879045-29-1

Upstream product

• 323196-70-9 2-chloro-7,8-dimethyl-3-quinolinecarboxaldehyde 
• 622-59-3 1-isothiocyanato-4-methylbenzene 
• 644979-63-5 N-[(2-chloro-7,8-dimethylquinolin-3-yl)methyl]-2-methoxyethylamine 

Relevant academic research and scientific papers

2-chloro-3-quinolinecarboxaldehyde in the synthesis of condensed quinoline systems. 1. Synthesis of derivatives of 3,4-dihydro-2H-[1,3]thiazino[6,5-b]quinolines

A method for the synthesis of derivatives of previously unknown heterocyclic systems - 3,4-dihydro-2H-[1,3]thiazino[6,5-b]quinolines - has been developed based on 7,8-dimethyl-2-chloro-3-quinolinecarboxaldehyde via the consecutive steps of conversion into its Schiff's base with a primary amine, reduction to the corresponding aminomethyl derivative, conversion to the thiourea with isothiocyanates, and heterocyclization by intramolecular substitution of the chlorine atom.