daidzein
486-66-8

daidzein

Conditions
ConditionsYield
With hydrogenchloride
With citrate buffer; phosphate buffer; soybean β-glucosidase at 40℃; pH=5.0; Enzyme kinetics;
2,7,4'-trihydroxyisoflavanone
109963-62-4

2,7,4'-trihydroxyisoflavanone

daidzein
486-66-8

daidzein

Conditions
ConditionsYield
2-hydroxyisoflavanone dehydratase In phosphate buffer; acetone at 30℃; for 0.333333h; pH=7.0; Dehydration;
2-hydroxyisoflavanone dehydratase In phosphate buffer; acetone at 30℃; for 0.333333h; pH=7.0; Enzyme kinetics; Dehydration;
2,4,4'-trihydroxy deoxybenzoin
17720-60-4

2,4,4'-trihydroxy deoxybenzoin

zinc cyanide

zinc cyanide

daidzein
486-66-8

daidzein

Conditions
ConditionsYield
With diethyl ether Einleiten von Chlorwasserstoff und Erhitzen des Reaktionsprodukts mit Wasser;
Multi-step reaction with 2 steps
1: Et3N / 0.17 h / 0 °C
2: mixed anhydride of acetic and formic acid, Et3N / 0.25 h / 80 - 100 °C
View Scheme
2,4,4'-trihydroxy deoxybenzoin
17720-60-4

2,4,4'-trihydroxy deoxybenzoin

formic acid ethyl ester
109-94-4

formic acid ethyl ester

sodium

sodium

daidzein
486-66-8

daidzein

Conditions
ConditionsYield
Erhitzen des Reaktionsprodukts mit wss.-aethanol.HCl;
daidzein
486-66-8

daidzein

equol
531-95-3

equol

Conditions
ConditionsYield
With Eggerthella sp. YY7918 at 37℃; for 72h;100%
With 5%-palladium/activated carbon; hydrogen; acetic acid In ethanol; water at 20℃; under 760.051 Torr; for 10h;95%
daidzein
486-66-8

daidzein

3',4',7-trihydroxyisoflavone
485-63-2

3',4',7-trihydroxyisoflavone

Conditions
ConditionsYield
With bacillus megaterium tyrosinase In dimethyl sulfoxide at 20℃; for 6h; pH=9 - 10; Enzymatic reaction;100%
With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione In dimethyl sulfoxide at 50℃; for 2h;28%
With ferredoxin reductase; ferredoxin; recombinant CYP105D7 from Streptomyces avermitilis MA4680; NADH In aq. phosphate buffer at 20℃; for 2h; pH=7.2; Kinetics; Enzymatic reaction;
Multi-step reaction with 4 steps
1: potassium carbonate / acetone / 12 h / 60 °C
2: bromine / dichloromethane / 0.5 h / 20 °C
3: copper(I) bromide / methanol; N,N-dimethyl-formamide / 2 h / 20 - 120 °C / Darkness
4: dimethylsulfide; aluminum (III) chloride / dichloromethane / 6 h / 5 - 20 °C
View Scheme
daidzein
486-66-8

daidzein

3-(chloromethyl)-2-benzothiazolinone
73762-91-1

3-(chloromethyl)-2-benzothiazolinone

daidzein 7-N-(2
640275-93-0

daidzein 7-N-(2"(3"H)-benzothiazolonyl)methyl ether

Conditions
ConditionsYield
With potassium carbonate In DMF (N,N-dimethyl-formamide) at 80℃; for 14h;98.4%
daidzein
486-66-8

daidzein

acetic anhydride
108-24-7

acetic anhydride

daidzein diacetate
3682-01-7

daidzein diacetate

Conditions
ConditionsYield
Stage #1: daidzein; acetic anhydride at 60℃; for 0.166667h;
Stage #2: With pyridine at 60℃; for 0.0833333h;
98%
for 3h; Reflux;96.5%
With pyridine at 105 - 110℃; for 1h;90%
daidzein
486-66-8

daidzein

Hexanoyl chloride
142-61-0

Hexanoyl chloride

7,4'-di-O-hexanoyl-daidzein
602329-45-3

7,4'-di-O-hexanoyl-daidzein

Conditions
ConditionsYield
With dmap; triethylamine In N,N-dimethyl-formamide at 20℃; for 4.5h; Cooling with ice;95%
With pyridine; dmap In chloroform at -20℃;77%
daidzein
486-66-8

daidzein

allyl bromide
106-95-6

allyl bromide

7-allyloxy-3-(4-allyloxy-phenyl)-4H-chromen-4-one
102042-06-8

7-allyloxy-3-(4-allyloxy-phenyl)-4H-chromen-4-one

Conditions
ConditionsYield
With potassium carbonate In acetone for 8h; Williamson-type O-alkylation reaction; Reflux;94%
daidzein
486-66-8

daidzein

7,4’-dihydroxy-3’-nitroisoflavone

7,4’-dihydroxy-3’-nitroisoflavone

Conditions
ConditionsYield
With ammonium nitrate; trifluoroacetic anhydride In acetonitrile at 20℃; for 1.5h;94%
With ammonium cerium (IV) nitrate; acetic acid In N,N-dimethyl-formamide at 20℃;92%
With sulfuric acid; nitric acid In ethanol at 20℃; for 2h;
daidzein
486-66-8

daidzein

(+/-)-4-Hydroxy-Equol

(+/-)-4-Hydroxy-Equol

Conditions
ConditionsYield
With 5%-palladium/activated carbon; hydrogen In N,N-dimethyl-formamide at 25℃; under 600.06 Torr; for 3h; Time;93%
With hydrogen; 10% Pd/Al2O3 In ethanol under 750.075 Torr;
Multi-step reaction with 3 steps
1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 40 °C
2: sodium tetrahydroborate; ethanol / tetrahydrofuran / 0 - 20 °C / Inert atmosphere
3: palladium(II) hydroxide; ammonium formate / water; tetrahydrofuran; ethanol / Inert atmosphere
View Scheme
daidzein
486-66-8

daidzein

N-chloroethylpiperidine hydrochloride
2008-75-5

N-chloroethylpiperidine hydrochloride

7-(2-(piperidin-1-yl)ethoxy)-3-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-4H-chromen-4-one
41524-24-7

7-(2-(piperidin-1-yl)ethoxy)-3-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-4H-chromen-4-one

Conditions
ConditionsYield
With potassium carbonate In acetone for 8h; Williamson-type O-alkylation reaction; Reflux;93%
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