- New quinoxalin-1,3,4-oxadiazole derivatives: Synthesis, characterization, in vitro biological evaluations, and molecular modeling studies
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A new series of quinoxalin-1,3,4-oxadiazole (10a–l) derivatives was synthesized and evaluated against some metabolic enzymes including human carbonic anhydrase (hCA) isoenzymes I and II (carbonic anhydrases I and II), cholinesterase (acetylcholinesterase
- Mirzazadeh, Roghieh,Asgari, Mohammad S.,Barzegari, Ebrahim,Pedrood, Keyvan,Mohammadi-Khanaposhtani, Maryam,Sherafati, Maedeh,Larijani, Bagher,Rastegar, Hossein,Rahmani, Hojjat,Mahdavi, Mohammad,Taslimi, Parham,Eda M.,Gul?in, ?lhami
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- HBTU-catalyzed simple and mild protocol for the synthesis of quinoxaline derivatives
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HBTU-catalyzed, simple, mild, and effective protocol for the synthesis of quinoxalines has been established. The reaction between 1,2-diamines, benzil, and catalytic amount of HBTU in ethanol resulted into quinoxalines. Various aliphatic, aromatic and het
- Bhushan, B. Popatkar,Gangadhar, A. Meshram
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- Triketone compound containing quinoxaline structure, and preparation method and application thereof
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The invention belongs to the technical field of medicine synthesis, and particularly relates to a triketone compound containing a quinoxaline structure, and a preparation method and an application thereof. The quinoxaline-containing triketone compound has a structure represented by general formula (I). The preparation method is mainly characterized in that a compound with a structure represented by formula (II) is contacted in the presence of an alkali and a solvent, and R1, R2, R3 and R4 in the formulas are respectively defined in the description. The quinoxaline-containing triketone compoundhas high herbicidal activity, and especially has an excellent effect of preventing and controlling broadleaf weeds and/or gramineous weeds, and the prevention and control effect is even better than that of some commercial herbicides sold in the market.
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Paragraph 0101-0103
(2020/03/13)
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- COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITY
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Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors de
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Paragraph 00480
(2018/08/26)
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- A NOVEL QUINOXALINE COMPOUND FOR ULTRAVIOLET ABSORBERS
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PURPOSE: A novel quinoxaline compound, isomer thereof, precursor drug thereof, or pharmaceutically acceptable salt thereof is provided to absorb UVA and UVB. CONSTITUTION: A quinoxaline compound is denoted by chemical formula 1. An UV absorber or pharmaceutical or cosmetic composition for antiaging contains the quinoxaline compound, isomer thereof, precursor drug thereof, or pharmaceutically acceptable salt, hydrate, or solvate thereof as an active ingredient.
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Paragraph 0087-0089; 0111-0113
(2017/10/21)
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- Catalytic application of recyclable silica-supported bismuth(III) chloride in the benzo[N,N]-heterocyclic condensation
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Silica-supported bismuth(III) chloride (BiCl3/SiO2) has been successfully employed in the condensation of 1,2-dicarbonyls with a variety of arene-1,2-diamines bearing either electron withdrawing or donating functional groups. The catalyzed reaction proceeded smoothly under ambient temperature in methanol to give the corresponding quinoxaline and pyrido[2,3-b]pyrazine compounds in good to excellent yields. The catalyst exhibited remarkable reusable activity and higher catalytic performance than homogeneous BiCl3. A plausible mechanism for the catalytic action of BiCl3/SiO2 has been introduced. Moreover, the crystal structure of the prepared unsymmetrical benzo[N,N]-heterocycles has been determined by single crystal X-ray diffraction.
- Aghapoor, Kioumars,Mohsenzadeh, Farshid,Shakeri, Atena,Darabi, Hossein Reza,Ghassemzadeh, Mitra,Neumüller, Bernhard
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p. 170 - 178
(2013/10/08)
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- A recyclable solid acid catalyst sulfated titania for easy synthesis of quinoxaline and dipyridophenazine derivatives under microwave irradiation
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TiO2SO42, prepared by solgel method has been used for the synthesis of quinoxaline and dipyridophenizine derivatives under microwave irradiation. High-resolution transmission electron microscope (HR-TEM) and atomic force m
- Krishnakumar, Balu,Swaminathan, Meenakshisundaram
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experimental part
p. 1261 - 1266
(2012/01/31)
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- Solvent free synthesis of quinoxalines, dipyridophenazines and chalcones under microwave irradiation with sulfated Degussa titania as a novel solid acid catalyst
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Sulfated TiO2-P25 (Degussa titania) has been prepared by sol-gel method using H2SO4 and characterized by FT-IR, XRD, FE-SEM, EDS, HR-TEM, XPS, DRS and BET surface area measurements. Sulfate loading by H2SO4 increases the Lewis acidity of Degussa tiatania. This catalyst gives an excellent yield with less reaction time and is an inexpensive and easily recyclable solid acid catalyst for the synthesis of quinaxalines, dipyridophenazines and chalcones under microwave irradiation.
