32427-82-0

Basic information

• Product Name: 1-(5-CHLOROTHIEN-2-YL)PROPAN-1-ONE
• Synonyms: 1-(5-chloro-2-thienyl)propan-1-one(SALTDATA: FREE);1-(5-chloro-2-thienyl)propan-1-one;1-(5-CHLOROTHIEN-2-YL)PROPAN-1-ONE;Nsc80380
• CAS NO: 32427-82-0
• Molecular Formula: C₇H₇ClOS
• Molecular Weight: 174.65
• Mol File: 32427-82-0.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 270.9 °C at 760 mmHg
• Flash Point: 117.7 °C
• Appearance: /
• Density: 1.257 g/cm³
• Vapor Pressure: 0.00664mmHg at 25°C
• Refractive Index: 1.549
• CAS DataBase Reference: 1-(5-CHLOROTHIEN-2-YL)PROPAN-1-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(5-CHLOROTHIEN-2-YL)PROPAN-1-ONE(32427-82-0)
• EPA Substance Registry System: 1-(5-CHLOROTHIEN-2-YL)PROPAN-1-ONE(32427-82-0)

Safety Data

• Hazardous Substances Data: 32427-82-0(Hazardous Substances Data)

Usage

General Description

1-(5-CHLOROTHIEN-2-YL)PROPAN-1-ONE is a chemical compound with the molecular formula C8H9ClOS. It is a ketone with a thienyl ring that contains a chlorine atom. 1-(5-CHLOROTHIEN-2-YL)PROPAN-1-ONE is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It has been studied for its potential as an antibacterial and antifungal agent, as well as a component in the development of new drugs. Additionally, 1-(5-CHLOROTHIEN-2-YL)PROPAN-1-ONE has been investigated for its potential use in the production of organic electronic materials and as a building block in the synthesis of various functionalized compounds.

InChI:InChI=1/C7H7ClOS/c1-2-5(9)6-3-4-7(8)10-6/h3-4H,2H2,1H3

Upstream product

• 96-43-5 2-thienyl chloride 
• 79-03-8 propionyl chloride 
• 123-62-6 propionic acid anhydride 
• 24065-33-6 5-Chlorothiophene-2-carboxylic acid 
• 42518-98-9 5-chlorothiophene-2-carbonyl chloride 
• 2386-64-3 ethylmagnesium chloride 

Downstream Products

• 1374963-99-1 C₁₅H₁₀ClF₃O₃S 
• 1374964-00-7 C₁₅H₈ClF₃O₂S 
• 1002757-02-9 4-(5-chloro-thiophen-2-yl)-5-hydroxy-5-methyl-3-(2,4,6-trifluoro-phenyl)-5H-furan-2-one 
• 1021740-51-1 5-(5-chloro-thiophen-2-yl)-6-methyl-4-(2,4,6-trifluoro-phenyl)-2H-pyridazin-3-one 
• 869891-50-9 5-(5-chloro-thiophen-2-yl)-1-(2',4'-dichloro-phenyl)-4-methyl-1H-pyrazol-3-carboxylic acid ethyl ester 

Relevant articles and documents

Investigation of the structure and opto-electronic properties of substituted 2,2′-bithiophenes as π-building blocks: A joint experimental and theoretical study

We present the design and the synthesis of substituted 2,2′-bithiophene derivatives to be used as π-conjugated bridges in donor-π-acceptor molecules for dye sensitized solar cells. Using a combined theoretical and experimental approach, the photophysical and electrochemical properties of these linkers are also presented. Finally, we show that the photophysical properties (absorption/emission) of these molecules are preserved when doped in host matrices.

Synthesis and fungicidal activity of tubulin polymerisation promoters. Part 2: Pyridazines

Special tetrasubstituted pyridazines are potent fungicides by promoting the tubulin polymerisation, hereby disrupting the microtubule dynamics in the fungus. They are monocyclic analogs of similar substituted triazolopyrimidines and pyridopyrazines with the same mode of action. The fungicidal activity of these pyridazines was evaluated against the plant pathogens Botrytis cinerea (grey mould), Mycosphaerella graminicola (wheat leaf blotch) and Alternaria solani (potato and tomato early blight). Structure-activity relationship studies revealed the importance of a methyl and a chlorine substituent next to both ring nitrogen atoms and two aryl or heteroaryl groups in the other two pyridazine positions.

Ytterbium(III) trifluoromethanesulfonate catalysed Friedel-Crafts acylation of substituted thiophenes

Ytterbium(III) trifluoromethanesulfonate [Yb(OTf)3] has been used to catalyse Friedel-Crafts acylation of substituted thiophenes in different solvents to produce several intermediates of pharmaceuticals and pesticides with good yields. The amount of catalysis was discussed and Yb(OTf)3 could be reused without loss of activity.