31186-12-6Relevant articles and documents
Total synthesis of altenusin and alterlactone
Cudaj, Judith,Podlech, Joachim
, p. 371 - 374 (2012/03/27)
The resorcylic lactone alterlactone, a mycotoxin produced by alternaria sp., was synthesized for the first time. The total synthesis was achieved in nine steps with 69% yield starting with acetal-protected phloroglucinic acid and 6-bromopiperonal, where t
Synthesis and structure-activity relationships of dehydroaltenusin derivatives as selective DNA polymerase α inhibitors
Kuramochi, Kouji,Fukudome, Keishi,Kuriyama, Isoko,Takeuchi, Toshifumi,Sato, Yoshihiro,Kamisuki, Shinji,Tsubaki, Kazunori,Sugawara, Fumio,Yoshida, Hiromi,Mizushina, Yoshiyuki
experimental part, p. 7227 - 7238 (2010/03/03)
Herein, we describe the synthesis and structure-activity relationships of dehydroaltenusin derivatives as inhibitors of a mammalian DNA polymerase α. We have newly synthesized nine dehydroaltenusin derivatives modified at the side chains or benzoquinone m
Total synthesis of dehydroaltenusin
Kamisuki, Shinji,Takahashi, Shunya,Mizushina, Yoshiyuki,Hanashima, Shinya,Kuramochi, Kouji,Kobayashi, Susumu,Sakaguchi, Kengo,Nakata, Tadashi,Sugawara, Fumio
, p. 5695 - 5700 (2007/10/03)
The first total synthesis of dehydroaltenusin, a natural enzyme inhibitor, is described. The key step involves Suzuki-coupling reaction of an aryl triflate prepared from 2,4,6-trihydroxybenzoic acid with a catechol-derived boronic acid or boronic ester. T
Total synthesis of dehydroaltenusin
Takahashi, Shunya,Kamisuki, Shinji,Mizushina, Yoshiyuki,Sakaguchi, Kengo,Sugawara, Fumio,Nakata, Tadashi
, p. 1875 - 1877 (2007/10/03)
First total synthesis of dehydroaltenusin, a natural enzyme inhibitor, is described. The key step involves Suzuki-couplig reaction of aryl triflate prepared from 2,4,6-trihydroxy benzoic acid with a catechol-derived boronic acid. The synthetic sample was
