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CAS

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318684-82-1

6,7-difluoroquinolin-3-amine is a quinoline derivative, a heterocyclic aromatic organic compound, featuring two fluorine atoms on the 6th and 7th positions of the quinoline ring and an amine group on the 3rd position. The incorporation of fluorine atoms enhances the metabolic stability, lipophilicity, and binding affinity of the molecule, while the amine group makes it a potential precursor for synthesizing other biologically active molecules. 6,7-difluoroquinolin-3-amine holds promise for applications in drug discovery and development.

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  • 318684-82-1 Structure

  • Basic information

    1. Product Name: 6,7-difluoroquinolin-3-amine
    2. Synonyms: 6,7-difluoroquinolin-3-amine
    3. CAS NO:318684-82-1
    4. Molecular Formula: C9H6F2N2
    5. Molecular Weight: 180.1541464
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 318684-82-1.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 320.9±37.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.413±0.06 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. PKA: 3.16±0.28(Predicted)
    10. CAS DataBase Reference: 6,7-difluoroquinolin-3-amine(CAS DataBase Reference)
    11. NIST Chemistry Reference: 6,7-difluoroquinolin-3-amine(318684-82-1)
    12. EPA Substance Registry System: 6,7-difluoroquinolin-3-amine(318684-82-1)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 318684-82-1(Hazardous Substances Data)

318684-82-1 Usage

Uses

Used in Pharmaceutical Industry:
6,7-difluoroquinolin-3-amine is used as a key intermediate in the synthesis of various pharmaceutical compounds for its ability to improve metabolic stability, lipophilicity, and binding affinity due to the presence of fluorine atoms.
Used in Drug Discovery and Development:
6,7-difluoroquinolin-3-amine serves as a valuable building block for creating new drug candidates, capitalizing on its potential to be modified and functionalized for specific therapeutic targets.

Check Digit Verification of cas no

The CAS Registry Mumber 318684-82-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,1,8,6,8 and 4 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 318684-82:
(8*3)+(7*1)+(6*8)+(5*6)+(4*8)+(3*4)+(2*8)+(1*2)=171
171 % 10 = 1
So 318684-82-1 is a valid CAS Registry Number.

318684-82-1Downstream Products

318684-82-1Relevant articles and documents

Synthetic method of 3-amino-6,7-difluoroquinoline

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, (2018/10/19)

The invention provides a synthetic method of 3-amino-6,7-difluoroquinoline. The synthetic method comprises the following steps: firstly, adding a solvent into glycerol, adding 3,4-difluoroaniline anda catalyst and heating and reacting to obtain 6,7-difluoroquinoline; secondly, slowly adding N-bromosuccinimide and the solvent into the 6,7-difluoroquinoline, heating and reacting to obtain 3-bromo-6,7-difluoroquinoline; thirdly, adding aminomethoxytert-butyl ester, the solvent and the catalyst into the 3-bromo-6,7-difluoroquinoline for reacting to obtain 3-N-t-butoxycarbonylamino-6,7-difluoroquinoline; fourthly, adding hydrochloric acid and the solvent into 3-N-t-butoxycarbonyl amino-6,7-difluoroquinoline for reacting to obtain 3-amino-6,7-difluoroquinoline. The synthetic method of the 3-amino-6,7-difluoroquinoline, disclosed by the invention, has the advantages of simple route, low-priced and easily-obtained raw materials, convenience in post treatment, high product yield and suitability for an enlargement synthetic route of the 3-amino-6,7-difluoroquinoline.

Benzo[f]naphthyridine derivatives, their preparation and compositions containing them

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, (2008/06/13)

Benzo[f]naphthyridine derivatives of formula (I): benzo[f]naphthyridine derivatives and benzo[f]naphthyridine esters of formula (IVa): aminoquinoline derivatives of formula (X): processes for preparing such compounds; and compositions comprising them.

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