323196-70-9

Basic information

• Product Name: 2-CHLORO-7,8-DIMETHYL-3-QUINOLINECARBALDEHYDE
• Synonyms: 2-CHLORO-7,8-DIMETHYL-3-QUINOLINECARBALDEHYDE;AKOS BB-7552;2-CHLORO-7,8-DIMETHYLQUINOLINE-3-CARBOXALDEHYDE;OTAVA-BB 7020617818;2-chloro-7,8-dimethylquinoline-3-carbaldehyde
• CAS NO: 323196-70-9
• Molecular Formula: C₁₂H₁₀ClNO
• Molecular Weight: 219.67
• Mol File: 323196-70-9.mol

Chemical Properties

• Melting Point: 156 °C
• Boiling Point: 370.8°C at 760 mmHg
• Flash Point: 178.1°C
• Appearance: /
• Density: 1.27g/cm³
• Vapor Pressure: 1.08E-05mmHg at 25°C
• Refractive Index: 1.655
• PKA: -0.77±0.50(Predicted)
• CAS DataBase Reference: 2-CHLORO-7,8-DIMETHYL-3-QUINOLINECARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-7,8-DIMETHYL-3-QUINOLINECARBALDEHYDE(323196-70-9)
• EPA Substance Registry System: 2-CHLORO-7,8-DIMETHYL-3-QUINOLINECARBALDEHYDE(323196-70-9)

Safety Data

• Hazardous Substances Data: 323196-70-9(Hazardous Substances Data)

Usage

InChI:InChI=1/C12H10ClNO/c1-7-3-4-9-5-10(6-15)12(13)14-11(9)8(7)2/h3-6H,1-2H3

Upstream product

• 134-98-5 N-(2,3-dimethylphenyl)acetamide 
• 87-59-2 2,3-Dimethylaniline 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 1017429-47-8 (2-chloro-7,8-dimethylquinolin-3-yl)methanol 
• 1591873-31-2 C₃₅H₂₉ClN₂O₄ 
• 1591873-30-1 C₃₆H₃₁ClN₂O₄ 
• 1591873-40-3 C₃₂H₃₀N₂O₄ 
• 1591873-29-8 C₃₅H₃₀N₂O₄ 
• 1591873-28-7 C₃₅H₂₉ClN₂O₄ 
• 1591873-27-6 C₃₆H₃₂N₂O₅ 
• 1591873-50-5 C₃₆H₃₃N₃O₄ 
• 879045-29-1 1-(2-chloro-7,8-dimethyl-quinolin-3-ylmethyl)-1-(2-methoxy-ethyl)-3-p-tolyl-thiourea 

Relevant articles and documents

Montmorillonite-KSF-catalyzed synthesis of 4-heteroarylidene-N-arylhomophthalimides by Knoevenagel condensation

A simple, efficient and rapid method for clay-catalyzed Knoevenagel condensation of heterocyclic aldehydes with active methylene compound under reflux condition is reported. This protocol offers high yield, shorter time and simple work procedure. The protocol does not require column chromatography for purification, and the process is environmentally benign.

Synthesis and Herbicidal Activity of Triketone-Quinoline Hybrids as Novel 4-Hydroxyphenylpyruvate Dioxygenase Inhibitors

4-Hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27, HPPD) is one of the most important targets for herbicide discovery. In the search for new HPPD inhibitors with novel scaffolds, triketone-quinoline hybrids were designed and subsequently optimized on the basis of the structure-activity relationship (SAR) studies. Most of the synthesized compounds displayed potent inhibition of Arabidopsis thaliana HPPD (AtHPPD), and some of them exhibited broad-spectrum and promising herbicidal activity at the rate of 150 g ai/ha by postemergence application. Most promisingly, compound III-l, 3-hydroxy-2-(2-methoxy-7-(methylthio)quinoline-3-carbonyl)cyclohex-2-enone (Ki = 0.009 ～M, AtHPPD), had broader spectrum of weed control than mesotrione. Furthermore, compound III-l was much safer to maize at the rate of 150 g ai/ha than mesotrione, demonstrating its great potential as herbicide for weed control in maize fields. Therefore, triketone-quinoline hybrids may serve as new lead structures for novel herbicide discovery.

ZnO nanoparticles in the synthesis of AB ring core of camptothecin

For the first time, synthesis of AB ring core of camptothecin synthons such as (2-chloroquinolin-3-yl)methanols (Va-Vg) using zinc oxide nanoparticles is reported. The desired attractive products were obtained in high yields, short reaction time, using a simple work-up procedure with the purification of products by non-chromatographic methods.

Certain substituted quinolones, compositions, and uses thereof

Certain quinolone-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, methods of using compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions comprising compounds exhibiting ATP-utilizing enzyme inhibitory activity, are disclosed.