- Deciphering DNA-based asymmetric catalysis through intramolecular Friedel-Crafts alkylations
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We describe asymmetric intramolecular Friedel-Crafts alkylations with a DNA-based hybrid catalyst and propose a plausible binding model. This study shows promise for studying relationships between the helical chirality of DNA and enantioselectivity of the chemical reaction.
- Park, Soyoung,Ikehata, Keiichi,Watabe, Ryo,Hidaka, Yuta,Rajendran, Arivazhagan,Sugiyama, Hiroshi
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supporting information
p. 10398 - 10400,3
(2020/09/09)
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- Synthesis and biological evaluation of novel compounds within a class of 3-aminochroman derivatives with dual 5-HT1A receptor and serotonin transporter affinity
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Compounds containing a 5-carbamoyl-8-fluoro-3-amino-3,4-dihydro-2H-1- benzopyran and a 3-alkylindole moiety linked through a common basic nitrogen were prepared and evaluated for 5-HT1A affinity, serotonin rat transporter affinity, and functional antagonist activity in vitro. 26a was found to be the most potent and selective compound in this series and was shown to possess neurochemical activity in vivo by producing acute and rapid increases in 5-HT in the rat frontal cortex.
- Hatzenbuhler, Nicole T.,Evrard, Deborah A.,Harrison, Boyd L.,Huryn, Donna,Inghrim, Jennifer,Kraml, Christina,Mattes, James F.,Mewshaw, Richard E.,Zhou, Dahui,Hornby, Geoffrey,Lin, Qian,Smith, Deborah L.,Sullivan, Kelly M.,Schlechter, Lee E.,Beyer, Chad E.,Andree, Terrance H.
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p. 4785 - 4789
(2007/10/03)
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- 3-AMINO CHOMAN AND 2-AMINO TETRALIN DERIVATIVES
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3-Amino chroman and 2-amino tetralin derivatives and compositions containing such compounds are disclosed. Methods of using the 3-amino chroman and 2-amino tetralin compounds and compositions containing such compounds in the treatment of serotonin disorders, such as depression and anxiety, are also disclosed.
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Page/Page column 78
(2010/02/10)
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- Piperazine derivatives
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Piperazine derivatives of the formula I in which R1, m, k and R2have the meanings indicated in claim1, are potent 5-HT1Aagonists and exhibit 5-HT-reuptake-inhibiting actions and are suitable for the treatment and prophylaxis of anxiety states, depression, schizophrenia, obsessions, tardive dyskinesias, learning disorders, age-dependent memory disorders, for positively affecting obsessive-compulsive disorder, and also for the treatment and for the control of the sequelae of cerebral infarcts such as stroke and cerebral ischaemias.
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