- Investigation of the structure and opto-electronic properties of substituted 2,2′-bithiophenes as π-building blocks: A joint experimental and theoretical study
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We present the design and the synthesis of substituted 2,2′-bithiophene derivatives to be used as π-conjugated bridges in donor-π-acceptor molecules for dye sensitized solar cells. Using a combined theoretical and experimental approach, the photophysical and electrochemical properties of these linkers are also presented. Finally, we show that the photophysical properties (absorption/emission) of these molecules are preserved when doped in host matrices.
- Andicsová-Eckstein,Tokár,Kozma,Tokárová
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supporting information
p. 14871 - 14875
(2017/12/15)
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- Catalyst-controlled regiodivergent C-H borylation of multifunctionalized heteroarenes by using iridium complexes
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The regiodivergent C-H borylation of 2,5-disubstituted heteroarenes with bis(pinacolato)diboron was achieved by using iridium catalysts formed in situ from [Ir(OMe)(cod)]2/dtbpy (cod=1,5-cyclooctadiene, dtbpy: 4,4′-di-tert-butyl-2,2′-bipyridine) or [Ir(OMe)(cod)]2/2 AsPh3. When [Ir(OMe)(cod)]2/dtbpy was used as the catalyst, borylation at the 4-position proceeded selectively to afford 4-borylated products in high yields (dtbpy system A). The regioselectivity changed when the [Ir(OMe)(cod)]2/2 AsPh3 catalyst was used; 3-borylated products were obtained in high yields with high regioselectivity (AsPh3 system B). The regioselectivity of borylation was easily controlled by changing the ligands. This reaction was used in the syntheses of two different bioactive compound analogues by using the same starting material. Minor adjustments, major differences: The regiodivergent C-H borylation of 2,5-disubstituted heteroarenes with bis(pinacolato)diboron was achieved by using iridium catalysts formed in situ from [Ir(OMe)(cod)]2/dtbpy (cod=1,5-cyclooctadiene, dtbpy: 4,4'-di-tert-butyl-2,2'-bipyridine) or [Ir(OMe)(cod)]2/2 AsPh3 (see scheme).
- Sasaki, Ikuo,Taguchi, Jumpei,Hiraki, Shotaro,Ito, Hajime,Ishiyama, Tatsuo
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supporting information
p. 9236 - 9241
(2015/06/16)
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- Synthesis and fungicidal activity of tubulin polymerisation promoters. Part 2: Pyridazines
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Special tetrasubstituted pyridazines are potent fungicides by promoting the tubulin polymerisation, hereby disrupting the microtubule dynamics in the fungus. They are monocyclic analogs of similar substituted triazolopyrimidines and pyridopyrazines with the same mode of action. The fungicidal activity of these pyridazines was evaluated against the plant pathogens Botrytis cinerea (grey mould), Mycosphaerella graminicola (wheat leaf blotch) and Alternaria solani (potato and tomato early blight). Structure-activity relationship studies revealed the importance of a methyl and a chlorine substituent next to both ring nitrogen atoms and two aryl or heteroaryl groups in the other two pyridazine positions.
- Lamberth, Clemens,Trah, Stephan,Wendeborn, Sebastian,Dumeunier, Raphael,Courbot, Mikael,Godwin, Jeremy,Schneiter, Peter
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experimental part
p. 2803 - 2810
(2012/06/29)
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- Hair growth stimulator property of thienyl substituted pyrazole carboxamide derivatives as a cb1 receptor antagonist with in vivo antiobesity effect
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A few thienyl substituted pyrazole derivatives were synthesized to aid in the characterization of the cannabinoid receptor antagonist and also to serve as potentially useful antiobesity agent. Structural requirements for selective CB1 receptor antagonistic activity of 5-thienyl pyrazole derivatives included the structural similarity with potent, specific antagonist rimonabant 1. Compound 3 has been identified as a hair growth stimulator and an antiobesity agent in animal models.
- Srivastava, Brijesh Kumar,Soni, Rina,Patel, Jayendra Z.,Joharapurkar, Amit,Sadhwani, Nisha,Kshirsagar, Samadhan,Mishra, Bhupendra,Takale, Vijay,Gupta, Sunil,Pandya, Purvi,Kapadnis, Prashant,Solanki, Manish,Patel, Harilal,Mitra, Prasenjit,Jain, Mukul R.,Patel, Pankaj R.
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scheme or table
p. 2546 - 2550
(2010/01/16)
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- Ytterbium(III) trifluoromethanesulfonate catalysed Friedel-Crafts acylation of substituted thiophenes
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Ytterbium(III) trifluoromethanesulfonate [Yb(OTf)3] has been used to catalyse Friedel-Crafts acylation of substituted thiophenes in different solvents to produce several intermediates of pharmaceuticals and pesticides with good yields. The amount of catalysis was discussed and Yb(OTf)3 could be reused without loss of activity.
- Su, Weike,Jin, Can
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p. 694 - 695
(2007/10/03)
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