309947-88-4Relevant articles and documents
LIPID COMPOUNDS AND LIPID NANOPARTICLE COMPOSITIONS
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Paragraph 00343, (2022/03/02)
Provided herein are lipid compounds that can be used in combination with other lipid components, such as neutral lipids, cholesterol and polymer conjugated lipids, to form lipid nanoparticles for delivery of therapeutic agents (e.g., nucleic acid molecules) for therapeutic or prophylactic purposes, including vaccination. Also provided herein are lipid nanoparticle compositions comprising said lipid compounds.
Selection of new sequence-selective unnatural peptides binding to double-stranded deoxyribonucleic acids (dsDNA) by means of a gel-retardation experiment for library analysis
Chaltin, Patrick,Lescrinier, Eveline,Lescrinier, Theo,Rozenski, Jef,Hendrix, Chris,Rosemeyer, Helmut,Busson, Roger,Van Aerschot, Arthur,Herdewijn, Piet
, p. 2258 - 2283 (2007/10/03)
Previously, we developed a methodology for the solid-phase screening of peptide libraries for interaction with double-stranded deoxyribonucleic acids (dsDNA). In the search for new and more-potent DNA ligands, we investigated the strategy of solution-phas
Synthesis of nucleic-acid base containing norbornene derivatives as monomers for ring-opening-metathesis-polymerization
Davies, R. Gareth,Gibson, Vernon C.,Hursthouse, Michael B.,Light, Mark E.,Marshall, Edward L.,North, Michael,Robson, David A.,Thompson, Ian,White, Andrew J. P.,Williams, David J.,Williams, Paul J.
, p. 3365 - 3381 (2007/10/03)
A series of norbornene derivatives containing nucleic-acid bases (thymine, adenine, cytosine, guanine, or uracil) have been prepared as monomers for ring-opening-metathesis-polymerization (ROMP). Many of the initially prepared monomers had poor solubility but this could be overcome by appropriate choice of a linker between the norbornene and base units. Some of the monomers were successfully polymerised to give homopolymers derived from nucleic-acid base.
