- A 2, 4 - difluoro - 3, 5 - dichloro nitrobenzene synthesis of 1, 3, 5 - trichloro - 2, 4, 6 - trifluorobenzene
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The invention discloses a method for synthesizing 1,3,5-trichloro-2,4,6-trifluorobenzene from 2,4-difluoro-3,5-dichloronitrobenzene. The method comprises performing chlorination reaction on 2,4-difluoro-3,5-dichloronitrobenzene in chlorine atmosphere to obtain a chloride, and controlling the chlorination reaction temperature to 160-195 DEG C; performing nitration reaction on the chloride in a mixed acid solution of sulfuric acid and nitric acid to obtain a nitro compound, and controlling the nitration reaction temperature to 60-110 DEG C; and performing fluorination reaction on the nitro compound with a fluoride under a waterless condition so as to obtain 1,3,5-trichloro-2,4,6-trifluorobenzene, and controlling the fluorination reaction temperature to 80-200 DEG C. The product synthesized by the method is high in selectivity, and the yield and the purity of products of all steps are relatively high, and operation is simple.
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Paragraph 0065; 0066; 0067; 0068; 0069; 0070
(2017/08/25)
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- METHOD FOR THE PRODUCTION OF 1,3,5-TRIFLUORO-2,4,6-TRICHLOROBENZENE FROM FLUOROBENZENE DERIVATIVES
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Method for the production of 1,3,5-trifluoro-2,4,6-trichlorobenzene from fluorobenzene, comprising steps A) and B): A) chlorination of fluorobenzene derivatives of formula (II), in which X = fluorine or H, Z = nitro, bromo or chloro and n = 0 or 1-4 and B) fluorination of the distillation residue and separation by distillation of the 1,3,5-trifluoro-2,4,6-trichlorobenzene thus produced.
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Page/Page column 10
(2008/06/13)
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- Chloro- and bromo-defluorination of hexafluorobenzene and octafluorotoluene
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Halo(chloro, bromo)defluorination of perfluorobenzaene and toluene efficiently occurs under the action of appropriate alkali metal halides in the presence of hexaethylguanidinium chloride in catalytic amount. The relative efficiency of halide anions and m
- Shipilov,Zolotkova,Igumnov
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p. 1117 - 1120
(2007/10/03)
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- Solvents for use in fluorination reactions
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A method of fluorinating an organic compound comprising reacting an organic compound with a fluorinating agent characterized in that a perfluorocarbon compound is present in the reaction medium. The perfluorocarbon compound may replace an amount of a solvent which would otherwise be required for the reaction to proceed efficiently. The perfluorocarbon compound is readily recoverable after reaction and may be re-used in subsequent reactions. Additives to the reaction medium, such as 18-crown-6, may increase the amoun of solvent which may be replaced. The method is beneficial where solvent consumption would otherwise be large, or where solvent recovery would otherwise be difficult.
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- Perfluorocarbon fluids as solvent replacements
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Perfluoroperhydrophenanthrene 1 may be used as a 'bulking agent' to minimise the problem of solvent recovery in halogen exchange ('Halex') reactions for the preparation of octafluorocyclopentene 8, and chlorofluoro-pyridine, -pyrimidine and -benzene derivatives. New 'one-pot' procedures for the syntheses of hexafluorobut-2-yne 3, octafluorobut-2-ene 11 and hexafluorocyclobutene 7 are described.
- Chambers, Richard D.,Edwards, Andrew R.
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p. 3623 - 3627
(2007/10/03)
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- LA FLUORATION PAR KF DE PERHALOGENES ORGANIQUES AROMATIQUES EN PRESENCE DE FAIBLES QUANTITES DE SULFOLANE OU D'EAU. SPECTRES DE MASSES DES MELANGES OBTENUS EN SERIE BENZENIQUE
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The fluorinations of perhalogenated aromatic compounds with KF are carried out in sealed tubes in presence of inert gas.The addition of small quantities of aprotic solvent promotes the fluorination of pentachloropyridine above 180 deg C; these fluorinatio
- Hitzke, J.
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p. 101 - 116
(2007/10/02)
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