314768-98-4

Basic information

• Product Name: 2-AMINO-5-(4-METHYLPIPERIDINYL)BENZAMIDE
• Synonyms: 2-AMINO-5-(4-METHYLPIPERIDINYL)BENZAMIDE
• CAS NO: 314768-98-4
• Molecular Formula: C₁₃H₁₉N₃O
• Molecular Weight: 233.313
• Mol File: 314768-98-4.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-AMINO-5-(4-METHYLPIPERIDINYL)BENZAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-5-(4-METHYLPIPERIDINYL)BENZAMIDE(314768-98-4)
• EPA Substance Registry System: 2-AMINO-5-(4-METHYLPIPERIDINYL)BENZAMIDE(314768-98-4)

Safety Data

• Hazardous Substances Data: 314768-98-4(Hazardous Substances Data)

Upstream product

• 41994-44-9 5-chloro-2-nitrobenzoyl chloride 
• 40763-96-0 2-nitro-5-chlorobenzamide 
• 2516-95-2 5-chloro-2-nitrobenzoic acid 

Downstream Products

• 314769-09-0 2-(3'-Methoxyphenyl)-6-(4-methylpiperidinyl)-4-quinazolinone 

Relevant articles and documents

2-phenyl-4-quinazolinone compounds, 2-phenyl-4-alkoxy-quinazoline compounds and their pharmaceutical compositions

Two series of 6,7,2′,3′,4′,5′-substituted 2-phenyl-4-quinazolinones and 6,2′,3′,4′,5′-substituted 2,3-dihydro-2-phenyl-4-quinazolinones are synthesized and evaluated for cytotoxicity against a panel of human tumor cell lines, such as epidermoid carcinoma of the nasopharynx (KB), lung carcinoma (A-549), ileocecal carcinoma (HCT-8), breast cancer (MCF-7), melanoma (SKMEL-2), ovarian cancer (1A9), glioblastoma (U-87-MG), bone (HOS), P-gp-expressing epidermoid carcinoma of the nasopharynx (KB-VIN), and prostate cancer (PC3) cell lines, and some of the compounds are found potent. The present invention also synthesizes 2-phenyl-4-alkoxy-quinazoline compounds, wherein some of the compounds exhibit antiplatelet activity.

6-alkylamino- and 2,3-dihydro-3′-methoxy-2-phenyl-4-quinazolinones and related compounds: Their synthesis, cytotoxicity, and inhibition of tubulin polymerization

As part of our continuing search for potential anticancer candidates among 2-phenyl-4-quinolones and 2-phenyl-4-quinazolinones, two series of 6,7,2′,3′,4′,5′-substituted 2-phenyl-4-quinazolinones and 6,2′,3′,4′,5′-substituted 2,3-dihydro-2-phenyl-4-quinazolinones were synthesized and evaluated for cytotoxicity and as inhibitors of tubulin polymerization. In general, a good correlation was found between the two activities. Five of the 6-substituted heterocyclic 2-phenyl-4-quinozolinones (37-51) showed significant cytotoxicity against a panel of human tumor cell lines with EC50 values in the low micromolar to nanomolar concentration ranges. Compound 38 was the most potent of these compounds, as well as the most potent inhibitor of tubulin polymerization in this series. The activity of 38 was in the same range as those of the antimitotic natural products, colchicine, podophyllotoxin, and combretastatin A-4. Substituted 2-phenyl-4-quinazolinones and 2,3-dihydro-2-phenyl-4-quinazolinones also displayed highly selective cytotoxicity against the ovarian cancer 1A9 and P-gp resistant KB-VIN cell lines.