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315712-44-8

methyl 2-[(cyclohexylcarbonyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 315712-44-8 Structure

  • Basic information

    1. Product Name: methyl 2-[(cyclohexylcarbonyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate
    2. Synonyms: methyl 2-[(cyclohexylcarbonyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate
    3. CAS NO:315712-44-8
    4. Molecular Formula: C17H23NO3S
    5. Molecular Weight: 321.43442
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 315712-44-8.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: methyl 2-[(cyclohexylcarbonyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate(CAS DataBase Reference)
    10. NIST Chemistry Reference: methyl 2-[(cyclohexylcarbonyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate(315712-44-8)
    11. EPA Substance Registry System: methyl 2-[(cyclohexylcarbonyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate(315712-44-8)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 315712-44-8(Hazardous Substances Data)

315712-44-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 315712-44-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,1,5,7,1 and 2 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 315712-44:
(8*3)+(7*1)+(6*5)+(5*7)+(4*1)+(3*2)+(2*4)+(1*4)=118
118 % 10 = 8
So 315712-44-8 is a valid CAS Registry Number.

315712-44-8Downstream Products

315712-44-8Relevant articles and documents

Synthesis and pharmacological characterization of 2-(acylamino)thiophene derivatives as metabolically stable, orally effective, positive allosteric modulators of the GABAB receptor

Mugnaini, Claudia,Pedani, Valentina,Casu, Angelo,Lobina, Carla,Casti, Alberto,MacCioni, Paola,Porcu, Alessandra,Giunta, Daniela,Lamponi, Stefania,Solinas, Maurizio,Dragoni, Stefania,Valoti, Massimo,Colombo, Giancarlo,Castelli, Maria Paola,Gessa, Gian Luigi,Corelli, Federico

, p. 3620 - 3635 (2013/06/27)

Two recently reported hit compounds, COR627 and COR628, underpinned the development of a series of 2-(acylamino)thiophene derivatives. Some of these compounds displayed significant activity in vitro as positive allosteric modulators of the GABAB receptor by potentiating GTPγS stimulation induced by GABA at 2.5 and 25 μM while failing to exhibit intrinsic agonist activity. Compounds were also found to be effective in vivo, potentiating baclofen-induced sedation/hypnosis in DBA mice when administered either intraperitoneally or intragastrically. Although displaying a lower potency in vitro than the reference compound GS39783, the new compounds 6, 10, and 11 exhibited a higher efficacy in vivo: combination of these compounds with a per se nonsedative dose of baclofen resulted in shorter onset and longer duration of the loss of righting reflex in mice. Test compounds showed cytotoxic effects at concentrations comparable to or higher than those of GS39783 or BHF177.

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