313537-28-9

Basic information

• Product Name: 4-ethyl-N-(3-methylphenyl)benzamide
• Synonyms: 4-ethyl-N-(3-methylphenyl)benzamide
• CAS NO: 313537-28-9
• Molecular Formula: C₁₆H₁₇NO
• Molecular Weight: 239.31228
• Mol File: 313537-28-9.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-ethyl-N-(3-methylphenyl)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-ethyl-N-(3-methylphenyl)benzamide(313537-28-9)
• EPA Substance Registry System: 4-ethyl-N-(3-methylphenyl)benzamide(313537-28-9)

Safety Data

• Hazardous Substances Data: 313537-28-9(Hazardous Substances Data)

Upstream product

• 201230-82-2 carbon monoxide 
• 63139-21-9 4-ethylphenylboronic acid 
• 108-44-1 1-amino-3-methylbenzene 
• 536-89-0 m-tolylhydrazine 
• 16331-45-6 p-ethylbenzoyl chloride 

Relevant articles and documents

Synthesis of Secondary Amides through the Palladium(II)-Catalyzed Aminocarbonylation of Arylboronic Acids with Amines or Hydrazines and Carbon Dioxide

A new Pd-catalyzed aminocarbonylation of arylboronic acids with amines or phenylhydrazines has been developed. Various secondary amides were produced from readily available substrates and cheap common metal catalysts in a CO atmosphere (balloon). Remarkably, we presents the first example of aminocarbonylations between arylboronic acids and phenylhydrazines.

Method for synthesizing N-aryl aromatic amide by adopting aromatic hydrazine

The invention discloses a method for synthesizing N-aryl aromatic amide by adopting aromatic hydrazine. The method includes that arylboronic acid, the aromatic hydrazine, a primary catalyst and an auxiliary catalyst are added in a solvent, the N-aryl aromatic amide as is indicated in the formula III is obtained by performing separation and purification after heating reflux reaction, and CO is fedto a reaction to enable pressure of the reaction system to be 0.1-5MPa during reaction. The method is concise and efficient, phenylhydrazine is substituted, organic boronic acid and CO which are stable in air and easy to obtain are taken as raw materials, metal palladium is taken as the primary catalyst, copper or iron is taken as the auxiliary catalyst, and the N-aryl aromatic amide is synthesized efficiently under mild reaction conditions.

NOVEL BIARYLAMIDE DERIVATIVE AND COMPOSITIONS CONTAINING THE DERIVATIVE AS AN ACTIVE INGREDIENT

The present invention relates to a novel biarylamide derivative and a pharmaceutical composition or a cosmetic composition comprising the same as an active ingredient. More particularly, the present invention relates to a novel biarylamide derivative, a pharmaceutical composition or a cosmetic composition for preventing or treating a pigmentation disorder caused by an abnormal excess of melanin or a disease caused by melanocyte hyperplasia comprising the same as an active ingredient. The biarylamide derivative of the present invention inhibits melanin production and thus inhibits melanocyte hyperplasia. Therefore, a cosmetic composition comprising the biarylamide is excellent in a whitening effect, and a pharmaceutical composition comprising the biarylamide is effective in the prevention or treatment of pigmentation disorders of skin such as lentigo, melasma, freckle, etc. and malignant melanoma.

Identification of a potent and noncytotoxic inhibitor of melanin production

On the basis of a hit from random screening, biaryl amide derivatives were prepared in a combinatorial manner via parallel solution-phase synthesis, and their effects on melanocytes were investigated to discover new effective skin depigmenting agents. Amo