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315233-72-8

3-(4-fluorophenyl)-7-hydroxy-2-(trifluoromethyl)-4H-chromen-4-one is a complex organic compound belonging to the class of flavonoids, specifically a derivative of chromone. This molecule features a chromone core structure, which consists of a benzopyran ring system with a carbonyl group at position 4. The compound is characterized by the presence of a 4-fluorophenyl group at position 3, a hydroxyl group at position 7, and a trifluoromethyl group at position 2. The combination of these functional groups endows the molecule with unique chemical and biological properties, making it a potential candidate for pharmaceutical applications, such as anti-inflammatory, antioxidant, or anticancer activities. However, further research is needed to explore its potential therapeutic uses and optimize its structure for improved efficacy and safety.

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  • 315233-72-8 Structure

  • Basic information

    1. Product Name: 3-(4-fluorophenyl)-7-hydroxy-2-(trifluoromethyl)-4H-chromen-4-one
    2. Synonyms: 3-(4-fluorophenyl)-7-hydroxy-2-(trifluoromethyl)-4H-chromen-4-one
    3. CAS NO:315233-72-8
    4. Molecular Formula: C16H8F4O3
    5. Molecular Weight: 324.2265328
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 315233-72-8.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 3-(4-fluorophenyl)-7-hydroxy-2-(trifluoromethyl)-4H-chromen-4-one(CAS DataBase Reference)
    10. NIST Chemistry Reference: 3-(4-fluorophenyl)-7-hydroxy-2-(trifluoromethyl)-4H-chromen-4-one(315233-72-8)
    11. EPA Substance Registry System: 3-(4-fluorophenyl)-7-hydroxy-2-(trifluoromethyl)-4H-chromen-4-one(315233-72-8)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 315233-72-8(Hazardous Substances Data)

315233-72-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 315233-72-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,1,5,2,3 and 3 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 315233-72:
(8*3)+(7*1)+(6*5)+(5*2)+(4*3)+(3*3)+(2*7)+(1*2)=108
108 % 10 = 8
So 315233-72-8 is a valid CAS Registry Number.

315233-72-8Relevant articles and documents

Synthesis and tautomerization of hydroxylated isoflavones bearing heterocyclic hemi-aminals

Frasinyuk, Mykhaylo S.,Bondarenko, Svitlana P.,Khilya, Volodymyr P.,Liu, Chunming,Watt, David S.,Sviripa, Vitaliy M.

, p. 1053 - 1067 (2015/08/03)

The aminomethylation of hydroxylated isoflavones with 2-aminoethanol, 3-amino-1-propanol, 4-amino-1-butanol, and 5-amino-1-pentanol in the presence of excess formaldehyde led principally to 9-(2-hydroalkyl)-9,10-dihydro-4H,8H-chromeno[8,7-e][1,3]-oxazin-4-ones 4 and/or the tautomeric 7-hydroxy-8-(1,3-oxazepan-3-ylmethyl)-4H-chromen-4-ones 5. The ratio of these tautomers was dependent on solvent polarity, electronic effects of aryl substituents in the isoflavone and the structure of the amino alcohol. NMR studies confirmed the interconversion of tautomeric forms.

7-Hydroxy-benzopyran-4-one derivatives: A novel pharmacophore of peroxisome proliferator-activated receptor α and -γ (PPARα and γ) dual agonists

Matin, Azadeh,Gavande, Navnath,Kim, Moon S.,Yang, Nancy X.,Salam, Noeris K.,Hanrahan, Jane R.,Roubin, Rebecca H.,Hibbs, David E.

experimental part, p. 6835 - 6850 (2010/04/04)

Design, synthesis, and in vitro bioevaluation of a new class of potential dual PPARα and γ agonists discovered through a structure-driven design paradigm are described. The 7-hydroxy-benzopyran-4-one moiety (includes flavones, flavanones, and isoflavones) is the key pharmacophore of these novel molecules, exhibiting similarity to the core structure of both fibrates and thiazolidinediones. New lead PPAR ligands were identified from "natraceuticals" and synthetic analogues. In total, 77 molecules, including chalcones, flavones, flavanones, isoflavones, and pyrazole derivatives, were screened and structure-activity relationship studies of the dual agonists undertaken. Compounds 68, 70, 72, and 76 were identified as novel and potent dual PPARα and γ agonists. These novel molecules may have the potential to be the future leads in PPAR-related disorders, including type II diabetes mellitus and metabolic syndrome. 2009 American Chemical Society.

FLAVONOID PPAR AGONISTS

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Page/Page column 40; 76, (2009/04/25)

The present invention relates to PPAR agonists, and their use in therapy including the treatment of disease. In particular, the invention relates to flavonoid compounds which are PPAR-gamma agonists and/or PPAR alpha/gamma dual agonists.

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