319-72-2

Basic information

• Product Name: 4-(5-FLUORO-1H-INDOL-3-YL)-BUTYRIC ACID
• Synonyms: 4-(5-FLUORO-1H-INDOL-3-YL)-BUTYRIC ACID;5-FLUOROINDOLE-3-BUTYRIC ACID;4-(5-fluoro-1h-indol-3-yl)butanoic acid;REF DUPL: 5-Fluoroindole-3-butyric acid;1H-Indole-3-butanoic acid, 5-fluoro-
• CAS NO: 319-72-2
• Molecular Formula: C₁₂H₁₂FNO₂
• Molecular Weight: 221.23
• Product Categories: pharmacetical;Carboxylic Acids;Pyrroles & Indoles;Carboxylic Acids;Pyrroles & Indoles
• Mol File: 319-72-2.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 429.6 °C at 760 mmHg
• Flash Point: 213.6 °C
• Appearance: /
• Density: 1.328 g/cm³
• Vapor Pressure: 3.84E-08mmHg at 25°C
• Refractive Index: 1.625
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility: Chloroform (Slightly, Heated, Sonicated), DMSO (Slightly)
• PKA: 4.76±0.10(Predicted)
• CAS DataBase Reference: 4-(5-FLUORO-1H-INDOL-3-YL)-BUTYRIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(5-FLUORO-1H-INDOL-3-YL)-BUTYRIC ACID(319-72-2)
• EPA Substance Registry System: 4-(5-FLUORO-1H-INDOL-3-YL)-BUTYRIC ACID(319-72-2)

Safety Data

• Hazardous Substances Data: 319-72-2(Hazardous Substances Data)

Usage

Uses

5-Fluoroindole-3-butyric Acid is used in preparation of Aminochroman and Aminotetralin derivatives, which are useful in the treatment of serotonin-mediated disorders.

InChI:InChI=1/C12H12FNO2/c13-9-4-5-11-10(6-9)8(7-14-11)2-1-3-12(15)16/h4-7,14H,1-3H2,(H,15,16)

Upstream product

• 27983-42-2 5-carboethoxypentanal 
• 7394-69-6 γ-(2-Carboxy-5-fluor-3-indolyl)buttersaeure 
• 843652-73-3 5-fluoro-3-(3-isocyanopropyl)-1H-indole 
• 371-14-2 4-fluorophenylhydrazine 
• 191013-68-0 3-(3-Bromopropyl)-5-fluoro-1H-indole 
• 141071-80-9 3-(5-fluoro-1H-indol-3-yl)propan-1-ol 
• 319-73-3 ethyl 4-(5-fluoro-1H-indol-3-yl)butanoate 

Downstream Products

• 843654-83-1 4-(5-fluoroindol-3-yl)butanal 
• 143682-57-9 5-Fluoro-3-[4-(4-phenyl-3,6-dihydro-2H-pyridin-1-yl)-butyl]-1H-indole 
• 143682-30-8 4-(5-Fluoro-1H-indol-3-yl)-1-(4-phenyl-3,6-dihydro-2H-pyridin-1-yl)-butan-1-one 

Relevant articles and documents

Deciphering DNA-based asymmetric catalysis through intramolecular Friedel-Crafts alkylations

We describe asymmetric intramolecular Friedel-Crafts alkylations with a DNA-based hybrid catalyst and propose a plausible binding model. This study shows promise for studying relationships between the helical chirality of DNA and enantioselectivity of the chemical reaction.

3-AMINO CHOMAN AND 2-AMINO TETRALIN DERIVATIVES

3-Amino chroman and 2-amino tetralin derivatives and compositions containing such compounds are disclosed. Methods of using the 3-amino chroman and 2-amino tetralin compounds and compositions containing such compounds in the treatment of serotonin disorders, such as depression and anxiety, are also disclosed.