40763-96-0

Basic information

• Product Name: 5-CHLORO-2-NITROBENZAMIDE
• Synonyms: 5-CHLORO-2-NITROBENZAMIDE;TIMTEC-BB SBB010015;5-CHLORO-2-NITROBENZAMIDE, 98+%;2-Carbamoyl-4-chloronitrobenzene
• CAS NO: 40763-96-0
• Molecular Formula: C₇H₅ClN₂O₃
• Molecular Weight: 200.58
• Product Categories: Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Amides;Carbonyl Compounds;Organic Building Blocks;Building Blocks;Carbonyl Compounds;Chemical Synthesis;Organic Building Blocks
• Mol File: 40763-96-0.mol
• Article Data: 11

Chemical Properties

• Melting Point: 157-160 °C(lit.)
• Boiling Point: 301.7 °C at 760 mmHg
• Flash Point: 136.3 °C
• Appearance: /
• Density: 1.52 g/cm³
• Vapor Pressure: 0.00103mmHg at 25°C
• Refractive Index: 1.624
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility: soluble in Methanol
• PKA: 14.50±0.50(Predicted)
• BRN: 2267797
• CAS DataBase Reference: 5-CHLORO-2-NITROBENZAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-CHLORO-2-NITROBENZAMIDE(40763-96-0)
• EPA Substance Registry System: 5-CHLORO-2-NITROBENZAMIDE(40763-96-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-37
• WGK Germany: 3
• Hazardous Substances Data: 40763-96-0(Hazardous Substances Data)

Usage

General Description

5-Chloro-2-Nitrobenzamide is a synthesized chemical compound that belongs to a class of organic compounds known as nitrobenzamides, which have a structure containing a benzene ring that is bonded to an amide group and a nitro group. It is highly known and registered for its distinct systematic chemical name, 5-Chloro-2-Nitrobenzamide, based on IUPAC (International Union of Pure and Applied Chemistry) rules. The molecular formula for this chemical is C7H5ClN2O4 and it has a molecular weight of about 214.58 g/mol. 5-CHLORO-2-NITROBENZAMIDE, like others of its group, is potentially used in various chemical and pharmaceutical applications. However, safe handling and precautionary measures should be applied due to its harmful nature.

InChI:InChI=1/C7H5ClN2O3/c8-4-1-2-6(10(12)13)5(3-4)7(9)11/h1-3H,(H2,9,11)

Upstream product

• 41994-44-9 5-chloro-2-nitrobenzoyl chloride 
• 2516-95-2 5-chloro-2-nitrobenzoic acid 
• 618-48-4 3-chlorobenzamide 
• 7697-37-2 nitric acid 
• 18370-10-0 3-chloro-N-methyl-benzamide 

Downstream Products

• 5202-85-7 2-Amino-5-chlorobenzamide 
• 1159524-75-0 C₁₁H₆Cl₂N₂O₃S 
• 1026-12-6 6-chloro-2-phenyl-3H-quinazolin-4-one 
• 93986-08-4 6-chloro-2-thioxo-3-m-tolyl-2,3-dihydroquinazolin-4(1H)-one 
• 84772-27-0 6-chloro-3-phenyl-2-thioxo-2,3-dihydroquinazolin-4(1H)-one 
• 142439-69-8 5--2-nitrobenzonitrile 
• 105189-29-5 6-Methylsulfanyl-2-[3-(3-piperidin-1-ylmethyl-phenoxy)-propyl]-3H-quinazolin-4-one 
• 156149-36-9 2-azido-5-chlorobenzonitrile 
• 5922-60-1 2-amino-5-chlorobenzonitrile 

Relevant articles and documents

Anthranilamide-based 2-phenylcyclopropane-1-carboxamides, 1,1'-biphenyl-4-carboxamides and 1,1'-biphenyl-2-carboxamides: Synthesis biological evaluation and mechanism of action

Several anthranilamide-based 2-phenylcyclopropane-1-carboxamides 13a-f, 1,1’-biphenyl-4-carboxamides 14a-f and 1,1’-biphenyl-2-carboxamides 17a-f were obtained by a multistep procedure starting from the (1S,2S)-2-phenylcyclopropane-1-carbonyl chloride 11, the 1,1'-biphenyl-4-carbonyl chloride 12 or the 1,1'-biphenyl-2-carbonyl chloride 16 with the appropriate anthranilamide derivative 10a-f. Derivatives 13a-f, 14a-f and 17a-f showed antiproliferative activity against human leukemia K562?cells. Among these derivatives 13b, 14b and 17b exerted a particular cytotoxic effect on tumor cells. Derivative 17b showed a better antitumoral effect on K562?cells than 13b and 14b. Analyses performed to explore 17b mode of action revealed that it induced an arrest in G2/M phase of cell cycle which was consequent to DNA lesions as demonstrated by the increase in phospho-ATM and γH2AX, two known markers of DNA repair response system. The effect of 17b was also related to ROS generation, activation of JNK and induction of caspase-3 dependent apoptosis.

2-Aryl-4-Quinazolinones And Their Pharmaceutical Compositions

Provided is a compound of the formula I or a pharmaceutically acceptable salt, solvate or stereoisomer thereof: wherein Ar represents R5, R6, R7, R8, R1′, R2′, R3′, R4

Discovery of betrixaban (PRT054021), N-(5-chloropyridin-2-yl)-2-(4-(N,N-dimethylcarbamimidoyl)benzamido)-5-methoxybenzamide, a highly potent, selective, and orally efficacious factor Xa inhibitor

Systematic SAR studies of in vitro factor Xa inhibitory activity around compound 1 were performed by modifying each of the three phenyl rings. A class of highly potent, selective, efficacious and orally bioavailable direct factor Xa inhibitors was discovered. These compounds were screened in hERG binding assays to examine the effects of substitution groups on the hERG channel affinity. From the leading compounds, betrixaban (compound 11, PRT054021) has been selected as the clinical candidate for development.