319-88-0

Basic information

• Product Name: 1,3,5-Trichloro-2,4,6-trifluorobenzene
• Synonyms: 1,3,5-trichloro-2,4,6-trifluoro-benzen;1,3,5-trifluorotrichlorobenzene;2,4,6-trifluorotrichlorobenzene;benzene,1,3,5-trichloro-2,4,6-trifluoro-;sym-trichlorotrifluorobenzene;sym-trifluorotrichlorobenzene;1,3,5-TRICHLOROTRIFLUOROBENZENE;1,3,5-TRICHLORO-2,4,6-TRIFLUOROBENZENE
• CAS NO: 319-88-0
• Molecular Formula: C₆Cl₃F₃
• Molecular Weight: 235.42
• EINECS: 206-273-4
• Mol File: 319-88-0.mol

Chemical Properties

• Melting Point: 62-64 °C(lit.)
• Boiling Point: 79.5 °C12 mm Hg(lit.)
• Flash Point: 216 °F
• Appearance: White to off-white crystals
• Density: 1.6575 (estimate)
• Vapor Pressure: 0.477mmHg at 25°C
• Refractive Index: 1.505
• BRN: 958307
• CAS DataBase Reference: 1,3,5-Trichloro-2,4,6-trifluorobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3,5-Trichloro-2,4,6-trifluorobenzene(319-88-0)
• EPA Substance Registry System: 1,3,5-Trichloro-2,4,6-trifluorobenzene(319-88-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• RTECS: DC2450000
• HazardClass: IRRITANT
• Hazardous Substances Data: 319-88-0(Hazardous Substances Data)

Usage

Uses

Used in Chemical Synthesis:
1,3,5-Trichloro-2,4,6-trifluorobenzene is used as a reagent in various chemical synthesis processes. Its unique combination of chlorine and fluorine atoms allows it to act as an intermediate in the production of other organic compounds, particularly those requiring halogenated aromatic structures.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 1,3,5-trichlorotrifluorobenzene is used as a building block for the synthesis of various drug molecules. Its specific halogenated structure can contribute to the development of new drugs with improved pharmacological properties, such as enhanced solubility, stability, and bioavailability.
Used in Agrochemical Industry:
1,3,5-Trichloro-2,4,6-trifluorobenzene is also utilized in the agrochemical industry for the synthesis of active ingredients in pesticides and herbicides. Its chemical properties make it suitable for the development of compounds that can effectively control pests and weeds in agricultural settings.
Used in Material Science:
In the field of material science, 1,3,5-trichlorotrifluorobenzene can be employed in the development of new materials with specific properties. Its halogenated structure can contribute to the creation of materials with improved thermal stability, chemical resistance, and other desirable characteristics for various applications.

InChI:InChI=1/C6Cl3F3/c7-1-4(10)2(8)6(12)3(9)5(1)11

Upstream product

• 372-38-3 1,3,5-trifluorobenzene 
• 1198-56-7 1,2,3,5-tetrachloro-4,6-difluorobenzene 
• 15952-70-2 2,4-difluoro-3,5-dichloro-nitrobenzene 
• 118-74-1 hexachlorobenzene 
• 319-87-9 pentachlorofluorobenzene 
• 399-36-0 N-(2,4-difluoro-phenyl)-acetamide 
• 372-39-4 3,5-difluoroaniline 
• 364-30-7 2-amino-3,5-difluoronitrobenzene 
• 2265-94-3 1,3-difluoro-5-nitrobenzene 
• 392-56-3 Hexafluorobenzene 
• 363-64-4 1,3,5-trimethyl-2,4,6-trifluorobenzene 
• 598-88-9 1,2-dichloro-1,2-difluoroethene 

