cas 31431-17-1, 4,4'-DICHLORO-3-NITROBENZOPHENONE | Articles data ｜lookchem

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31431-17-1

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6-ALKENYL AND 6-PHENYLALKYL SUBSTITUTED 2-QUINOLINONES AND 2-QUINOXALINONES AS POLY(ADP-RIBOSE) POLYMERASE INHIBITORS
The present invention provides compounds of formula (I) and compounds of formula (I), (VII-a), as well as pharmaceutical compositions comprising said compounds and their use as PARP inhibitors wherein n, R1, R2, R3, R4, R5, R6, R7, Re, Rd and X have defined meanings.
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Page/Page column 49

(2010/02/12)

An improved procedure for the regiospecific synthesis of electron deficient 4- and 6-substituted isatins
The regiospecific synthesis of 4- and 6-substituted isatins 5a-g in four steps from halonitrobenzenes 1a-g has been investigated for a variety of substrates (Scheme 1). The procedure makes use of readily available, easily handled materials and in most cases purification of neither intermediates nor final products is required. Yields of isatins are between 26 and 75% (Table 1). Improved yields of known isatins are reported as well as the syntheses of previously unreported isatins. This method, taken together with known procedures, provides for the synthesis of the full complement of isatin regioisomers.
Kraynack, Erica A.,Dalgard, Jackline E.,Gaeta, Federico C. A.
p. 7679 - 7682
(2007/10/03)

Synthesis and anthelminthic acitivity of alkyl-(5-acyl-1-benzimidazol-2-yl) carbamates
A series of alkyl-(5-acyl-l-H-benzimidazol-2-yl)-carbamates were prepared and screened for anthelminthic activity. Some of them were found to be fully active at low, atoxic oral dose levels against gastro-intestinal nematodes. The activity against Syphacia muris and Strongyloides ratta is indicated. From these studies methyl (5-benzoyl-1-H-benzimidazol-2-yl) carbamate (mebendazole) and methyl [5-(4-fluorobenzoyl)-1-H-benzimidazol-2-yl]carbamate (flubendazole) were selected for detailed investigation.
Raeymackers,Van Gelder,Roevens,Janssen
p. 586 - 594
(2007/10/05)

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Chemical Properties

Melting Point: 86-90 °C(lit.)
Boiling Point: 446.9°C at 760 mmHg
Flash Point:224.1°C
Density: 1.456g/cm³
Vapor Pressure: 3.52E-08mmHg at 25°C
Refractive Index: 1.63
PSA: 62.89000
LogP: 4.65580

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