- Hybrid functional mesostructured thin films with photo-oxidative properties in the visible range
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Hybrid mesostructured thin films functionalised with organic photosensitiser molecules demonstrated high efficiency for the decontamination of polluted atmosphere via singlet oxygen production.
- Saint-Cricq, Philippe,Pigot, Thierry,Nicole, Lionel,Sanchez, Clement,Lacombe, Sylvie
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- Visible Light-Initiated Bioorthogonal Photoclick Cycloaddition
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Here we report a visible light-triggered, catalyst free bioorthogonal reaction that proceeds via a distinct pathway from reported bioorthogonal reactions. The prototype of this bioorthogonal reaction was the photocycloaddition of 9,10-phenanthrenequinone with electron-rich alkenes to form fluorogenic [4+2] cycloadducts. The bioorthogonal photoclick cycloaddition was readily initiated using a conventional visible light source such as a hand-held LED lamp. The reaction proceeded rapidly under biocompatible conditions, without observable competition from side reactions such as nucleophilic additions by water or common nucleophilic species. The bioorthogonal functionality in this reaction did not cross react with various alkynes and electron-deficient alkenes such as monomethyl fumarate. We demonstrated orthogonal labeling of two proteins using this reaction together with a strain promoting azide-alkyne click reaction or the UV-triggered reaction of tetrazole with monomethyl fumarate. The application of this reaction in the temporal and spatial labeling of live cells was also demonstrated.
- Li, Jinbo,Kong, Hao,Huang, Lei,Zheng, Mengmeng,Yan, Zheng,Zhang, Yan,Cheng, Bo,Qin, Ke
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- Ultrafast Photoclick Reaction for Selective18F-Positron Emission Tomography Tracer Synthesis in Flow
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The development of very fast, clean, and selective methods for indirect labeling in PET tracer synthesis is an ongoing challenge. Here we present the development of an ultrafast photoclick method for the synthesis of short-lived18F-PET tracers
- Fu, Youxin,Helbert, Hugo,Simeth, Nadja A.,Crespi, Stefano,Spoelstra, Gerbren B.,van Dijl, Jan Maarten,van Oosten, Marleen,Nazario, Luiza Reali,van der Born, Dion,Luurtsema, Gert,Szymanski, Wiktor,Elsinga, Philip H.,Feringa, Ben L.
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- COMPOSITIONS AND METHODS OF MAKING EXPANDED HEMATOPOIETIC STEM CELLS USING PTEN INHIBITORS
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This invention is directed to, inter alia, compounds, methods, systems, and compositions for the maintenance, enhancement, and expansion of hematopoietic stem cells derived from sources of non-mobilized peripheral blood. Also provided herein are compounds of Formula I which are useful in maintaining, enhancing, and expanding of hematopoietic stem cells.
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- Cd45 inhibitors
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Substituted phenanthrene-9,10-diones in accord with structural diagram I, 1compositions thereof and methods for the use thereof, for the treatment of T cell mediated conditions such as autoimmune diseases and organ graft rejection. In compounds of the invention, R1 at each occurrence is independently selected from hydrogen, halogen, NH-tosyl, N-di-tosyl, NH2, NO2, NH—CO—R2, CO—NH—R2, Ar, (CH2)nCH(COOH)R3 COR3 and NHCOCH2CH(COOH)NHR4, where R2, R3 and R4 are a selected from a variety of substituted or unsubstituted alkyl and aryl groupstand oligopeptides.
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