Downstream Products

• 2368-53-8 1,3-dichloro-2,4,6-trifluorobenzene 
• 2106-40-3 2-chloro-1,3,5-trifluorobenzene 
• 1489-53-8 1,2,3-trifluorobenzene 
• 372-38-3 1,3,5-trifluorobenzene 
• 367-23-7 1,2,4-trifluorobenzene 
• 53732-48-2 1,3,5-trilithium trifluoro benzene 
• 885515-05-9 trans-[Ni(3,5-C₆Cl₂F₃)2(AsMePh₂)2] 
• 885515-03-7 trans-[Ni(3,5-C₆Cl₂F₃)2(AsPh₃)2] 
• 885515-02-6 trans-[Ni(3,5-C₆Cl₂F₃)2(SbPh₃)2] 
• 2992-91-8 2,4,6-Cl₃-C₆F₂OH 
• 24812-12-2 3,5-Dichloro-2,4,6-trifluoro-phenol 
• 674289-03-3 ((2,4,6-trifluorobenzene-1,3,5-triyl)tris(ethyne-2,1-diyl))tris(trimethylsilane) 
• 13527-91-8 2,4,6-trichloro-3,5-difluoro-4-iodoaniline 
• 917341-47-0 (2E)-N-(3,5-difluorophenyl)cinnamamide 

Relevant articles and documents

A 2, 4 - difluoro - 3, 5 - dichloro nitrobenzene synthesis of 1, 3, 5 - trichloro - 2, 4, 6 - trifluorobenzene

The invention discloses a method for synthesizing 1,3,5-trichloro-2,4,6-trifluorobenzene from 2,4-difluoro-3,5-dichloronitrobenzene. The method comprises performing chlorination reaction on 2,4-difluoro-3,5-dichloronitrobenzene in chlorine atmosphere to obtain a chloride, and controlling the chlorination reaction temperature to 160-195 DEG C; performing nitration reaction on the chloride in a mixed acid solution of sulfuric acid and nitric acid to obtain a nitro compound, and controlling the nitration reaction temperature to 60-110 DEG C; and performing fluorination reaction on the nitro compound with a fluoride under a waterless condition so as to obtain 1,3,5-trichloro-2,4,6-trifluorobenzene, and controlling the fluorination reaction temperature to 80-200 DEG C. The product synthesized by the method is high in selectivity, and the yield and the purity of products of all steps are relatively high, and operation is simple.

METHOD FOR THE PRODUCTION OF 1,3,5-TRIFLUORO-2,4,6-TRICHLOROBENZENE FROM FLUOROBENZENE DERIVATIVES

Method for the production of 1,3,5-trifluoro-2,4,6-trichlorobenzene from fluorobenzene, comprising steps A) and B): A) chlorination of fluorobenzene derivatives of formula (II), in which X = fluorine or H, Z = nitro, bromo or chloro and n = 0 or 1-4 and B) fluorination of the distillation residue and separation by distillation of the 1,3,5-trifluoro-2,4,6-trichlorobenzene thus produced.

Chloro- and bromo-defluorination of hexafluorobenzene and octafluorotoluene

Halo(chloro, bromo)defluorination of perfluorobenzaene and toluene efficiently occurs under the action of appropriate alkali metal halides in the presence of hexaethylguanidinium chloride in catalytic amount. The relative efficiency of halide anions and m

Solvents for use in fluorination reactions

A method of fluorinating an organic compound comprising reacting an organic compound with a fluorinating agent characterized in that a perfluorocarbon compound is present in the reaction medium. The perfluorocarbon compound may replace an amount of a solvent which would otherwise be required for the reaction to proceed efficiently. The perfluorocarbon compound is readily recoverable after reaction and may be re-used in subsequent reactions. Additives to the reaction medium, such as 18-crown-6, may increase the amoun of solvent which may be replaced. The method is beneficial where solvent consumption would otherwise be large, or where solvent recovery would otherwise be difficult.

Perfluorocarbon fluids as solvent replacements

Perfluoroperhydrophenanthrene 1 may be used as a 'bulking agent' to minimise the problem of solvent recovery in halogen exchange ('Halex') reactions for the preparation of octafluorocyclopentene 8, and chlorofluoro-pyridine, -pyrimidine and -benzene derivatives. New 'one-pot' procedures for the syntheses of hexafluorobut-2-yne 3, octafluorobut-2-ene 11 and hexafluorocyclobutene 7 are described.

LA FLUORATION PAR KF DE PERHALOGENES ORGANIQUES AROMATIQUES EN PRESENCE DE FAIBLES QUANTITES DE SULFOLANE OU D'EAU. SPECTRES DE MASSES DES MELANGES OBTENUS EN SERIE BENZENIQUE

The fluorinations of perhalogenated aromatic compounds with KF are carried out in sealed tubes in presence of inert gas.The addition of small quantities of aprotic solvent promotes the fluorination of pentachloropyridine above 180 deg C; these fluorinatio