321704-19-2

Basic information

• Product Name: N-benzyl-4-ethylbenzenesulfonamide
• Synonyms: N-benzyl-4-ethylbenzenesulfonamide
• CAS NO: 321704-19-2
• Molecular Formula: C15H17NO2S
• Molecular Weight: 275.36598
• Mol File: 321704-19-2.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-benzyl-4-ethylbenzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-benzyl-4-ethylbenzenesulfonamide(321704-19-2)
• EPA Substance Registry System: N-benzyl-4-ethylbenzenesulfonamide(321704-19-2)

Safety Data

• Hazardous Substances Data: 321704-19-2(Hazardous Substances Data)

Upstream product

• 138-38-5 4-ethylbenzenesulfonamide 
• 108-88-3 toluene 

Relevant articles and documents

Method for catalytic synthesis of N-benzyl benzene sulfonamide compounds by boric acid/oxalic acid catalytic system under microwave radiation

The invention discloses a method for catalytic synthesis of N-benzyl benzene sulfonamide compounds by a boric acid/oxalic acid catalytic system under microwave radiation. The method includes: adoptingbenzyl alcohol and derivatives thereof and benzene sulfonamide derivatives as raw materials, adopting the boric acid/oxalic acid system as a catalyst, and adopting fluorobenzene as a solvent; performing reaction in a microwave reactor under certain temperature and power conditions, performing vacuum concentration after reaction for a period of time, and subjecting a product to column chromatographic purification to realize efficient catalytic preparation of the N-benzyl benzene sulfonamide compounds. Compared with the prior art, the method has advantages of evidently higher reaction speed than that of conventional heating, mild reaction conditions, simplicity in operation, high yield, safety, low cost and environmental friendliness.

Synthesis process of sulfonamide compounds in microwave system

The invention discloses a synthesis process of sulfonamide compounds in a microwave system. The synthesis process is realized by the following steps: by using CuCl as a catalyst and FeCl3 as an oxidant, carrying out carbon-hydrogen activating and carbon-nitrogen coupling reaction in a DMF (Dimethyl Formamide) by substituting sulfanilamide and methylbenzene through microwave heating and efficient catalysis for 10 to 60 minutes; extracting a product by using ethyl acetate; carrying out vacuum concentration; carrying out column chromatographic purification on a product to obtain the sulfonamide compounds. The synthesis process is a method for efficiently preparing the sulfonamide compounds, which is environment-friendly and is simple and convenient to operate. Compared with the prior art, the synthetic process disclosed by the invention has the advantages of remarkably-increased reaction speed compared with that under a conventional heating condition, mild reaction conditions, simple operation, high yield, safety, low cost and environmental protection.