- External oxidant-free cross-coupling of arylcopper and alkynylcopper reagents leading to arylalkyne
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External oxidant-free oxidative cross-coupling between arylcopper and alkynylcopper has been performed, which provides a new way for the formation of arylalkyne with high selectivity.
- Wang, Sheng,Min, Yaosen,Zhang, Xiaowei,Xi, Chanjuan
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p. 28308 - 28312
(2017/07/07)
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- High yielding electrophilic amination method for arylcopper reagents
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The facilitative effect of some P-, N-, S-, and O-donor ligands in the reaction of arylcoppers with acetone O-(mesitylenesulfonyl)oxime was examined to develop a synthesis method for functionalized primary aryl amines under mild reaction conditions. Our research showed that electrophilic amination of monoaryl coppers with ketoximes can be facilitated using appropriate ligand to supply significant increase in the yield. Also, we have seen that this ligand-facilitated method is applicable in terms of arylcopper and ketoxime type and allows synthesis of primary aryl amines in good to high yields easily at room temperature in very short reaction time.
- Da?kapan, Tahir,?i?ek, Semra
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supporting information
p. 899 - 906
(2017/04/27)
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- METHOD FOR PRODUCING BORATE SALT
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PROBLEM TO BE SOLVED: To provide a method for producing borate salt which makes it possible to obtain borate salt with different groups bound to boron atoms in high yield. SOLUTION: The present invention provides a method for producing borate salt (A) represented by general formula (1), including the steps for making a reaction occur between borate salt (B) represented by general formula (2) and organic metal compound (C) represented by general formula (3) or general formula (4). SELECTED DRAWING: None COPYRIGHT: (C)2016,JPOandINPIT
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Paragraph 0133
(2018/09/02)
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- Highly effective copper-mediated gem-difluoromethylenation of arylboronic acids
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A copper-mediated gem-difluoromethylenation of aryl, heteroaryl and vinyl boronic acids with bromodifluoromethylated oxazole or thiazole derivatives has been developed. This novel reaction showed an excellent functional group tolerance and wide substrate scope, providing facile access to practical application in drug discovery and development. the Partner Organisations 2014.
- Ma, Guobin,Wan, Wen,Hu, Qingyang,Jiang, Haizhen,Wang, Jing,Zhu, Shizheng,Hao, Jian
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supporting information
p. 7527 - 7530
(2014/07/07)
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- Reactivity of mixed organozinc and mixed organocopper reagents: 10 Comparison of the transferability of the same group in acylation of mixed and homo halozinc diorganocuprates with benzoyl chloride. A kinetic study
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A detailed kinetic study has been carried out for the acylation of iodozinc n-butyl (substituted phenyl) cuprates, n-Bu(FG-C6H4)CuZnI and iodozinc din-butylcuprate, n-Bu2CuZnI with benzoyl chloride in THF at 15-(-15)°C. Third order reaction was found which is first order in benzoyl chloride and second order in cuprate. We offered a reaction mechanism for the acylation of halozinc diorganocuprates depending on the kinetic data and activation parameters. Lower reaction rate of transferable group, n-Bu in mixed cuprate, n-Bu(PhCuZnI than that of homocuprate, n-Bu2CuZnI and Hammett correlation of the reaction rate of transferable group, n-Bu in n-Bu(FG-C6H4)CuZnI reagents with the substituent constants of residual group, FG-C6H4 with a positive reaction constant (relative reactivity of FG: 4-Br >3-MeO > H > 3-Me > 4-Me > 4-MeO) are in accordance with the proposed mechanism. These findings support our hypothesis that the reaction rate of transferable group, R T changes depending on the residual group, RR in mixed cuprates. RRRTCuM (M = Li, MgX, ZnX) and also provide a kinetic explanation for the commonly accepted hypothesis regarding the dependence of the RT group transfer ability on the strength of the R ReCu bond in mixed cuprates, RRRTCuLi.
- Pekel, ?zgen ?mür,Erdik, Ender
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p. 644 - 653
(2014/03/21)
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- Organocopper-mediated two-component SN2’-substitution cascade towards N-fused heterocycles
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Organocuprates efficiently undergo reaction with heterocyclic propargyl mesylates at low temperature to produce N-fused heterocycles. The copper reagent plays a “double duty” in this cascade transformation, which proceeds through an SN2’-substitution followed by a consequent cycloisomerization step.
- Chernyak,Gevorgyan
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p. 1516 - 1526
(2018/01/26)
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- Syntheses and structure of the solvent-separated calcium cuprate [(thf)3Ca(μ-Ph)3Ca(thf)3] +[Ph-Cu-Ph]-
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The transmetalation of phenylcopper yields the solvent-separated cuprate [(thf)3Ca(μ-Ph)3Ca(thf)3] +[Ph-Cu-Ph]-. This derivative extends the known classes of organic calcium compounds by an organometa
- Fischer, Reinald,Goerls, Helmar,Westerhausen, Matthias
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p. 3269 - 3271
(2008/10/09)
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- CONVENIENT SYNTHESIS OF (TRIPHENYL)GERMYL AND (TRIPHENYL)STANNYL SUBSTITUTED ALLENES
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Allenyl-germanes and -stannanes, Ph3MC(R)=C=CR'R" (M = Ge, Sn) can be obtained, generally in excellent yield, through alkylcopper(I)-induced 1,3-substitution of the propargylic chlorides Ph3MCCCR'R"Cl.In the tin series, however transmetallation is the
- Ruitenberg, K.,Westmijze, H.,Kleijn, H.,Vermeer, P.
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p. 227 - 234
(2007/10/02)
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