3-(4-fluorophenyl)-7-hydroxy-2-(trifluoromethyl)-4H-chromen-4-one

Base Information

• Chemical Name: 3-(4-fluorophenyl)-7-hydroxy-2-(trifluoromethyl)-4H-chromen-4-one
• CAS No.: 315233-72-8
• Molecular Formula: C₁₆H₈F₄O₃
• Molecular Weight: 324.231
• Mol file: 315233-72-8.mol

Synonyms:3-(4-fluorophenyl)-7-hydroxy-2-(trifluoromethyl)-4H-chromen-4-one

Chemical Property of 3-(4-fluorophenyl)-7-hydroxy-2-(trifluoromethyl)-4H-chromen-4-one

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

3-(4-FLUORO-PHENYL)-7-HYDROXY-2-TRIFLUOROMETHYL-CHROMEN-4-ONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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Useful:

Technology Process of 3-(4-fluorophenyl)-7-hydroxy-2-(trifluoromethyl)-4H-chromen-4-one

There total 1 articles about 3-(4-fluorophenyl)-7-hydroxy-2-(trifluoromethyl)-4H-chromen-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

4'-fluoro-2,4-dihydroxydeoxybenzoin (15485-70-8) + trifluoroacetic anhydride (407-25-0) → 3-(4-fluorophenyl)-7-hydroxy-2-(trifluoromethyl)-4H-chromen-4-one (315233-72-8)

Guidance literature:

With pyridine; at 25 ℃; for 48h; Cooling with ice;

DOI:10.1039/c4ob02137a

Reference yield: 70.0%

3-(4-fluorophenyl)-7-hydroxy-2-(trifluoromethyl)-4H-chromen-4-one (315233-72-8) → 3-(2,4-dihydroxyphenyl)-4-(4-fluorophenyl)-5-trifluoromethyl-1H-pyrazole (385401-09-2)

Guidance literature:

With hydrazine hydrate; In ethanol; water; for 8h; Reflux;

DOI:10.1021/jm900964r

Reference yield: 65.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 3-(4-fluorophenyl)-7-hydroxy-2-(trifluoromethyl)-4H-chromen-4-one (315233-72-8) + propan-1-ol-3-amine (156-87-6) → 3-(4-fluorophenyl)-7-hydroxy-8-{[(3-hydroxypropyl)amino]-methyl}-2-(trifluoromethyl)-4H-chromen-4-one

Guidance literature:

formaldehyd; 3-(4-fluorophenyl)-7-hydroxy-2-(trifluoromethyl)-4H-chromen-4-one; propan-1-ol-3-amine; With dmap; In water; isopropyl alcohol; at 80 ℃;

With hydrogenchloride; In ethanol; water; at 80 ℃;

DOI:10.1039/c4ob02137a

upstream raw materials:

4'-fluoro-2,4-dihydroxydeoxybenzoin

trifluoroacetic anhydride

Downstream raw materials:

3-(2,4-dihydroxyphenyl)-4-(4-fluorophenyl)-5-trifluoromethyl-1H-pyrazole

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