32427-82-0

Usage

Uses

Used in Pharmaceutical Industry:
1-(5-CHLOROTHIEN-2-YL)PROPAN-1-ONE is used as a synthetic intermediate for the development of pharmaceuticals, leveraging its unique structure to create novel drug candidates with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, 1-(5-CHLOROTHIEN-2-YL)PROPAN-1-ONE serves as a key intermediate in the synthesis of new agrochemicals, contributing to the development of effective pest control agents and other agricultural products.
Used as an Antibacterial Agent:
1-(5-CHLOROTHIEN-2-YL)PROPAN-1-ONE is studied for its potential as an antibacterial agent, indicating its use in combating bacterial infections and contributing to the discovery of new antimicrobial substances.
Used as an Antifungal Agent:
1-(5-CHLOROTHIEN-2-YL)PROPAN-1-ONE is also being investigated for its antifungal properties, suggesting its application in treating fungal infections and as a component in antifungal medications.
Used in Organic Electronic Materials:
1-(5-CHLOROTHIEN-2-YL)PROPAN-1-ONE has been explored for its potential use in the production of organic electronic materials, such as organic semiconductors and other components in electronic devices, due to its unique electronic properties.
Used as a Building Block in Synthesis:
Furthermore, 1-(5-CHLOROTHIEN-2-YL)PROPAN-1-ONE is utilized as a building block in the synthesis of various functionalized compounds, allowing for the creation of a wide range of chemical entities with diverse applications across different industries.

InChI:InChI=1/C7H7ClOS/c1-2-5(9)6-3-4-7(8)10-6/h3-4H,2H2,1H3

Upstream product

• 96-43-5 2-thienyl chloride 
• 79-03-8 propionyl chloride 
• 123-62-6 propionic acid anhydride 
• 24065-33-6 5-Chlorothiophene-2-carboxylic acid 
• 42518-98-9 5-chlorothiophene-2-carbonyl chloride 
• 2386-64-3 ethylmagnesium chloride 

Downstream Products

• 869891-50-9 5-(5-chloro-thiophen-2-yl)-1-(2',4'-dichloro-phenyl)-4-methyl-1H-pyrazol-3-carboxylic acid ethyl ester 
• 1374963-99-1 C₁₅H₁₀ClF₃O₃S 
• 1374964-00-7 C₁₅H₈ClF₃O₂S 
• 1002757-02-9 4-(5-chloro-thiophen-2-yl)-5-hydroxy-5-methyl-3-(2,4,6-trifluoro-phenyl)-5H-furan-2-one 
• 1021740-51-1 5-(5-chloro-thiophen-2-yl)-6-methyl-4-(2,4,6-trifluoro-phenyl)-2H-pyridazin-3-one 

Relevant academic research and scientific papers

Investigation of the structure and opto-electronic properties of substituted 2,2′-bithiophenes as π-building blocks: A joint experimental and theoretical study

We present the design and the synthesis of substituted 2,2′-bithiophene derivatives to be used as π-conjugated bridges in donor-π-acceptor molecules for dye sensitized solar cells. Using a combined theoretical and experimental approach, the photophysical and electrochemical properties of these linkers are also presented. Finally, we show that the photophysical properties (absorption/emission) of these molecules are preserved when doped in host matrices.

Catalyst-controlled regiodivergent C-H borylation of multifunctionalized heteroarenes by using iridium complexes

The regiodivergent C-H borylation of 2,5-disubstituted heteroarenes with bis(pinacolato)diboron was achieved by using iridium catalysts formed in situ from [Ir(OMe)(cod)]2/dtbpy (cod=1,5-cyclooctadiene, dtbpy: 4,4′-di-tert-butyl-2,2′-bipyridine) or [Ir(OMe)(cod)]2/2 AsPh3. When [Ir(OMe)(cod)]2/dtbpy was used as the catalyst, borylation at the 4-position proceeded selectively to afford 4-borylated products in high yields (dtbpy system A). The regioselectivity changed when the [Ir(OMe)(cod)]2/2 AsPh3 catalyst was used; 3-borylated products were obtained in high yields with high regioselectivity (AsPh3 system B). The regioselectivity of borylation was easily controlled by changing the ligands. This reaction was used in the syntheses of two different bioactive compound analogues by using the same starting material. Minor adjustments, major differences: The regiodivergent C-H borylation of 2,5-disubstituted heteroarenes with bis(pinacolato)diboron was achieved by using iridium catalysts formed in situ from [Ir(OMe)(cod)]2/dtbpy (cod=1,5-cyclooctadiene, dtbpy: 4,4'-di-tert-butyl-2,2'-bipyridine) or [Ir(OMe)(cod)]2/2 AsPh3 (see scheme).

Synthesis and fungicidal activity of tubulin polymerisation promoters. Part 2: Pyridazines

Special tetrasubstituted pyridazines are potent fungicides by promoting the tubulin polymerisation, hereby disrupting the microtubule dynamics in the fungus. They are monocyclic analogs of similar substituted triazolopyrimidines and pyridopyrazines with the same mode of action. The fungicidal activity of these pyridazines was evaluated against the plant pathogens Botrytis cinerea (grey mould), Mycosphaerella graminicola (wheat leaf blotch) and Alternaria solani (potato and tomato early blight). Structure-activity relationship studies revealed the importance of a methyl and a chlorine substituent next to both ring nitrogen atoms and two aryl or heteroaryl groups in the other two pyridazine positions.

Hair growth stimulator property of thienyl substituted pyrazole carboxamide derivatives as a cb1 receptor antagonist with in vivo antiobesity effect

A few thienyl substituted pyrazole derivatives were synthesized to aid in the characterization of the cannabinoid receptor antagonist and also to serve as potentially useful antiobesity agent. Structural requirements for selective CB1 receptor antagonistic activity of 5-thienyl pyrazole derivatives included the structural similarity with potent, specific antagonist rimonabant 1. Compound 3 has been identified as a hair growth stimulator and an antiobesity agent in animal models.

Ytterbium(III) trifluoromethanesulfonate catalysed Friedel-Crafts acylation of substituted thiophenes

Ytterbium(III) trifluoromethanesulfonate [Yb(OTf)3] has been used to catalyse Friedel-Crafts acylation of substituted thiophenes in different solvents to produce several intermediates of pharmaceuticals and pesticides with good yields. The amount of catalysis was discussed and Yb(OTf)3 could be reused without loss of activity.