319-88-0

Basic information

• Product Name: 1,3,5-Trichloro-2,4,6-trifluorobenzene
• Synonyms: 1,3,5-trichloro-2,4,6-trifluoro-benzen;1,3,5-trifluorotrichlorobenzene;2,4,6-trifluorotrichlorobenzene;benzene,1,3,5-trichloro-2,4,6-trifluoro-;sym-trichlorotrifluorobenzene;sym-trifluorotrichlorobenzene;1,3,5-TRICHLOROTRIFLUOROBENZENE;1,3,5-TRICHLORO-2,4,6-TRIFLUOROBENZENE
• CAS NO: 319-88-0
• Molecular Formula: C₆Cl₃F₃
• Molecular Weight: 235.42
• EINECS: 206-273-4
• Mol File: 319-88-0.mol
• Article Data: 7

Chemical Properties

• Melting Point: 62-64 °C(lit.)
• Boiling Point: 79.5 °C12 mm Hg(lit.)
• Flash Point: 216 °F
• Appearance: White to off-white crystals
• Density: 1.6575 (estimate)
• Vapor Pressure: 0.477mmHg at 25°C
• Refractive Index: 1.505
• BRN: 958307
• CAS DataBase Reference: 1,3,5-Trichloro-2,4,6-trifluorobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3,5-Trichloro-2,4,6-trifluorobenzene(319-88-0)
• EPA Substance Registry System: 1,3,5-Trichloro-2,4,6-trifluorobenzene(319-88-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• RTECS: DC2450000
• HazardClass: IRRITANT
• Hazardous Substances Data: 319-88-0(Hazardous Substances Data)

Usage

Chemical Properties

white to off-white crystals

Uses

1,3,5-Trifluorotrichlorobenzene is a useful reagent.

InChI:InChI=1/C6Cl3F3/c7-1-4(10)2(8)6(12)3(9)5(1)11

Upstream product

• 118-74-1 hexachlorobenzene 
• 392-56-3 Hexafluorobenzene 
• 15952-70-2 2,4-difluoro-3,5-dichloro-nitrobenzene 
• 399-36-0 N-(2,4-difluoro-phenyl)-acetamide 
• 2265-94-3 1,3-difluoro-5-nitrobenzene 
• 363-64-4 1,3,5-trimethyl-2,4,6-trifluorobenzene 
• 598-88-9 1,2-dichloro-1,2-difluoroethene 
• 372-38-3 1,3,5-trifluorobenzene 
• 319-87-9 pentachlorofluorobenzene 
• 1198-56-7 1,2,3,5-tetrachloro-4,6-difluorobenzene 
• 372-39-4 3,5-difluoroaniline 
• 364-30-7 2-amino-3,5-difluoronitrobenzene 

Downstream Products

• 2368-53-8 1,3-dichloro-2,4,6-trifluorobenzene 
• 2106-40-3 2-chloro-1,3,5-trifluorobenzene 
• 1489-53-8 1,2,3-trifluorobenzene 
• 372-38-3 1,3,5-trifluorobenzene 
• 367-23-7 1,2,4-trifluorobenzene 
• 207393-28-0 Pt(3,5-dichlorotrifluorophenyl)2(1,5-cyclooctadiene) 
• 885515-05-9 trans-[Ni(3,5-C₆Cl₂F₃)2(AsMePh₂)2] 
• 885515-03-7 trans-[Ni(3,5-C₆Cl₂F₃)2(AsPh₃)2] 
• 885515-02-6 trans-[Ni(3,5-C₆Cl₂F₃)2(SbPh₃)2] 
• 80588-44-9 Pentafluorophenyl-(2,4,6-trichloro-3,5-difluoro-phenyl)-amine 
• 27602-27-3 3,5-dichloro-2,4,6-trifluoro-1-(trimethylsilyl)benzene 
• 674289-03-3 ((2,4,6-trifluorobenzene-1,3,5-triyl)tris(ethyne-2,1-diyl))tris(trimethylsilane) 
• 13527-91-8 2,4,6-trichloro-3,5-difluoro-4-iodoaniline 
• 917341-47-0 (2E)-N-(3,5-difluorophenyl)cinnamamide 

Relevant articles and documents

A 2, 4 - difluoro - 3, 5 - dichloro nitrobenzene synthesis of 1, 3, 5 - trichloro - 2, 4, 6 - trifluorobenzene

The invention discloses a method for synthesizing 1,3,5-trichloro-2,4,6-trifluorobenzene from 2,4-difluoro-3,5-dichloronitrobenzene. The method comprises performing chlorination reaction on 2,4-difluoro-3,5-dichloronitrobenzene in chlorine atmosphere to obtain a chloride, and controlling the chlorination reaction temperature to 160-195 DEG C; performing nitration reaction on the chloride in a mixed acid solution of sulfuric acid and nitric acid to obtain a nitro compound, and controlling the nitration reaction temperature to 60-110 DEG C; and performing fluorination reaction on the nitro compound with a fluoride under a waterless condition so as to obtain 1,3,5-trichloro-2,4,6-trifluorobenzene, and controlling the fluorination reaction temperature to 80-200 DEG C. The product synthesized by the method is high in selectivity, and the yield and the purity of products of all steps are relatively high, and operation is simple.

Chloro- and bromo-defluorination of hexafluorobenzene and octafluorotoluene

Halo(chloro, bromo)defluorination of perfluorobenzaene and toluene efficiently occurs under the action of appropriate alkali metal halides in the presence of hexaethylguanidinium chloride in catalytic amount. The relative efficiency of halide anions and m

Perfluorocarbon fluids as solvent replacements

Perfluoroperhydrophenanthrene 1 may be used as a 'bulking agent' to minimise the problem of solvent recovery in halogen exchange ('Halex') reactions for the preparation of octafluorocyclopentene 8, and chlorofluoro-pyridine, -pyrimidine and -benzene derivatives. New 'one-pot' procedures for the syntheses of hexafluorobut-2-yne 3, octafluorobut-2-ene 11 and hexafluorocyclobutene 7 are described.