321596-58-1Relevant articles and documents
Structure-Based Design of Selective Fat Mass and Obesity Associated Protein (FTO) Inhibitors
Aik, Wei Shen,Brown, Tom,Clunie-O'Connor, Caitlin,Demetriades, Marina,El-Sagheer, Afaf H.,Leissing, Thomas M.,Leung, Ivanhoe K. H.,Maheswaran, Pratheesh,McDonough, Michael A.,Ng, Yi Min,Salah, Eidarus,Schofield, Christopher J.,Shishodia, Shifali,Tam, Nok Yin,Tumber, Anthony,Zhang, Dong
, p. 16609 - 16625 (2021/11/24)
FTO catalyzes the Fe(II) and 2-oxoglutarate (2OG)-dependent modification of nucleic acids, including the demethylation of N6-methyladenosine (m6A) in mRNA. FTO is a proposed target for anti-cancer therapy. Using information from crystal structures of FTO
Fungicidal heterocyclic aromatic amides and their compositions, methods of use and preparation
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, (2015/09/28)
Heterocyclic aromatic amides having a hydroxy group adjacent to the amide functionality are useful as antifungal agents, particularly for plants.
NEW GPR119MODULATORS
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Page/Page column 63, (2010/01/07)
The application relates to compounds of Formula (Ia): and pharmaceutically acceptable salts, solvates, hydrates, geometrical isomers, tautomers, optical isomersor N-oxides thereof. The application also relates to pharmaceutical compositions comprising these compounds and to the use of these compounds for the prophylaxis and treatment of medical conditions relating to disorders of the G-protein- coupled receptor GPR119, such as diabetes, obesity and osteoporosis.
Fungicidal heterocyclic aromatic amides and their compositions, methods of use and preparation
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, (2008/06/13)
A compound having the following formula: wherein R3and M are defined herein, and processes therewith.