- Krishnakumar,Swaminathan
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experimental part
p. 16 - 25
(2011/12/14)
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- An efficient protocol for the green synthesis of quinoxaline and dipyridophenazine derivatives at room temperature using sulfated titania
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Biologically active quinoxalines and dipyridophenazines were efficiently synthesized in excellent yield and less reaction time using inexpensive, easily recyclable sulfated titania (TiO2-SO42-). TiO2-SO42-
- Krishnakumar,Velmurugan,Jothivel,Swaminathan
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experimental part
p. 997 - 1002
(2010/10/03)
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- A recyclable and highly effective sulfated TiO2-P25 for the synthesis of quinoxaline and dipyridophenazine derivatives at room temperature
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Sulfated TiO2-P25 has been prepared using H2SO 4 and used for the synthesis of quinoxaline and dipyridophenazine derivatives. Sulfate loading by H2SO4 increases the Lewis acidity of TiO2-P2
- Krishnakumar,Swaminathan
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experimental part
p. 2572 - 2577
(2010/11/18)
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- Wells-Dawson type heteropolyacid catalyzed synthesis of quinoxaline derivatives at room temperature
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Wells-Dawson heteropolyacid (H6P2W18O 62 ? 24H2O) was used as an effective catalyst for the synthesis of biologically active quinoxaline derivatives from the condensation of o-phenylenediamines with 1,2-dicarbonyl compounds at room temperature in excellent yields. Springer-Verlag 2007.
- Heravi, Majid M.,Bakhtiari, Khadijeh,Bamoharram, Fatemeh F.,Tehrani, Maryam H.
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p. 465 - 467
(2008/02/02)
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- Structure-activity relationship (SAR) studies of quinoxalines as novel HCV NS5B RNA-dependent RNA polymerase inhibitors
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From chemical compound library screening using an HCV NS5B RNA-dependent RNA polymerase enzymatic assay, we identified a substituted quinoxaline hit with an IC50 of 5.5 μM. A series of substituted quinoxaline amide derivatives were synthesized
- Rong, Frank,Chow, Suetying,Yan, Shunqi,Larson, Gary,Hong, Zhi,Wu, Jim
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p. 1663 - 1666
(2008/02/13)
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- Synthesis and antiprotozoal activity of some new synthetic substituted quinoxalines
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A series of 29 new quinoxalines was synthesized and evaluated in vitro against several parasites (Leishmania donovani, Trypanosoma brucei brucei, and Trichomonas vaginalis). Several of them displayed interesting activities, and particularly four quinoxaline amides showed in vitro antileishmanial properties (IC50 less than 20 μM).
- Hui, Xu,Desrivot, Julie,Bories, Christian,Loiseau, Philippe M.,Franck, Xavier,Hocquemiller, Reynald,Figadere, Bruno
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p. 815 - 820
(2007/10/03)
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- Room-temperature free-radical-induced polymerization of 1,1′-(methylenedi-1,4-phenylene)bismaleimide via a novel diphenylquinoxaline-containing hyperbranched aromatic polyamide
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Two new diphenylquinoxaline-containing AB2 monomers, 2,3-bis(4-aminophenyl)quinoxaline-6-carboxylic acid, 5 and 2,3-bis[4-(4-aminophenoxy)phenyl]quinoxaline-6-carboxylic acid, 9 were prepared and polymerized via the Yamazaki reaction to form th
- Baek, Jong-Beom,Ferguson, John B.,Tan, Loon-Seng
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p. 4385 - 4396
(2007/10/03)
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- Bis-(ortho-aminophenol)-carboxylic acid AB2 monomer
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An AB2monomer of the formula: wherein Z is selected from the group consisting of —OH, —SH and —NH2HCl, is useful for the preparation of hyperbranched polybenzoxazoles.
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