320423-61-8

Basic information

• Product Name: 2-(4-FLUOROPHENOXY)BENZALDEHYDE
• Synonyms: 4'-Fluoro-2-formyldiphenyl ether
• CAS NO: 320423-61-8
• Molecular Formula: C₁₃H₉FO₂
• Molecular Weight: 216.21
• Product Categories: Aldehydes;C10 to C21;Carbonyl Compounds
• Mol File: 320423-61-8.mol

Chemical Properties

• Melting Point: 53-57 °C
• Boiling Point: 120-122°/0.05mm
• Flash Point: ≥230 °F
• Appearance: /
• Density: 1.229g/cm³
• Vapor Pressure: 0.00118mmHg at 25°C
• Refractive Index: 1.591
• Storage Temp.: 2-8°C
• Sensitive: Air Sensitive
• CAS DataBase Reference: 2-(4-FLUOROPHENOXY)BENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-FLUOROPHENOXY)BENZALDEHYDE(320423-61-8)
• EPA Substance Registry System: 2-(4-FLUOROPHENOXY)BENZALDEHYDE(320423-61-8)

Safety Data

• Hazard Codes: Xn
• Statements: 22-41
• Safety Statements: 26-39
• WGK Germany: 2
• HazardClass: IRRITANT
• Hazardous Substances Data: 320423-61-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-(4-Fluorophenoxy)benzaldehyde is used as an intermediate in the synthesis of pharmaceutical drugs for its ability to contribute to the development of biologically active molecules. Its fluoro-substituted phenyl ring and phenoxy group provide unique structural features that can enhance the pharmacological properties of the resulting compounds.
Used in Agrochemical Industry:
In the agrochemical industry, 2-(4-Fluorophenoxy)benzaldehyde is utilized as an intermediate in the synthesis of herbicides. Its chemical properties allow for the creation of herbicidal compounds that can effectively control unwanted plant growth while minimizing harm to desired crops.
Used in Research and Development:
2-(4-Fluorophenoxy)benzaldehyde is also employed in research and development processes for potential drug candidates and related compounds. Its unique structure and reactivity make it a valuable tool in the discovery and optimization of new pharmaceutical agents and agrochemicals.

InChI:InChI=1/C13H9FO2/c14-11-5-7-12(8-6-11)16-13-4-2-1-3-10(13)9-15/h1-9H

Upstream product

• 732306-64-8 bis(4-fluorophenyl)iodonium triflate 
• 71730-46-6 benzo[e][1,2,3]oxathiazine 2,2-dioxide 
• 371-41-5 4-Fluorophenol 
• 552-89-6 2-nitro-benzaldehyde 
• 1765-93-1 4-fluoroboronic acid 
• 859149-01-2 2-(4-fluorophenoxy)-O,N-dimethylbenzamide 

Downstream Products

• 859149-02-3 Methyl 2-amino-5-[2-(4-fluorophenoxy)-phenyl]thiazole-4-carboxylate 
• 1400883-57-9 C₁₉H₁₅FO₄S 
• 70764-39-5 [2-(4-fluorophenoxy)phenyl]methanol 
• 1393639-33-2 C₁₄H₁₃FN₂OS 
• 1393639-42-3 C₁₅H₁₃FO₃S 
• 866949-75-9 C₁₅H₁₄FNO₂S 
• 2839-49-8 2-fluoro-9H-xanthen-9-one 

Relevant articles and documents

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Ligand-free copper-catalyzed O-arylation of nitroarenes with phenols

The first example of ligand-free copper-catalyzed O-arylation of nitroarenes with phenols was developed, achieving unsymmetrical diaryl ethers in moderate to excellent yields. This arylation proceeded smoothly without promotion of the ligands, and displayed great functional group compatibility. Thus, the method represents a new, facile, and cost-effective approach to access unsymmetrical diaryl ethers.

The coupling of arylboronic acids with nitroarenes catalyzed by rhodium

The coupling of arylboronic acids with electron-deficient nitroarenes was realized for the first time by using a rhodium(I) catalyst under an air atmosphere, achieving unsymmetrical diaryl ethers with yields ranging from poor to good. From a deuterium labeling experiment, the oxygen atom is derived from ambient water. The efficiency of this reaction was demonstrated by its compatibility with fluoro, bromo, chloro, and trifluoromethyl groups.

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