32133-37-2

Basic information

• Product Name: DL-3,5-DIFLUOROPHENYLALANINE
• Synonyms: 2-AMINO-3-(3,5-DIFLUORO-PHENYL)-PROPIONIC ACID;3,5-DIFLUORO-DL-PHENYLALANINE;3,5-DIFLUOROPHENYLALANINE;DL-3,5-DIFLUOROPHENYLALANINE;TIMTEC-BB SBB000399;Difluorophenylalanine5;3,5-Difluoro-DL-phenylalanine 97%;3,5-Difluoro-DL-phenylalanine97%
• CAS NO: 32133-37-2
• Molecular Formula: C₉H₉F₂NO₂
• Molecular Weight: 201.17
• Product Categories: Peptide Synthesis;Phenylalanine Derivatives;Unnatural Amino Acid Derivatives
• Mol File: 32133-37-2.mol

Chemical Properties

• Melting Point: 269.5-273.5 °C(lit.)
• Boiling Point: 295.1 °C at 760 mmHg
• Flash Point: 132.3 °C
• Appearance: /
• Density: 1.379 g/cm³
• Vapor Pressure: 0.00065mmHg at 25°C
• Refractive Index: 1.534
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 2.13±0.20(Predicted)
• CAS DataBase Reference: DL-3,5-DIFLUOROPHENYLALANINE(CAS DataBase Reference)
• NIST Chemistry Reference: DL-3,5-DIFLUOROPHENYLALANINE(32133-37-2)
• EPA Substance Registry System: DL-3,5-DIFLUOROPHENYLALANINE(32133-37-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 36
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 32133-37-2(Hazardous Substances Data)

Usage

Uses

Used in Chemical Biology and Medicinal Chemistry:
DL-3,5-DIFLUOROPHENYLALANINE is used as a research tool for studying protein-ligand interactions and for the design of novel drugs. Its ability to alter protein function and stability upon incorporation makes it instrumental in understanding the structure-function relationships of proteins.
Used in Cancer Treatment Development:
In the pharmaceutical industry, DL-3,5-DIFLUOROPHENYLALANINE is used as a potential anticancer agent. Its investigation in this field is driven by its demonstrated promise in the development of new cancer therapies, offering a new avenue for treatment options.
Used in Antibiotic Development:
DL-3,5-DIFLUOROPHENYLALANINE is also utilized in the development of novel antibiotics. Its exploration in this area is based on its potential to contribute to the creation of new antimicrobial agents, addressing the growing need for effective treatments against drug-resistant infections.

InChI:InChI=1/C9H9F2NO2/c10-6-1-5(2-7(11)3-6)8(12)4-9(13)14/h1-3,8H,4,12H2,(H,13,14)

Upstream product

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Downstream Products

• 390387-79-8 3-(3,5-difluoro-phenyl)-2-oxo-propionic acid 
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• 1202927-88-5 2-amino-3-(3,5-difluorophenyl)propanamide 

Relevant articles and documents

Optimization and mechanistic studies of psammaplin A type antibacterial agents active against methicillin-resistant Staphylococcus aureus (MRSA)

As described in the preceding article, utilizing a novel combinatorial disulfide exchange strategy, a library of psammaplin A (1) analogues was constructed and screened for antibacterial activity leading to the identification of a collection of diverse lead compounds. These combinatorial leads were subsequently refined, through parallel synthesis, to afford a series of highly potent antibacterial agents (e.g. 17, 57, 58, 69, and 70), some possessing greater than 50-fold higher activities than the natural product. Evaluation of the selectivity and serum binding properties of some of the most promising compounds and preliminary studies directed at deciphering the mechanism of action of this novel class of antibacterial agents are also included.