312949-34-1

Basic information

• Product Name: 2-AMINO-N-(3-CHLOROPHENYL)-5,6,7,8-TETRAHYDRO-4H-CYCLOHEPTA[B]THIOPHENE-3-CARBOXAMIDE
• Synonyms: TIMTEC-BB SBB001317;ART-CHEM-BB B014607;2-AMINO-N-(3-CHLOROPHENYL)-5,6,7,8-TETRAHYDRO-4H-CYCLOHEPTA[B]THIOPHENE-3-CARBOXAMIDE
• CAS NO: 312949-34-1
• Molecular Formula: C16H17ClN2OS
• Molecular Weight: 320.84
• Mol File: 312949-34-1.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-AMINO-N-(3-CHLOROPHENYL)-5,6,7,8-TETRAHYDRO-4H-CYCLOHEPTA[B]THIOPHENE-3-CARBOXAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-N-(3-CHLOROPHENYL)-5,6,7,8-TETRAHYDRO-4H-CYCLOHEPTA[B]THIOPHENE-3-CARBOXAMIDE(312949-34-1)
• EPA Substance Registry System: 2-AMINO-N-(3-CHLOROPHENYL)-5,6,7,8-TETRAHYDRO-4H-CYCLOHEPTA[B]THIOPHENE-3-CARBOXAMIDE(312949-34-1)

Safety Data

• Hazardous Substances Data: 312949-34-1(Hazardous Substances Data)

Usage

Also known as

TAK-632

Potential pharmacological applications

It is an inhibitor of the mitogen-activated protein kinase (MAPK) pathway

Role in cell growth

It plays a crucial role in cell growth, proliferation, and survival

Potential use in cancer treatment

Particularly in targeting tumors with specific genetic mutations

Anticancer activity

Research has shown that TAK-632 exhibits potent anticancer activity in preclinical studies

Promise for further drug development

Making it a promising candidate for further drug development in the field of oncology

Need for further research and clinical trials

To fully understand its therapeutic potential and safety profile

Upstream product

• 17722-12-2 N-(3-chlorophenyl)-2-cyanoacetamide 
• 329067-38-1 C₁₆H₁₇ClN₂O 
• 108-42-9 3-chloro-aniline 

Relevant articles and documents

Optimization of 2-acylaminocycloalkylthiophene derivatives for activity against Staphylococcus aureus RnpA

Staphylococcus aureus is well-recognized to cause debilitating bacterial infections that are difficult to treat due to the emergence of antibiotic resistance. As such, there is a need to develop new antimicrobials for the therapeutic intervention of S. au

Substituted 2-Acylaminocycloalkylthiophene-3-carboxylic Acid Arylamides as Inhibitors of the Calcium-Activated Chloride Channel Transmembrane Protein 16A (TMEM16A)

Transmembrane protein 16A (TMEM16A), also called anoctamin 1 (ANO1), is a calcium-activated chloride channel expressed widely mammalian cells, including epithelia, vascular smooth muscle tissue, electrically excitable cells, and some tumors. TMEM16A inhibitors have been proposed for treatment of disorders of epithelial fluid and mucus secretion, hypertension, asthma, and possibly cancer. Herein we report, by screening, the discovery of 2-acylaminocycloalkylthiophene-3-carboxylic acid arylamides (AACTs) as inhibitors of TMEM16A and analysis of 48 synthesized analogs (10ab-10bw) of the original AACT compound (10aa). Structure-activity studies indicated the importance of benzene substituted as 2- or 4-methyl, or 4-fluoro, and defined the significance of thiophene substituents and size of the cycloalkylthiophene core. The most potent compound (10bm), which contains an unusual bromodifluoroacetamide at the thiophene 2-position, had IC50 of ～30 nM, ～3.6-fold more potent than the most potent previously reported TMEM16A inhibitor 4 (Ani9), and >10-fold improved metabolic stability. Direct and reversible inhibition of TMEM16A by 10bm was demonstrated by patch-clamp analysis. AACTs may be useful as pharmacological tools to study TMEM16A function and as potential drug development candidates.