314279-29-3

Basic information

• Product Name: 1H-indole-2,3-dione 3-[N-(3-methylphenyl)thiosemicarbazone]
• Synonyms: 1H-indole-2,3-dione 3-[N-(3-methylphenyl)thiosemicarbazone];(2E)-N-(3-methylphenyl)-2-(2-oxo-1,2-dihydro-3H-indol-3-ylidene)hydrazinecarbothioamide
• CAS NO: 314279-29-3
• Molecular Formula: C₁₆H₁₄N₄OS
• Molecular Weight: 310.37356
• Mol File: 314279-29-3.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1H-indole-2,3-dione 3-[N-(3-methylphenyl)thiosemicarbazone](CAS DataBase Reference)
• NIST Chemistry Reference: 1H-indole-2,3-dione 3-[N-(3-methylphenyl)thiosemicarbazone](314279-29-3)
• EPA Substance Registry System: 1H-indole-2,3-dione 3-[N-(3-methylphenyl)thiosemicarbazone](314279-29-3)

Safety Data

• Hazardous Substances Data: 314279-29-3(Hazardous Substances Data)

Upstream product

• 91-56-5 indole-2,3-dione 
• 40207-01-0 4-(3-methylphenyl)thiosemicarbazide 
• 108-44-1 1-amino-3-methylbenzene 
• 621-30-7 3-methylphenyl isothiocyanate 

Relevant articles and documents

Isatin-β-thiosemicarbazones as potent herpes simplex virus inhibitors

A series of isatin-β-thiosemicarbazones have been designed and evaluated for antiviral activity against herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) in a plaque reduction assay. Their cytotoxicity was examined using human rhabdomyosarcoma cells (RD cells). Several derivatives of isatin-β-thiosemicarbazone exhibited significant and selective antiviral activity with low cytotoxicity. It was found that the thiourea group at thiosemicarbazone and the NH functionality at isatin were essential for their antiherpetic activity. The synthesis and structure-activity relationship studies are presented.